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1.
Charles A. White John F. Kennedy Anna Lombard Valeria Rossetti 《Polymer International》1985,17(4):327-329
The oligosaccharide component compositions of a series of non-reducing oligosaccharides extracted from the roots of Arnica montana L. has been determined by gel permeation chromatography (g.p.c.). The range of oligosaccharides present was found to extend beyond the octasaccharide previously reported. with 16% to 19% of the oligosaccharides having a degree of polymerisation of between 11 and 19 and almost 3% having a degree of polymerisation greater than 20. The chromatographic behaviour of this series of oligosaccharides is compared with that observed for series of D-gluco-oligosaccharides. 相似文献
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Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010 下载免费PDF全文
David J. Harvey 《Mass spectrometry reviews》2015,34(3):268-422
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Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody–Drug Conjugation Chemistry 下载免费PDF全文
Dr. Filip S. Ekholm Henna Pynnönen Anja Vilkman Virve Pitkänen Dr. Jari Helin Juhani Saarinen Tero Satomaa 《ChemMedChem》2016,11(22):2501-2505
Antibody–drug conjugates (ADCs) are promising alternatives to naked antibodies for selective drug‐delivery applications and treatment of diseases such as cancer. Construction of ADCs relies upon site‐selective, efficient and mild conjugation technologies. The choice of a chemical linker is especially important, as it affects the overall properties of the ADC. We envisioned that hydrophilic bifunctional chemical linkers based on carbohydrates would be a useful class of derivatization agents for the construction of linker–drug conjugates and ADCs. Herein we describe the synthesis of carbohydrate‐based derivatization agents, glycolinker–drug conjugates featuring the tubulin inhibitor monomethyl auristatin E and an ADC based on an anti‐EGFR antibody. In addition, an initial in vitro cytotoxicity evaluation of the individual components and the ADC is provided against EGFR‐positive cancer cells. 相似文献
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Synthesis and Evaluation of Glycoconjugates Comprising N‐Acyl‐Modified Thomsen–Friedenreich Antigens as Anticancer Vaccines 下载免费PDF全文
Shuang Sun Xiu‐Jing Zheng Chang‐Xin Huo Chengcheng Song Prof. Qin Li Prof. Xin‐Shan Ye 《ChemMedChem》2016,11(10):1090-1096
Thomsen–Friedenreich (TF) antigen is an important tumor‐associated carbohydrate antigen. Its low immunogenicity, however, limits its application in the development of anticancer vaccines. To solve this problem, several N‐acyl‐modified TF derivatives were synthesized and conjugated with carrier protein CRM197 (a mutated diphtheria toxoid cross‐reactive material). The immunological results in BALB/c mice demonstrated that these modified TF antigen conjugates could stimulate the production of higher titers of IgG antibodies that cross‐reacted with native TF antigen. These glycoconjugates showed strong lymphocyte proliferative response, suggesting that they can induce cellular immunity. Furthermore, the elicited antisera reacted strongly with TF‐positive tumor cells (4T1). In particular, the N‐monofluoroacetyl‐modified TF conjugate 4 ‐CRM197 showed the strongest complement‐dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine. 相似文献
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Gwénaëlle Hourdin Alain Germain Claude Moreau François Fajula 《Catalysis Letters》2000,69(3-4):241-244
Ti‐BEA and Ti‐FAU, obtained by post‐synthesis treatment, and TS‐1, obtained by direct hydrothermal synthesis, have been tested
as catalysts for the Ruff oxidative degradation of calcium d‐gluconate to d‐arabinose using diluted hydrogen peroxide as oxidant.
Only large‐pore zeolites Ti‐BEA and Ti‐FAU were found to be active. It was shown, in particular, that a very rapid leaching
of titanium occurred and that the titanium species present in the solution were responsible for the catalytic activity observed.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
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大鲵低聚糖肽性质初步研究 总被引:1,自引:0,他引:1
采用化学方法对大鲵低聚糖肽的氨基酸组成、糖组成及糖肽连接方式进行了初步研究。结果表明,大鲵低聚糖肽含蛋白量为80.01%、总糖含量为15.15%。其含有的氨基葡萄糖、葡萄糖醛酸、半乳糖醛酸及唾液酸分别为3.39%、0.65%、2.45%和0.60%。其氨基酸组成中,苏氨酸的含量最高,达13.1%,其次是脯氨酸、丙氨酸、亮氨酸、精氨酸、苯丙氨酸等。大鲵低聚糖肽的β-消旋反应和血凝集反应,表明大鲵低聚糖肽中糖肽键以O-连接的形式存在。 相似文献