排序方式: 共有166条查询结果,搜索用时 15 毫秒
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Yingying Zhang Shuang Wang Lu Wang Xiaoyan Chang Yongxiao Fan Meiqing He Dawei Yan 《International journal of molecular sciences》2022,23(10)
Plasmodesmata (PD) are plant-specific channels connecting adjacent cells to mediate intercellular communication of molecules essential for plant development and defense. The typical PD are organized by the close apposition of the plasma membrane (PM), the desmotubule derived from the endoplasmic reticulum (ER), and spoke-like elements linking the two membranes. The plasmodesmal PM (PD-PM) is characterized by the formation of unique microdomains enriched with sphingolipids, sterols, and specific proteins, identified by lipidomics and proteomics. These components modulate PD to adapt to the dynamic changes of developmental processes and environmental stimuli. In this review, we focus on highlighting the functions of sphingolipid species in plasmodesmata, including membrane microdomain organization, architecture transformation, callose deposition and permeability control, and signaling regulation. We also briefly discuss the difference between sphingolipids and sterols, and we propose potential unresolved questions that are of help for further understanding the correspondence between plasmodesmal structure and function. 相似文献
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Jamie Afghani Claudia Traidl-Hoffmann Philippe Schmitt-Kopplin Matthias Reiger Constanze Mueller 《International journal of molecular sciences》2022,23(15)
Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin. 相似文献
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Carla Ferreri Anna Sansone Chryssostomos Chatgilialoglu Rosaria Ferreri Javier Amzaga Mercedes Caro Burgos Sara Arranz Itziar Tueros 《International journal of molecular sciences》2022,23(11)
Fatty acids have an important place in both biological and nutritional contexts and, from a clinical point of view, they have known consequences for diseases’ onset and development, including cancer. The use of fatty acid-based food and nutraceuticals to support cancer therapy is a multidisciplinary subject, involving molecular and clinical research. Knowledge regarding polyunsaturated fatty acids essentiality/oxidizability and the role of lipogenesis-desaturase pathways for cell growth, as well as oxidative reactivity in cancer cells, are discussed, since they can drive the choice of fatty acids using their multiple roles to support antitumoral drug activity. The central role of membrane fatty acid composition is highlighted for the application of membrane lipid therapy. As fatty acids are also known as biomarkers of cancer onset and progression, the personalization of the fatty acid-based therapy is also possible, taking into account other important factors such as formulation, bioavailability and the distribution of the supplementation. A holistic approach emerges combining nutra- and pharma-strategies in an appropriate manner, to develop further knowledge and applications in cancer therapy. 相似文献
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为深入了解婴儿时期人乳中复杂的脂质含量的动态变化,采用超高效液相色谱-三重四极杆串联飞行时间质谱及具有高采集命中率的顺序窗口采集所有理论质谱模式(sequential window acquisition of all theoretical massspectra,SWATH)对不同泌乳阶段人乳中的脂质进行鉴定及相对定量分析。结果显示,在3个泌乳阶段的人乳中共检测到229种脂质。根据“脂质代谢途径研究计划”中的分类,共检测到五大类物质:甘油酯类(glycerolipid,GL)主要包括24种甘油二酯和28种甘油三酯;甘油磷脂类(glycerophospholipid,GP)主要包括33种磷脂酰乙醇胺、21种磷脂酰胆碱、8种磷脂酰丝氨酸、13种磷脂酰甘油、10种磷脂酸和7种磷脂酰肌醇;鞘脂类(sphingolipid,SP)化合物共22种;甾醇脂类(sterol lipid,ST)化合物共10种;脂肪酸类及其衍生物(fatty acids,FAs)共4种。随着泌乳期的延长,GL、SP的相对含量逐渐增加,而GP、ST、FAs的相对含量逐渐下降。本研究实现了人乳中脂质的全面定性与相对定量分... 相似文献
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Albert Maim-Barcel Lucía Martín-Saiz Jos A. Fernndez Karim Prez-Romero Santiago Garfias-Arjona Mnica Lara-Almúnia Javier Pirola-Lopetegui Joan Bestard-Escalas Gwendolyn Barcel-Coblijn 《International journal of molecular sciences》2022,23(6)
Glioblastoma (GBM) represents one of the deadliest tumors owing to a lack of effective treatments. The adverse outcomes are worsened by high rates of treatment discontinuation, caused by the severe side effects of temozolomide (TMZ), the reference treatment. Therefore, understanding TMZ’s effects on GBM and healthy brain tissue could reveal new approaches to address chemotherapy side effects. In this context, we have previously demonstrated the membrane lipidome is highly cell type-specific and very sensitive to pathophysiological states. However, little remains known as to how membrane lipids participate in GBM onset and progression. Hence, we employed an ex vivo model to assess the impact of TMZ treatment on healthy and GBM lipidome, which was established through imaging mass spectrometry techniques. This approach revealed that bioactive lipid metabolic hubs (phosphatidylinositol and phosphatidylethanolamine plasmalogen species) were altered in healthy brain tissue treated with TMZ. To better understand these changes, we interrogated RNA expression and DNA methylation datasets of the Cancer Genome Atlas database. The results enabled GBM subtypes and patient survival to be linked with the expression of enzymes accounting for the observed lipidome, thus proving that exploring the lipid changes could reveal promising therapeutic approaches for GBM, and ways to ameliorate TMZ side effects. 相似文献
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Josep Rubert Kamila Hurkova Milena Stranska Jana Hajslova 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2018,35(4):605-613
Tiger nuts and tiger nut milk are well-known Valencian products, and step-by-step these tubers and the tuber-based beverage are becoming more and more relevant products in international markets. However, the increasing demand and success of Valencian tiger nuts did not allow protected designation of origin (PDO) tuber to supply the domestic and international markets. Therefore, the verification of the geographical origin is highly required. In this research, the main objective was to combine an advance analytical method and chemometrics tools in order to decipher the geographical origin of 45 tiger nut samples from (i) ‘Xufa de València’ PDO and (ii) African samples. The analytical method, based on solid-liquid extraction followed by ultra-high performance liquid chromatography coupled to high resolution tandem mass spectrometry (UHPLC-HRMS) metabolomics approach, highlighted sensitivity and wide linear dynamic range in order to simultaneously analyse polar and non-polar metabolites. After data processing, a pronounced sample clustering according to the geographical origin was clearly observed using unsupervised models, and supervised models revealed that tiger nuts lipidome was associated with the geographical origin. As a result, African samples highlighted an overexpression of phospholipids, such as phosphatidylethanolamine 34:1, and triacylgricerols crosslinked to environmental stress and alteration of membrane lipid compositions. 相似文献
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Pablo Hernndez‐Alonso Christopher Papandreou Mnica Bull Miguel Ruiz‐Canela Courtney Dennis Amy Deik Dong D. Wang Marta Guasch‐Ferr Edward Yu Estefanía Toledo Cristina Razquin Dolores Corella Ramon Estruch Emilio Ros Montserrat Fit Fernando Ars Miquel Fiol Lluís Serra‐Majem Liming Liang Clary B. Clish Miguel A Martínez‐Gonzlez Frank B Hu Jordi Salas‐Salvad 《Molecular nutrition & food research》2019,63(17)
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Gabriele Mocciaro Simona DAmore Benjamin Jenkins Richard Kay Antonio Murgia Luis Vicente Herrera-Marcos Stefanie Neun Alice P. Sowton Zoe Hall Susana Alejandra Palma-Duran Giuseppe Palasciano Frank Reimann Andrew Murray Patrizia Suppressa Carlo Sabb Antonio Moschetta Albert Koulman Julian L. Griffin Michele Vacca 《International journal of molecular sciences》2022,23(12)
The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors characterised by central obesity, atherogenic dyslipidaemia, and changes in the circulating lipidome; the underlying mechanisms that lead to this lipid remodelling have only been partially elucidated. This study used an integrated “omics” approach (untargeted whole serum lipidomics, targeted proteomics, and lipoprotein lipidomics) to study lipoprotein remodelling and HDL composition in subjects with central obesity diagnosed with MetS (vs. controls). Compared with healthy subjects, MetS patients showed higher free fatty acids, diglycerides, phosphatidylcholines, and triglycerides, particularly those enriched in products of de novo lipogenesis. On the other hand, the “lysophosphatidylcholines to phosphatidylcholines” and “cholesteryl ester to free cholesterol” ratios were reduced, pointing to a lower activity of lecithin cholesterol acyltransferase (LCAT) in MetS; LCAT activity (directly measured and predicted by lipidomic ratios) was positively correlated with high-density lipoprotein cholesterol (HDL-C) and negatively correlated with body mass index (BMI) and insulin resistance. Moreover, many phosphatidylcholines and sphingomyelins were significantly lower in the HDL of MetS patients and strongly correlated with BMI and clinical metabolic parameters. These results suggest that MetS is associated with an impairment of phospholipid metabolism in HDL, partially led by LCAT, and associated with obesity and underlying insulin resistance. This study proposes a candidate strategy to use integrated “omics” approaches to gain mechanistic insights into lipoprotein remodelling, thus deepening the knowledge regarding the molecular basis of the association between MetS and atherosclerosis. 相似文献
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