排序方式: 共有97条查询结果,搜索用时 15 毫秒
1.
Afef Khanfir Faiez Lahiani Racem Bouzguenda Ines Ayedi Jamel Daoud Mounir Frikha 《Reports of Practical Oncology and Radiotherapy》2013,18(3):127-132
Background
The current retrospective study aims to identify some determinants of survival in metastatic breast cancer.Methods
The study concerned 332 patients with synchronous (SM) or metachronous (MM) metastatic breast cancer treated between January 2000 and December 2007. Statistical comparison between subgroups of patients concerning survival was carried out employing log-rank test for the invariable analysis and Cox model for the multivariable analysis. Factors included: age group (≤50 years vs. >50; ≤70 years vs. >70; ≤35 years vs. >35), menopausal status, presentation of metastatic disease (SM vs. MM), disease free interval (DFI) (≤24 months vs. >24 months; ≤60 months vs. >60 months), performance status at diagnosis of metastatic disease (PS) (0–1 vs. >1), hormone receptors (HR), number of metastatic sites (1 site vs. >1), nature of the metastatic site (visceral vs. non visceral), first line therapy, surgery of the primary tumor (SPT), locoregional radiotherapy (LRRT) and use or not of bisphosphonates.Results
Overall survival at 5 years was 12%. Positive prognostic factors in univariate analysis were: age ≤ 70 years, hormono-dependence of the tumor, good PS (PS 0–1), less than two metastatic sites, no visceral metastases, DFI ≥ 24 months, SPT or LRRT. In multivariate analysis, favorable independent prognostic factors included: good PS (PS 0–1), absence of visceral metastases (liver, lung, brain) and age ≤ 70 years.Conclusion
Many of the prognostic factors in metastatic breast cancer found in our study are known in the literature but some of them, like the application of locoregional treatment (radiotherapy or surgery) and the use of bisphosphonates, need to be further investigated in randomized clinical trials. 相似文献2.
3.
Ropers HH Hoeltzenbein M Kalscheuer V Yntema H Hamel B Fryns JP Chelly J Partington M Gecz J Moraine C 《Trends in genetics : TIG》2003,19(6):316-320
Analysis of linkage intervals from 125 unrelated families with nonsyndromic X-linked mental retardation (NS-XLMR) has revealed that the respective gene defects are conspicuously clustered in defined regions of the human X-chromosome, with approximately 30% of all mutations being located on the proximal Xp. In 83% of these families, underlying gene defects are not yet known. Our observations should speed up the search for mutations that are still missing and pave the way for the molecular diagnosis of this common disorder. 相似文献
4.
5.
To provide the required amount of storage and bandwidth, a video server typically comprises a large number of disks. As the
total number of disks increases, the influence of the striping algorithm that determines how video data are distributed across
the disks becomes decisive in terms of overall server cost and performance. Also introducing fault-tolerance against disk
failures becomes a must. In this paper, we first evaluate different striping algorithms in terms of throughput, buffer requirement,
and start-up latency for a non-fault-tolerant server. We then examine the impact of data striping on a fault-tolerant server
and show that the striping policy and the optimal technique to assure fault-tolerance are related: Depending on the technique
used to assure fault-tolerance (mirroring or parity), different striping techniques perform best.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
6.
Maila Giannandrea Maria Lidia Mignogna Salvatore Carrabino Matteo Vecellio Silvia Russo Lidia Larizza Hans-Hilger Ropers Vera Kalscheuer Cindy Skinner Jozef Gecz Hilde Van Esch Jamel Chelly Daniela Toniolo Patrizia D'Adamo 《American journal of human genetics》2010,86(2):185-195
Human Mental Retardation (MR) is a common and highly heterogeneous pediatric disorder affecting around 3% of the general population; at least 215 X-linked MR (XLMR) conditions have been described, and mutations have been identified in 83 different genes, encoding proteins with a variety of function, such as chromatin remodeling, synaptic function, and intracellular trafficking. The small GTPases of the RAB family, which play an essential role in intracellular vesicular trafficking, have been shown to be involved in MR. We report here the identification of mutations in the small GTPase RAB39B gene in two male patients. One mutation in family X (D-23) introduced a stop codon seven amino acids after the start codon (c.21C > A; p.Y7X). A second mutation, in the MRX72 family, altered the 5′ splice site (c.215+1G > A) and normal splicing. Neither instance produced a protein. Mutations segregate with the disease in the families, and in some family members intellectual disabilities were associated with autism spectrum disorder, epileptic seizures, and macrocephaly. We show that RAB39B, a novel RAB GTPase of unknown function, is a neuronal-specific protein that is localized to the Golgi compartment. Its downregulation leads to an alteration in the number and morphology of neurite growth cones and a significant reduction in presynaptic buttons, suggesting that RAB39B is required for synapse formation and maintenance. Our results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities. 相似文献
7.
Wüster W Allum CS Bjargardóttir IB Bailey KL Dawson KJ Guenioui J Lewis J McGurk J Moore AG Niskanen M Pollard CP 《Proceedings. Biological sciences / The Royal Society》2004,271(1556):2495-2499
Predator avoidance of noxious prey, aposematism and defensive mimicry are normally associated with bright, contrasting patterns and colours. However, noxious prey may be unable to evolve conspicuous coloration because of other selective constraints, such as the need to be inconspicuous to their own prey or to specialist predators. Many venomous snakes, particularly most vipers, display patterns that are apparently cryptic, but nevertheless highly characteristic, and appear to be mimicked by other, non-venomous snakes. However, predator avoidance of viper patterns has never been demonstrated experimentally. Here, the analysis of 813 avian attacks on 12,636 Plasticine snake models in the field shows that models bearing the characteristic zigzag band of the adder (Vipera berus) are attacked significantly less frequently than plain models. This suggests that predator avoidance of inconspicuously but characteristically patterned noxious prey is possible. Our findings emphasize the importance of mimicry in the ecological and morphological diversification of advanced snakes. 相似文献
8.
Jasper Lodder Timothé Dena?s Marie-No?le Chobert JingHong Wan Jamel El-Benna Jean-Michel Pawlotsky Sophie Lotersztajn Fatima Teixeira-Clerc 《Autophagy》2015,11(8):1280-1292
Autophagy is a lysosomal degradation pathway of cellular components that displays antiinflammatory properties in macrophages. Macrophages are critically involved in chronic liver injury by releasing mediators that promote hepatocyte apoptosis, contribute to inflammatory cell recruitment and activation of hepatic fibrogenic cells. Here, we investigated whether macrophage autophagy may protect against chronic liver injury. Experiments were performed in mice with mutations in the autophagy gene Atg5 in the myeloid lineage (Atg5fl/fl LysM-Cre mice, referred to as atg5−/−) and their wild-type (Atg5fl/fl, referred to as WT) littermates. Liver fibrosis was induced by repeated intraperitoneal injection of carbon tetrachloride. In vitro studies were performed in cultures or co-cultures of peritoneal macrophages with hepatic myofibroblasts. As compared to WT littermates, atg5−/− mice exposed to chronic carbon tetrachloride administration displayed higher hepatic levels of IL1A and IL1B and enhanced inflammatory cell recruitment associated with exacerbated liver injury. In addition, atg5−/− mice were more susceptible to liver fibrosis, as shown by enhanced matrix and fibrogenic cell accumulation. Macrophages from atg5−/− mice secreted higher levels of reactive oxygen species (ROS)-induced IL1A and IL1B. Moreover, hepatic myofibroblasts exposed to the conditioned medium of macrophages from atg5−/− mice showed increased profibrogenic gene expression; this effect was blunted when neutralizing IL1A and IL1B in the conditioned medium of atg5−/− macrophages. Finally, administration of recombinant IL1RN (interleukin 1 receptor antagonist) to carbon tetrachloride-exposed atg5−/− mice blunted liver injury and fibrosis, identifying IL1A/B as central mediators in the deleterious effects of macrophage autophagy invalidation. These results uncover macrophage autophagy as a novel antiinflammatory pathway regulating liver fibrosis. 相似文献
9.
Hafedh Makni Jamel Daoud Hanène Ben Salah Nedia Mahfoudh Olfa Haddar Héla Karray Tahya Boudawara Abdelmonême Ghorbel Abdelmajid Khabir Mounir Frikha 《Molecular biology reports》2010,37(5):2533-2539
In order to study the association of HLA-A, -B and/or DRB1, DQB1 and the nasopharyngeal carcinoma (NPC), 141 patients affected
with NPC were typed for the HLA class I by serology method of microlymphocytotoxicity. Among these patients 101 were genotyped
for HLA class II system by the PCR-SSP technique. HLA typing results were compared to those of 116 controls. We found that
the HLA-A31 and -A33 antigens were significantly more expressed in patients than in the controls (P = 0.016 and 0.010, respectively) and the HLA-A19 antigen, was significantly more frequent in patients when compared to the
controls (P = 0.007). The HLA-DRB1*03 and DRB1*13 alleles were significantly more frequent in patients as compared to the controls. The
DRB1*01 allele was expressed with a frequency of 20.69% in the controls whereas it was only detected in 3.96% of the NPC patients.
Furthermore, the DQB1*05 allele was expressed at a frequency which was significantly less important in affected patient (P = 0.03), whereas, the DQB1*02 allele was more frequent in patients (P = 0.643 × 10−4). Thus our study revealed a significant increase of HLA-A31, A33, A19, B16, B53 and DRB1*03, DRB1*13 and DQB1*02 alleles
in our patients. These markers could play a predisposing role in the development of NPC. In contrast, a decrease of HLA-B14,
-B35 and DRB1*01 and DQB1*05 alleles was found suggesting a likely protective effect. 相似文献
10.