基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

A note on the seafloor coupling characteristics of the new ONR ocean-bottom seismometer

A series of transient tests were conducted to determine the seafloor coupling characteristics of a new ocean-bottom seismometer (OBS) developed for the United States Office of Naval Research (ONR). The OBS comprises a large recording package and a separate sensor package that is deployed from the recording package. In addition to the coupling characteristics of both the sensor and the recording packages, the seismic energy radiated from the main recording package as a result of motion of the recording package was measured. The observed vertical coupling resonances of both the recording package and the sensor package are in good agreement with those predicted by a simple model of soil-structure interaction. The most important result of this study is that significant energy is radiated from the recording package in response to horizontal motions of the recording package. When the sensor package is 1 m from the recording package, the amplitude of the recorded signal is similar to that recorded in the recording package. In the field, this effect will result in distortion of seismic signals and increased background noise recorded by the sensor package if the recording package is disturbed by seafloor currents or biological activity. The amplitude of this signal attenuates by approximately a factor of two as sensor/recorder separation is increased from 1 to 6 m, suggesting that an improved response can be achieved by increasing the separation between the recording package and the sensors. This effect is much less severe for vertical disturbances of the recording package.     

地缘经济关系测度与分析的理论方法探讨--以云南省为例

文章首先简要分析了地缘经济学的发展进程和研究内容，提出以保护国家利益增强综合国力为主要研究目的的地缘经济理论在一定程度上可以指导不同级别区域经济合作策略的制定。然后在探究了地缘经济关系涵义的前提下，设计了地缘经济关系的测度体系，并用该方法对云南省地缘经济关系进行了数量测度和类型判别，进而对该省地缘经济关系进行了分析和评价，对经济发展提出了建议。     

b值在地震预测中的三类应用及其物理基础与须注意的问题

将b值在地震预测中的直接应用归为三类：1）根据b值的动态变化预测地震。2）根据G－R律求出各级地震平均复发周期或年均发生率，推测未来一定时段如50年或100年内发生各级地震的危险性。3）根据G－R直线在横轴的截距，预测强余震的震级。讨论了这三种用法的物理基础及现有工作中容易出现的问题。     

岩石断裂作用的复杂性和混沌动力学

断裂是一个复杂的动力学体系,受到岩石结构、反应、流体迁移、应力、岩石变形和力学等多种地质因素和过程的耦合控制。本文建立了断裂体系的反应-输运-力学耦合动力学模型并编制了模拟程序。以湖南水口山矿区为例,通过动力学模拟表明不同地层岩性的断裂渗透率大小和演化特征存在显著差异,断裂作用促使岩石渗透率的空间非均匀性增强,从而有利于流体的局部汇聚和矿体的形成。断裂中压力随时间呈现出非周期振荡变化,反映了断裂演化的混沌特征。     

人地非线性相关作用的探讨

从自组织系统思想出发，提出了人地关系的基本特性，通过逻辑斯蒂听数学变换，分析了人地非线性相关作用的混沌特性，进而讨论了人地关系的分形性质。基于混 过程与分形结构的因果关系，指出：地球表层系统中的人文分形景观乃是人地非线性关系的混沌作用所致。