全文获取类型
| 收费全文 | 23540篇 |
| 免费 | 719篇 |
| 国内免费 | 128篇 |
学科分类
| 医药卫生 | 24387篇 |
出版年
| 2024年 | 46篇 |
| 2023年 | 140篇 |
| 2022年 | 295篇 |
| 2021年 | 662篇 |
| 2020年 | 410篇 |
| 2019年 | 2641篇 |
| 2018年 | 2072篇 |
| 2017年 | 1351篇 |
| 2016年 | 308篇 |
| 2015年 | 318篇 |
| 2014年 | 1091篇 |
| 2013年 | 946篇 |
| 2012年 | 1159篇 |
| 2011年 | 911篇 |
| 2010年 | 710篇 |
| 2009年 | 555篇 |
| 2008年 | 440篇 |
| 2007年 | 416篇 |
| 2006年 | 371篇 |
| 2005年 | 305篇 |
| 2004年 | 196篇 |
| 2003年 | 198篇 |
| 2002年 | 152篇 |
| 2001年 | 145篇 |
| 2000年 | 109篇 |
| 1999年 | 69篇 |
| 1998年 | 59篇 |
| 1997年 | 42篇 |
| 1996年 | 23篇 |
| 1995年 | 51篇 |
| 1994年 | 39篇 |
| 1993年 | 10篇 |
| 1992年 | 12篇 |
| 1991年 | 10篇 |
| 1990年 | 6篇 |
| 1989年 | 7篇 |
| 1988年 | 12篇 |
| 1985年 | 611篇 |
| 1984年 | 1020篇 |
| 1983年 | 784篇 |
| 1982年 | 778篇 |
| 1981年 | 768篇 |
| 1980年 | 703篇 |
| 1979年 | 693篇 |
| 1978年 | 618篇 |
| 1977年 | 411篇 |
| 1976年 | 521篇 |
| 1975年 | 428篇 |
| 1974年 | 412篇 |
| 1973年 | 337篇 |
排序方式： 共有10000条查询结果，搜索用时 0 毫秒
1.
Ngai-Yin Chan Chi-Chung Choy Ho-Chuen Yuen Hoi-Fan Chow Ho-Fai Fong 《The Canadian journal of cardiology》2019,35(4):396-404
Background
Persistent iatrogenic atrial septal defect (iASD) is a common but poorly characterized complication after cryoballoon (CB) pulmonary vein isolation (PVI) procedures. We therefore investigate its prevalence, evolution, risk factors, and clinical outcomes in a prospective longitudinal study.Methods
A total of 108 patients (41 women, mean age 57 ± 11.3) underwent CB PVI for AF. Serial transesophageal echocardiography (TEE) was performed 9 months and then annually until 6 years after the procedure to study the characteristics of persistent iASD.Results
Persistent iASD occurred in 33 (30.6%) patients 9 months after CB PVI. Spontaneous closure of iASD was found in 6 (22.2%) and 3 (15.8%) patients 2 and 3 years after the procedures, respectively. No spontaneous closure was observed on 4, 5, and 6-year TEE follow-up. The projected long-term persistence rate of iASD after CB PVI was therefore 20% (30.6% × 0.778 × 0.842). Using multivariate logistic regression, a higher number of cryoapplications (≥ 2 minutes) was the only independent predictor of persistent iASD 9 months after CB PVI (odds ratio [OR] 1.207; 95% confidence interval [CI], 1.033-1.411, P = 0.018). Two (1.9%) patients with significantly larger iASD size than the others (long diameter 12.6 ± 0.8 vs 3.7 ± 1.5 mm, P < 0.001; short diameter 10.9 ± 0.2 vs 3 ± 1.1 mm, P < 0.001) required percutaneous closure because of exertional dyspnea and right ventricular enlargement. Over 129.7 patient-years follow-up, during which iASD persisted, there was no occurrence of neurologic events.Conclusions
Approximately one fifth of patients undergoing CB PVI will have permanently persistent iASD. Patients with defect sizes of greater than 10 mm may need percutaneous closure due to significant left-to-right shunting. 相似文献2.
Eitaro Ito Akihiro Takai Yoshinori Imai Hiromi Otani Yoshihiro Onishi Yosuke Yamamoto Kohei Ogawa Taiji Tohyama Shunichi Fukuhara Yasutsugu Takada 《Surgery》2019,165(2):353-359
Background
Controversy continues as to whether single-incision laparoscopic cholecystectomy, with the somewhat larger incision at the umbilicus, may lead to a worse postoperative quality of life and more pain compared with the more classic 4-port laparoscopic cholecystectomy. The aim of this study was to compare single-incision and 4-port laparoscopic cholecystectomy from the perspective of quality of life.Methods
This study was a multicenter, parallel-group, open-label, randomized clinical trial. A total of 120 patients who were scheduled to undergo elective cholecystectomy were randomly assigned 1:1 into the single-incision laparoscopic cholecystectomy or the 4-port laparoscopic cholecystectomy group and then assessed continuously for 2 weeks during the postoperative period. The primary outcome was quality of life, defined as the time to resume normal daily activities. Postoperative pain was also assessed. To explore the heterogeneity of treatment effects, we assessed the interactions of sex, age, and working status on recovery time.Results
A total of 58 patients in the single-incision group and 53 in the 4-port group (n?=?111, 47 male, mean age 57 years) were analyzed. The mean time to resume daily activities was 10.2 days and 8.8 days, respectively, for single-incision and 4-port laparoscopic cholecystectomy (95% confidence interval –0.4 to 3.2, P?=?.12). Similarly, the time to relief from postoperative pain did not differ significantly between the groups. Statistically insignificant but qualitative interactions were noted; in the subgroups of women, full-time workers, and patients younger than 60 years, recovery tended to be slower after single-incision laparoscopic cholecystectomy.Conclusion
Postoperative quality of life did not differ substantially between single-incision laparoscopic cholecystectomy and 4-port laparoscopic cholecystectomy. Patients younger than 60 years, women, and full-time workers tended to have a somewhat slower recovery after single-incision laparoscopic cholecystectomy. 相似文献3.
Traditional Chinese Medicine Compound Mianbu Mixfang Is Effective in Treating Immunological Infertility: a Female Mice 总被引：1，自引：0，他引：1
《生殖与避孕(英文版)》2002,(1)
Key words:anTraditional Chinese Medicine has been used to treat various diseases in Chinathousands of years before the introduction of Western Medicine and practices.Inrecent years it has also been used to treat the immunological infertility caused byAs A… 相似文献
4.
5.
良性前列腺增生中医证型与尿动力学参数相关性研究 总被引：1，自引：0，他引：1
目的:探讨良性前列腺增生(BPH)中医证型与尿动力学参数的相关性。方法:152例BPH患者,中医辨证分为肾阴不足、肾阳虚弱、瘀阻水道、脾气虚弱、肺热气郁、湿热下注、痰浊郁结七型,均进行尿动力学检查。结果:152例BPH患者中,肾阳虚弱型71例(46.71%),瘀阻水道型40例(26.31%),肾阴不足型14例(9.21%)。膀胱出口梗阻为III～VI度肾阳虚弱型有58例,瘀阻水道型有38例,其中严重梗阻(V～VI)26例。膀胱逼尿肌收缩功能极弱中(n=12),肾阳虚弱型4例,占33.33%(4/12),瘀阻水道型7例,占58.33%(7/12);膀胱逼尿肌收缩功能弱者中(n=48),肾阳虚弱型为27例,占56.25%(27/48),瘀阻水道型17例,占35.42%(17/48)。结论:BPH中医各辨证分型与膀胱出口梗阻和膀胱逼尿肌收缩力有一定的相关性,从而为中医证型的量化和客观化提供相应的证据。 相似文献
6.
浅议中医理论的科学美 总被引：4，自引：0，他引：4
科学美是美学形态分类中的一种 ,它从本质上反映事物运动的内在联系 ,属于美的深层形式。中医理论中存在简明、对称、新奇等科学美 相似文献
7.
8.
通过对口腔崩解片的特点及主要制备工艺的分析,结合当前中成药工业的现状及具体实际,认为口腔崩解片可以应用于中成药制剂的开发。 相似文献
9.
陈士铎《辨证录》辨证论治特点浅析 总被引：1，自引：0，他引：1
刘恩顺 《天津中医学院学报》2004,23(2):66-67
《辨证录》成书于清·康熙二十六年,是陈士铎现存著作中篇幅最长,于临床见证记述最全的一部书。全书在辨证论治上取古人意而不泥古人法,在辨证求因、审因论治上多有卓见。特点为:只言辨证不言辨脉;审查病机,同中求异,鉴别分明。辨证方法的选择,配伍应用有其自身特点:病种不同,侧重有别;辨证方法单独使用者少,配伍使用者多;以脏腑辨证为核心。 相似文献
10.
Donald M. Campbell Gerald I. Forbes 《International journal of environmental health research》1994,4(2):86-92
The prevention of the spread of disease by drinking water relies on a tripartate arrangement among the supplier, the regulator and their medical advisers. This paper describes the role of Public Health Medicine in Scotland in preventing a ‘significant risk to health’ from potable water. The legislative framework is highlighted. The rationale of water monitoring is examined and the role of Consultant in Public Health Medicine. The concept of Significant Medical Risk Values is introduced and their derivation, uses, and levels presented. 相似文献
