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AIM: To investigate the application of atomic force microscope (AFM) in clinic diagnosis. METHODS: Topographic images and some parameters of large range field and microstructures of erythrocytes in the blood of normal subjects, lung cancer and myelodisplastic syndrome (MDS) patients were examined by atomic force microscope. RESULTS: Many clear topographic images of many erythrocytes, single erythrocyte, and microstructure of erythrocyte membrane surface were obtained. Many erythrocytes in lung cancer patients were found to change into echinocytes. One erythrocyte had 10-20 protuberances, most of which, with a mean width of 589. 0 nm and a length of 646. 7 nm, were on the edge of cells. The protuberances on the center of echinocytes are lodged and embedded. The erythrocytes of MDS patients were biconcave in shape. Many apertures with different diameters of tens to hundreds nanometer appeared on the surface of cell membrane. CONCLUSIONS: AFM can be widely applied in clinic pathological inspection, including quantification of cells, obtainment and comparison of many parameters (such as diameter, thickness, volume, surface, surface area/volume ratio), observation of topograph of single cell, and observation and comparison of membrane surface microstructure of cells, and so on. 相似文献
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影响反力式滚筒制动试验台检测精度的因素 总被引:1,自引:0,他引:1
针对目前国内大部分汽车检测站使用的反力式滚筒制动试验台的检测数据存在较大差异的问题。详细分析了各种相关因素对汽车制动检测性能的影响以及正确使用反力式滚筒制动试验台的方法。 相似文献
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对于年金的时间价值的研究,往往假定利率在整个期间内是固定不变的.但事实上,由于受到多种因素的影响,利率通常具有不确定性.因此,本文采用可逆MA(1)模型对随机利息力进行建模,在此基础上,研究了期末付虹式年金和期末付平顶虹式年金的时间价值问题,给出了上述两种形式年金现值的期望和方差的递推公式.通过数值仿真分析了相关参数对期末付虹式年金现值的期望值的影响,其结论对投资者的投资决策提供了参考依据. 相似文献
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A 4-year-old Arab mare was diagnosed with disseminated cryptococcosis, including osteomyelitis of the proximal phalanx of the left hind limb, osteomyelitis with associated soft tissue granuloma of a rib and disseminated, large cryptococcal nodules in the lungs. The lesion in the dorsoproximal aspect of the proximal phalanx had a large area of cortical lysis with spiculated periosteal new bone and extensive soft tissue swelling. The affected rib had a pathological fracture. Cryptococcal osteomyelitis has not been previously reported in horses but should be considered as a differential diagnosis, particularly in endemic regions. 相似文献
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In this paper,four models are selected as the representatives and applied to nonlinear dynamic analysis program for space frames which is based on the beam-column elements using the finite element flexibility method and the fiber model.Park's test on combined axial and bending columns under cyclic loading are taken as the calibrations,comparisons to material and structural member level are drawn and the analytical results of various models are discussed. 相似文献
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The analysis of vibration response of structure with TMD is carried out under earthquake ,considering the ground-structure interaction. The varying rule of square difference of displacement of structure with the TMD on or off by changing the first inherent frequency is also presented .It has been proved by comparing and analyzing that a TMDstructure with optimum parameters can efficiently reduce the vibration of structure under strong wind and earthquake,when the main frequency of the ground motion is within the range of TMD vibration reducing frequency. 相似文献
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He Zonglu Duan Yurong 《保鲜与加工》1990,(5):98-105
The productive forces distribution model with entropy constraint is established. it satisfies both the demand with minimization of total cosls and the other demands with optimum distribution at a certain level. The model's regular optimal solution is a gravity molel.. 相似文献