基于重复测量数据的Poisson回归模型的偏大离差的Score检验

Poisson回归模型广泛应用于分析计数型数据 ,Dean&Lawless(1989)和Dean(1992 )讨论了非重复测量得到的计数型数据的偏大离差存在性的检验问题 .本文分别利用随机系数模型和对数非线性模型讨论了基于重复测量得到的计数型数据的偏大离差的检验问题 ,得到了检验的score统计量 .     

非线性纵向数据模型中自相关性和随机效应的存在性检验

刻画纵向数据协方差结构有三种可能因素 ,即序列相关 (特别是一阶自相关 )、随机效应和常规的随机误差 (Diggleetal,2 0 0 2 ) .本文研究非线性纵向数据模型的自相关性和随机效应存在性的单个和联合检验 ,得到了检验的score统计量 ,并利用血浆药物渗透数据 (Davidian&Gilinan ,1 995)说明检验方法的应用 .     

主成分分析应用方法的改进

首先对主成分分析应用中出现的一些误区,通过推导指出错误所在,并提出相应的改进方案.最后通过一个实例,说明新方案的合理性.     

随机权函数半参数回归模型的导方差统计分析

在回归分析中,观测值的方差齐性只是一个基本的假定,在参数、半参数和非参数回归模型中关于异方差检验和估计问题已有很多研究.本文在冉昊和朱忠义(2004)讨论的半参数回归模型的基础上,用随机参数方法,讨论随机权函数半参数回归模型中的异方差检验问题,得到了方差齐性检验Score统计量,同时,当半参数模型存在异方差时,本文还给出了估计方差的方法.     

在非线性回归模型中误差为AR(2)的相关性检验

本文讨论了在非线性回归模型中误差为AR(2)的相关性检验，得到了误差相关性检验的似然比检验统计量、Score检验统计量．对感兴趣参数和多余参数，利用Cox and Reid(1987)提出的正交化方法，给出了修正的似然比检验统计量和Score检验统计量．推广了胡跃清，韦博成(1994)讨论的在非线性回归模型中误差为AR(1)相关性检验的结果．     

An adjustable approach to fuzzy soft set based decision making

Molodtsov’s soft set theory was originally proposed as a general mathematical tool for dealing with uncertainty. Recently, decision making based on (fuzzy) soft sets has found paramount importance. This paper aims to give deeper insights into decision making based on fuzzy soft sets. We discuss the validity of the Roy-Maji method and show its true limitations. We point out that the choice value designed for the crisp case is no longer fit to solve decision making problems involving fuzzy soft sets. By means of level soft sets, we present an adjustable approach to fuzzy soft set based decision making and give some illustrative examples. Moreover, the weighted fuzzy soft set is introduced and its application to decision making is also investigated.     

区间直觉模糊数的新得分函数及其在多属性决策中的应用

通过对区间直觉模糊数的犹豫区间进行讨论,提出了区间直觉模糊数的新得分函数和精确函数,并讨论新的得分函数具有的性质,在此基础上给出了区间直觉模糊数的一种新的排序方法.进而,结合区间直觉模糊加权平均算子给出了属性值为区间直觉模糊数的多属性决策方法,并通过算例阐明该方法的可行性和有效性.     

含结构零2×2表中风险比齐性检验的样本量研究

本文研究了在临床和流行病学中出现的K个独立含结构零的2×2列联表.利用风险比推导出基于Wald型,基于对数变换型以及基于Score型的三个检验统计量,以检验层间齐性假设,获得了分别基于这三个检验统计量的控制功效的样本量公式和数值实验结果.模拟研究表明基于Score检验和基于对数变换检验的样本量公式比基于Wald检验的样本量公式更精确,更能有效保证预先给定的功效.推广了基于列联表问题的假设检验方法.     

Design,synthesis and evaluation of novel dehydroabietic acid-dithiocarbamate hybrids as potential multi-targeted compounds for tumor cytotoxicity

In the present study, novel representatives of the important group of biologically-active, dehydroabietic acid-bearing dithiocarbamate moiety, were synthesized and characterized by ¹H NMR, ¹³C NMR, HR-MS. The in vitro antiproliferative activity evaluation (MTT) indicated that these compounds exhibited potent inhibitory activities in various cancer cell lines (HepG-2, MCF-7, HeLa, T-24, MGC-803). Particularly, compound III-b possessed extraordinary cytotoxicity with low micromolar IC₅₀ values ranging from 4.07 to 38.84 µM against tested cancer cell lines, while displayed weak cytotoxicity on two normal cell lines (LO-2 and HEK 293 T). Subsequently, the potential mechanisms of representative compound III-b were elementarily investigated by Transwell experiment, which showed III-b can inhibit cancer cells migration. Annexin-V/PI dual staining showed that the compound can induce HepG-2 cells apoptosis in a dose-dependent manner. Meanwhile this apoptosis may be related to the upregulated protein expression of cleaved-caspase 3, cleaved-caspase 9, Bax and downregulated of Bcl-2 indicated by Western Blot. Later study further confirmed that ROS levels in HepG-2 cells increased significantly with the rise of concentrations. In addition, through the network pharmacology data analyzing, the core targets and signaling pathways of compound III-b for treatment of liver neoplasms were forecasted. Molecular docking model showed that compound III-b had high affinity with hub targets (CASP3, EGFR, HSP90AA1, MAPK1, ERBB2, MDM2), suggesting that compound III-b might target the hub protein to modulate signaling activity. Taken together, these data indicated that dehydroabietic acid structural modification following the “Molecular hybridization” principle is a feasible way to discover the potential multi-targeted antitumor compounds.     

Arc reversals of cycles in orientations of G vertex-multiplications

Ryser proved that any two tournaments with the same score sequence are $C_3$-equivalent while Beineke and Moon proved the $C_4$-equivalence for any two bipartite tournaments with the same score lists. In this paper, we extend these results to orientations of G vertex-multiplications. We focus on two main areas, namely orientations with the same score list and with score-list parity. Our main tools are extensions of the refinement technique, directed difference graph and a reduction lemma.