Optimal Control of the Primary Drying Stage of Freeze Drying of Solutions in Vials Using Variational Calculus

The problem of operating freeze drying of pharmaceutical products in vials placed in trays of a freeze dryer to remove free water (in frozen state) at a minimum time was formulated as an optimal control problem. Two different types of freeze dryer designs were considered. In type I freeze dryer design, upper and lower plate temperatures were controlled together, while in type II freeze dryer design, upper and lower plate temperatures were controlled independently. The heat input to the material being dried and the drying chamber pressure were considered as control variables. Constraints were placed on the system state variables by the melting and scorch temperatures during primary drying stage. Necessary conditions of optimality for the primary drying stage of freeze drying process in vials are derived and presented. Furthermore, an approach for constructing the optimal control policies that would minimize the drying time for the primary drying stage was given. In order to analyze optimal control policy for the primary drying stage of the freeze-drying process in vials, a rigorous multi-dimensional unsteady state mathematical model was used. The theoretical approach presented in this work was applied in the freeze drying of skim milk. Significant reductions in the drying times of primary drying stage of freeze drying process in vials were obtained, as compared to the drying times obtained from conventional operational policies.     

Characterization of rheological properties of systems containing sugar substitutes and carrageenan

The effects of addition of κ-carrageenan to solutions containing 40% (w/w) sugar substitute on the rheological properties of these systems were investigated at 25 °C using a rotational viscometer at rotational speeds of 6, 12, 30, and 60 rev min⁻¹. The flow behaviour of the solutions was adequately described by the power law model with or without yield stress. The consistency index ( K ) and the flow behaviour index ( n ) were determined from shear stress vs. shear rate data. The flow parameters of the solutions depended on the carrageenan concentration. The apparent viscosities of the systems decreased with increasing shear rate, indicating pseudoplastic behaviour. The final carrageenan concentration was found to be an effective factor controlling the degree of sliminess of the model food systems studied.     

A capacitive threshold-logic gate

A dense and fast threshold-logic gate with a very high fan-in capacity is described. The gate performs sum-of-product and thresholding operations in an architecture comprising a poly-to-poly capacitor array and an inverter chain. The Boolean function performed by the gate is soft programmable. This is accomplished by adjusting the threshold with a dc voltage. Essentially, the operation is dynamic and thus, requires periodic reset. However, the gate can evaluate multiple input vectors in between two successive reset phases because evaluation is nondestructive. Asynchronous operation is, therefore, possible. The paper presents an electrical analysis of the gate, identifies its limitations, and describes a test chip containing four different gates of fan-in 30, 62, 127, and 255. Experimental results confirming proper functionality in all these gates are given, and applications in arithmetic and logic function blocks are described     

Microarchitectures for Managing Chip Revenues under Process Variations

As transistor feature sizes continue to shrink intothe sub-90nm range and beyond, the effects of process variationson critical path delay and chip yields have amplified. A commonconcept to remedy the effects of variation is speed-binning, bywhich chips from a single batch are rated by a discrete range offrequencies and sold at different prices. In this paper, we discussstrategies to modify the number of chips in different bins andhence enhance the profits obtained from them. Particularly, wepropose a scheme that introduces a small Substitute Cacheassociated with each cache way to replicate the data elementsthat will be stored in the high latency lines. Assuming a fixedpricing model, this method increases the revenue by as much as13.8% without any impact on the performance of the chips.     

Robust pose invariant face recognition using coupled latent space discriminant analysis

We propose a novel pose-invariant face recognition approach which we call Discriminant Multiple Coupled Latent Subspace framework. It finds the sets of projection directions for different poses such that the projected images of the same subject in different poses are maximally correlated in the latent space. Discriminant analysis with artificially simulated pose errors in the latent space makes it robust to small pose errors caused due to a subject’s incorrect pose estimation. We do a comparative analysis of three popular latent space learning approaches: Partial Least Squares (PLSs), Bilinear Model (BLM) and Canonical Correlational Analysis (CCA) in the proposed coupled latent subspace framework. We experimentally demonstrate that using more than two poses simultaneously with CCA results in better performance. We report state-of-the-art results for pose-invariant face recognition on CMU PIE and FERET and comparable results on MultiPIE when using only four fiducial points for alignment and intensity features.     

Design of a Commercial Hybrid VTOL UAV System

For the last four decades Unmanned Air Vehicles (UAVs) have been extensively used for military operations that include tracking, surveillance, active engagement with weapons and airborne data acquisition. UAVs are also in demand commercially due to their advantages in comparison to manned vehicles. These advantages include lower manufacturing and operating costs, flexibility in configuration depending on customer request and not risking the pilot on demanding missions. Even though civilian UAVs currently constitute 3 % of the UAV market, it is estimated that their numbers will reach up to 10 % of the UAV market within the next 5 years. Most of the civilian UAV applications require UAVs that are capable of doing a wide range of different and complementary operations within a composite mission. These operations include taking off and landing from limited runway space, while traversing the operation region in considerable cruise speed for mobile tracking applications. This is in addition to being able traverse in low cruise speeds or being able to hover for stationary measurement and tracking. All of these complementary and but different operational capabilities point to a hybrid unmanned vehicle concept, namely the Vertical Take-Off and Landing (VTOL) UAVs. In addition, the desired UAV system needs to be cost-efficient while providing easy payload conversion for different civilian applications. In this paper, we review the preliminary design process of such a capable civilian UAV system, namely the TURAC VTOL UAV. TURAC UAV is aimed to have both vertical take-off and landing and Conventional Take-off and Landing (CTOL) capability. TURAC interchangeable payload pod and detachable wing (with potential different size variants) provides capability to perform different mission types, including long endurance and high cruise speed operations. In addition, the TURAC concept is to have two different variants. The TURAC A variant is an eco-friendly and low-noise fully electrical platform which includes 2 tilt electric motors in the front, and a fixed electric motor and ducted fan in the rear, where as the TURAC B variant is envisioned to use high energy density fuel cells for extended hovering time. In this paper, we provide the TURAC UAV’s iterative design and trade-off studies which also include detailed aerodynamic and structural configuration analysis. For the aerodynamic analysis, an in-house software including graphical user interface has been developed to calculate the aerodynamic forces and moments by using the Vortex Lattice Method (VLM). Computational Fluid Dynamics (CFD) studies are performed to determine the aerodynamic effects for various configurations For structural analysis, a Finite Element Model (FEM) of the TURAC has been prepared and its modal analysis is carried out. Maximum displacements and maximal principal stresses are calculated and used for streamlining a weight efficient fuselage design. Prototypes have been built to show success of the design at both hover and forward flight regime. In this paper, we also provide the flight management and autopilot architecture of the TURAC. The testing of the controller performance has been initiated with the prototype of TURAC. Current work focuses on the building of the full fight test prototype of the TURAC UAV and aerodynamic modeling of the transition flight.     

The C-loss function for pattern classification

This paper presents a new loss function for neural network classification, inspired by the recently proposed similarity measure called Correntropy. We show that this function essentially behaves like the conventional square loss for samples that are well within the decision boundary and have small errors, and L₀ or counting norm for samples that are outliers or are difficult to classify. Depending on the value of the kernel size parameter, the proposed loss function moves smoothly from convex to non-convex and becomes a close approximation to the misclassification loss (ideal 0–1 loss). We show that the discriminant function obtained by optimizing the proposed loss function in the neighborhood of the ideal 0–1 loss function to train a neural network is immune to overfitting, more robust to outliers, and has consistent and better generalization performance as compared to other commonly used loss functions, even after prolonged training. The results also show that it is a close competitor to the SVM. Since the proposed method is compatible with simple gradient based online learning, it is a practical way of improving the performance of neural network classifiers.     

A method for automatic classification of gender based on text- independent handwriting

Handwriting recognition is used for the prediction of various demographic traits such as age, gender, nationality, etc. Out of all the applications gender prediction is mainly admired topic among researchers. The relation between gender and handwriting can be seen from the physical appearance of the handwriting. This research work predicts gender from handwriting using the landmarks of differences between the two genders. We use the shape or visual appearance of the handwriting for extracting features of the handwriting such as slanteness (direction), area (no of pixels occupied by text), perimeter (length of edges), etc. Classification is carried out using the Support Vector Machine (SVM) as a classifier which transforms the nonlinear problem into linear using its kernel trick, logistic regression, KNN and at the end to enhance the classification rates we use Majority Voting. The experimental results obtained on a dataset of 282 writers with 2 samples per writer shows that the proposed method attains appealing performance on writer detection and text-independent environment.

     

Estimation of impact forces during multi-point collisions involving small deformations

Multibody System Dynamics - Collision between hard objects causes abrupt changes in the velocities of the system, which are characterized by very large contact forces over very small time...     

Ferroelectric liquid crystals: Excellent tool for modern displays and photonics

The ferroelectric liquid crystals, because of their fast electro‐optical response, are one of the most important classes of liquid crystals. Here, in this review, we have summarized the different electro‐optical modes for ferroelectric liquid crystals. Clark–Lagerwall effect (surface stabilized ferroelectric liquid crystal), deformed helix ferroelectric (DHF) effect, electrically suppressed helix (ESH) mode, DHF orientational Kerr effect, and ESH diffraction modes have been discussed. All of the crucial features, that is, optics, electro‐optics, dynamics, and their dependence on material parameters, operational regime, and applications, have been reviewed.