全文获取类型
收费全文 | 9981篇 |
免费 | 507篇 |
国内免费 | 251篇 |
学科分类
医药卫生 | 10739篇 |
出版年
2024年 | 11篇 |
2023年 | 65篇 |
2022年 | 160篇 |
2021年 | 258篇 |
2020年 | 241篇 |
2019年 | 187篇 |
2018年 | 195篇 |
2017年 | 212篇 |
2016年 | 225篇 |
2015年 | 278篇 |
2014年 | 515篇 |
2013年 | 597篇 |
2012年 | 554篇 |
2011年 | 600篇 |
2010年 | 560篇 |
2009年 | 510篇 |
2008年 | 514篇 |
2007年 | 553篇 |
2006年 | 522篇 |
2005年 | 453篇 |
2004年 | 416篇 |
2003年 | 395篇 |
2002年 | 309篇 |
2001年 | 331篇 |
2000年 | 260篇 |
1999年 | 267篇 |
1998年 | 208篇 |
1997年 | 180篇 |
1996年 | 160篇 |
1995年 | 128篇 |
1994年 | 117篇 |
1993年 | 76篇 |
1992年 | 67篇 |
1991年 | 73篇 |
1990年 | 55篇 |
1989年 | 58篇 |
1988年 | 37篇 |
1987年 | 39篇 |
1986年 | 30篇 |
1985年 | 49篇 |
1984年 | 50篇 |
1983年 | 25篇 |
1982年 | 34篇 |
1981年 | 23篇 |
1980年 | 22篇 |
1979年 | 28篇 |
1978年 | 22篇 |
1977年 | 17篇 |
1976年 | 22篇 |
1975年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
AClinicalStudyofReversingLeftVentricularHypertrophyinHypertensivePatientsbyAdalatZhangFumin(张馥敏)XuDi(许迪)YongYonghong(雍永宏)Chen... 相似文献
3.
不同针刺深度对前列腺增生症大鼠重量指数的影响及形态学观察 总被引:7,自引:3,他引:4
目的与方法 采用深刺和浅刺对丙酸睾酮所致前列增生症(BPH)大鼠模型进行干预,研究其作用殊同。结果 针刺组前列腺,膀胱指数明显小于模型组;形态学观察,针刺组较模型组增生明显减轻,腺上皮呈单层柱状,腺体数目明显减少,间质充血,钙化明显减轻,结缔组织无增生,腺腔内分泌物减少。深刺组好于浅刺组。结论 深刺对实验性BPH大鼠的干预作用好于浅刺方法。 相似文献
4.
改良开放性手术治疗巨大良性前列腺增生症 总被引:2,自引:0,他引:2
目的探讨巨大良性前列腺增生症的开放性手术治疗方法及效果。方法回顾分析16例巨大良性前列腺增生症,年龄61~88岁,平均74岁。作耻骨上经膀胱前列腺切除术。结果手术均成功;手术时间35~65min,出血量100~200mL,术后前列腺重量为200~520g,平均215g;膀胱冲洗2~3d,拔导尿管5~7d;术后3d再出血1例,经DSA同侧髂内血管栓塞止血成功,排尿困难1例,短期尿失禁1例,其余患者术后均排尿通畅,控尿良好。结论开放性手术治疗巨大良性前列腺增生症,其梗阻解除彻底,是一种合理的治疗方法。恰当的手术方法是提高疗效及降低并发症的关键。 相似文献
5.
Background: Retinal pigment epithelium (RPE)lesions are predictive congenital phenotypic markersfor familial adenomatous polyposis (FAP). Thisprospective screening study aims at assessing theincidence and significance of these lesions in FAPpatients and their family members.Methods: Sixty-two members from three familiesincluding five patients with the diagnosis of FAP havebeen ophthalmologically surveyed. All RPE lesions weredocumented with fundus photography and fluoresceinangiography was performed in 13 subjects.Sigmoidoscopy and/or radiological examination wereperformed annually in 9 family members with typicalRPE lesions during 4 years to allow early diagnosis ofFAP.Results: Typical RPE lesions were present infive FAP patients and 15 family members.Telangiectatic dilatations in the retinal peripherywith small dot-like hemorrhages were detected in 6subjects from 3 families These lesions wereparticularly evident on fluorescein angiography.Annual colon analysis showed polyps in 3 out of 9subjects who were positive for RPE lesions.Conclusion: RPE lesions are valuable as aclinical marker in predicting FAP. The co-existingperipheral vascular alterations which have not beenreported before, are probably related to FAP. 相似文献
6.
1990年12月至1993年12月,我们对临床A-C期27例病人进行盆腔淋巴结活检术,检出12例D1期病人。临床A期有50%,B期有37%,C期有71%的病人发现盆腔淋巴结癌转移,其癌细胞的恶性程度也与淋巴结癌转移有关。近年,经腹腔镜盆腔淋巴结活检已成为诊断D1期前列腺癌的新方法。 相似文献
7.
nm23基因在前列腺癌中的表达与癌转移的关系 总被引:4,自引:0,他引:4
应用LSAB免疫组织化学染色方法,研究转移抑制基因nm23表达产物二磷酸核苷激酶(NDPK)在前列腺癌中的表达及其意义。结果表明,NDPK/nm23在前列腺癌中有较高的表达,阳性率为500%(20/40)。无前列腺癌转移者其阳性率为667%(12/18),有前列腺癌转移者其阳性率为364%(8/22),两者比较差异有显著性(P<005),并与前列腺癌分化程度和临床分期有显著相关。因此,nm23基因可能在前列腺癌形成及转移过程中起不同的调节作用,其表达程度与前列腺癌转移呈负相关,有可能成为评价前列腺癌病人预后的一项新指标。 相似文献
8.
S. Aziz L. A. Soine S. L. Lewis A. P. Kruse W. C. Levy K. M. Wehe D. P. Fishbien M. D. Allen 《Transplant international》1997,10(6):446-450
A review of factors contributing to early mortality after cardiac transplantation revealed that up to 25 % of deaths were
due to primary graft dysfunction unrelated to rejection or infection. In light of this finding, evaluation of a donor heart
with regard to its suitability for transplantation takes on added importance. In an effort to screen the suitability of donor
hearts in the region covered by the Northwest Organ Procurement Agency (USA), all donors are evaluated by two-dimensional
transthoracic echocardiography as part of the initial evaluation. A total of 110 donor echocardiograms were reviewed and an
attempt was made to correlate the 30-day outcome with the parameters measured. An unexpected finding was that the presence
of left ventricular hypertrophy in the donor heart was associated with an increase in the incidence of donor heart dysfunction
compared with donors with normal echocardiographic profiles (33 % vs 3 %, P = 0.007).
Received: 12 February 1996 Received after resision: 27 June 1997 Accepted: 14 July 1997 相似文献
9.
Bronwyn A. Kingwell Lisa Krause Stevo Julius 《Clinical and experimental pharmacology & physiology》1994,21(1):31-39
1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevation. 2. Five mongrel dogs were exposed to transient blood pressure elevation of between 20 and 30 mmHg, through hindlimb compression using a pneumatic pressure suit, for 7 h per day, 6 days per week for 6 weeks. Resting blood pressure was not altered by the 6 week hindlimb compression intervention. 3. Echocardiographically determined LV mass (mean ± s.e.m.) was 116.0 ± 7.4 g prior to hindlimb compression (baseline) and elevated to 125.4 ± 8.1 g (P= 0.003) after 6 weeks of compression. A reduction in the early (E) to late (A) transmitral diastolic flow ratio (E/A) from 1.80 ± 0.06 at baseline to 1.54 ± 0.09 (P = 0.037) after the 6 week intervention suggested that cardiac compliance was reduced. 4. The maximum gain of the MAP-HR reflex, studied using the ‘steady-state’ drug technique, when blood pressure was normal, showed a trend for reduction from 3.85 ± 0.43 beats/min per mmHg at baseline to 3.10 ± 0.45 beats/min per mmHg (P= 0.067) after 6 weeks of compression. This gain reduction became significant after β-adrenoceptor blockade with propranolol (3.13 ± 0.55 vs 2.32 ± 0.25 beats/min per mmHg; P= 0.039). Covariant analysis showed a significant inverse correlation between LV mass and maximum gain (r= 0.96; P<0.001) during the 6 week compression period. 5. The MAP-HR reflex changes in this model mimic those present in hypertension and implicate cardiac hypertrophy as one possible mediator. 相似文献
10.