基于Ansys的电化学加工辅助阴极设计

根据电化学加工极间间隙电势分布的拉普拉斯方程，提出了一种阴极设计算法－误差调整法。该算法的实现主要采用了Ansys有限元计算软件。计算结果表明：该法计算迭代次数较为适当，对于精度要求不高的电化学加工阴极设计，基于Ansys的辅助阴极设计有效可行。     

可重构电解加工机床研究

电解加工机床通常是根据用户具体需求单机生产，机床研制周期长、设计重复、成本高。为此，提出采用开放式控制系统、模块化思想开发可重构电解机床，并对机床的机械部分、控制系统及通信系统进行了研究。     

2-D Doppler shift-frequency intermittent sampling jamming against SAR

To generate the false targets in the desired area accurately, a novel two dimensional(2-D) intermittent sampling jamming algorithm against synthetic aperture radar(SAR) is presented. The intercepted radar signals are processed via 2-D intermittent sampling and Doppler shift-frequency and retransmitted to radar. Hence, the false target-lattice emerges in the specified area. The generation mechanism, position and distribution characteristics of false target-lattice are discussed. Meanwhile, the reason for the asymmetric amplitude of the target false-lattice and the modulation factor of energy compensation are presented. The correctness of theoretical analysis and validity of the proposed algorithm are verified through simulation experiments. Compared with conventional methods, the critical requirement of the jammer position can be reduced by the proposed method.     

微细电化学加工电源的设计与研究

加工电源的频率、波形等输出特性在很大程度上影响微细电化学加工的效果。本文提出的微细电化学加工电源系统包括硬件和软件两个模块，其中硬件模块包括计算机、接口电路、功率放大电路和信号检测电路；软件模模包括驱动程序和控制程序。该电源系统可产生多种波形，且能实现对加工过程的自适应控制，从而满足微细电化学加工工艺研究的需求。     

Development of new-concept desk top size machine tool

A desktop multiprocess machinery has been designed that has two concepts: miniaturizing of machine tool and multiprocessing with a same machine tool. The prototype of desktop multiprocess machinery is developed in this study. This is tabletop size machine tool that has five changeable machining heads. Outline of main body and machining head are presented.In order to know the basic accuracy of desktop multiprocess machinery, experimental evaluation is carried out. Machining head setting error, stiffness of multiprocess machinery and straightness of X, Y, Z stage is measured. To study the basic performance of desktop multiprocess machinery, a complex machining experiment is carried out with the developed machine tool. The complex machining consists of three steps: electrode machining by milling, hole shaping by EDM, and hole finishing by ECM. These steps are performed in sequence on the same machine tool. The complex machining is successfully carried out. In order to evaluate the desktop multiprocess machinery from environmental point of view, machining energy, volume of machining liquid, and installation space of desktop multiprocess machinery are measured. The measured values are compared with estimated values with conventional machine tools. The machining energy, the volume of machining liquid, and the installation space of desktop multiprocess machinery are smaller than those of conventional machine tool.     

基于混合最小二乘支持向量机网络模型的非线性系统辨识

针对基于输入输出数据的非线性系统辨识问题,提出一种新的混合最小二乘支持向量机(LS-SVMs)网络模型及相应的学习算法.该算法将系统的辨识问题动态自适应的划分为若干子问题,将支持向量机(SVM)用于各子模块辨识;通过分析模型的统计学特性,给出基于整体框架优化的系统参数辨识方法.针对系统中参数相关联的特性,采用期望条件最大化(ECM)算法对其进行条件辨识,同时结合正则化理论和最小二乘法,保证各专家模块的结构风险最小化辨识原则.试验结果表明,该方法兼具良好的辨识精度和泛化性能.     

Biological cardio-micro-pumps for microbioreactors and analytical micro-systems

Bio-hybrid microsystems actuated by living cells, as micro-bio-actuators and micro-bio-pumps have been developed recently. In these devices biological cells may be powered without external energy sources and the movement or the contraction of muscle cells trigger off the flow of fluid (i.e. culture medium or blood) through microchannels in micro-multi-bioreactor systems. Isolated and in vitro cultured cardiomyocytes (cardiac cells) are the most promising bio-material, which can be used to design a micro-bio-pump/actuator. These spontaneously contracting cells are autonomously powered with glucose as an energy source without any external power supply or stimulus, unlike conventional micro-actuators/micro-pumps. Cardio-micro-bio-pumps/actuators are using collective, synchronous contracting forces of cardiac cells or cardiac cell sheets to drive the flow of fluid. The feasibility of building such actuators was demonstrated in a few examples of bio-hybrid microsystems actuated by single or sheeted cardiomyocytes.     

Estimation of extreme percentiles in Birnbaum-Saunders distributions

The Birnbaum-Saunders distribution has recently received considerable attention in the statistical literature, including some applications in the environmental sciences. Several authors have generalized this distribution, but these generalizations are still inadequate for predicting extreme percentiles. In this paper, we consider a variation of the Birnbaum-Saunders distribution, which enables the prediction of extreme percentiles as well as the implementation of the EM algorithm for maximum likelihood estimation of the distribution parameters. This implementation has some advantages over the direct maximization of the likelihood function. Finally, we present results of a simulation study along with an application to a real environmental data set.     

电解加工中最小间隙检测方法

针对现有间隙检测方法存在精度低,且仅能测量平均间隙的缺点,提出一种测量最小间隙的简单方法———低电压湿对刀方法,介绍了湿对刀方法测最小加工间隙的原理,并进行了试验验证,试验结果表明:测量精度可达2μm。     

The EcpD Tip Adhesin of the Escherichia coli Common Pilus Mediates Binding of Enteropathogenic E. coli to Extracellular Matrix Proteins

The attachment of enteropathogenic Escherichia coli (EPEC) to intestinal epithelial cells is facilitated by several adhesins; however, the individual host-cell receptors for pili-mediated adherence have not been fully characterized. In this study, we evaluated the hypothesis that the E. coli common pilus (ECP) tip adhesin protein EcpD mediates attachment of EPEC to several extracellular matrix (ECM) glycoproteins (fibronectin, laminin, collagens I and IV, and mucin). We found that the ΔecpA mutant, which lacks production of the EcpA filament but retains EcpD on the surface, adhered to these glycoproteins below the wild-type levels, while the ΔecpD mutant, which does not display EcpA or EcpD, bound significantly less to these host glycoproteins. In agreement, a purified recombinant EcpD subunit bound significantly more than EcpA to laminin, fibronectin, collagens I and IV, and mucin in a dose-dependent manner. These are compelling data that strongly suggest that ECP-producing EPEC may bind to host ECM glycoproteins and mucins through the tip adhesin protein EcpD. This study highlights the versatility of EPEC to bind to different host proteins and suggests that the interaction of ECP with the host’s ECM glycoproteins may facilitate colonization of the intestinal mucosal epithelium.