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1.
Jill P Ginsberg Avital Cnaan Huaqing Zhao Bernard J Clark Stephen M Paridon Alvin J Chin Jack Rychik Alexa N Hogarty Gerald Barber Monika Rutkowski Thomas R Kimball Cynthia DeLaat Laurel J Steinherz Jeffrey H Silber 《Journal of clinical oncology》2004,22(15):3149-3155
PURPOSE: As the number of pediatric cancer survivors increases, so does the number of survivors previously exposed to anthracyclines as part of their cancer therapy. Because screening is costly, some have suggested that health-related quality of life (HRQL) measures might be useful in focusing screening tests on those patients with cases most likely to display positive findings. This study reports on the predictive ability of HRQL measures to detect patients with abnormalities on serial cardiac testing. METHODS: Using 127 patients from the ACE-Inhibitor after Anthracycline (AAA) Trial, this study compared serial measures of the Short Form-36 (SF-36; for ages > 13 years) and Child Health Questionnaire-Child Form 87 (CHQ-CF87; for ages < or = 13 years) to serial cardiac performance tests including echocardiographic shortening fraction, left ventricular end systolic wall stress (LVESWS), LVESWS-index, and maximal cardiac index (MCI; a measure of cardiac output at peak exercise). RESULTS: Generally, there was no clinically or statistically significant correlation between any HRQL measure and any cardiac function measure except between MCI and vitality and physical functioning. For each of these measures, the correlation between MCI was statistically significant (P < .006), but each HRQL subscale could explain no more than 7% of the variation in MCI. HRQL measures were not predictive of any other cardiac function measure. CONCLUSION: HRQL measures should not be used in isolation as a screen for cardiac function abnormalities in patients exposed to anthracylines who already have a mild degree of ventricular dysfunction. Patient history appears to be no substitute for cardiac testing in this cohort. 相似文献
2.
Edelstein A Yavetz H Kleiman SE Botchan A Hauser R Paz G Yogev L 《Fertility and sterility》2008,90(1):205-208
A similarity was found between the percentage of thawed, DNA-damaged spermatozoa in cancer patients and that in candidates to become sperm bank donors who had low sperm cryofreezability. Both groups were significantly different from the sperm bank donor group. It is suggested that the higher rate of DNA fragmentation in sperm from cancer patients compared with sperm bank donors is apparently a result of selecting donors by the level of sperm cryofreezability (i.e., high), rather than a direct effect of an existing malignancy. 相似文献
3.
Eliad Karin Shmuel Avital Iris Dotan Yehuda Skornick Ron Greenberg 《Colorectal disease》2012,14(1):111-114
Aim: The outcome of Doppler‐guided haemorrhoidal artery ligation (DGHAL) was assessed in patients with Crohn’s disease (CD) suffering from grade III haemorrhoids. Method: A retrospective study was carried out of patients with CD and symptomatic Grade III haemorrhoids treated by DGHAL. Perioperative and follow‐up data were retrieved from our database of patients undergoing DGHAL. Results: The study included seven men and six women. The mean age was 34 years old. All had CD without anorectal involvement. The median duration of haemorrhoidal symptoms was 6.3 years. There was no mortality, new incontinence, faecal impaction, urinary retention, abscess formation or persistent pain following the procedure. Mean pain score based on a visual analogue scale (VAS) decreased from 2.4 at 24 h postoperatively to 1.6 on the seventh postoperative day. All patients had completely recovered by the third postoperative day. At 18 months, three (77%) of the patients were asymptomatic and three had recurrent symptoms. Conclusion: Doppler‐guided haemorrhoidal artery ligation is safe and effective in treating Grade III haemorrhoids in patients with CD without rectal involvement. 相似文献
4.
Exhaled nitric oxide is age-dependent in asthma 总被引:1,自引:0,他引:1
Avital A Uwyyed K Berkman N Bar-Yishay E Godfrey S Springer C 《Pediatric pulmonology》2003,36(5):433-438
We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age-dependent. Eighty-seven asthmatic patients aged 2-41 years were studied. Hyperreactivity to adenosine 5'-monophosphate (AMP) was used to confirm asthma (= 200 mg/ml). In the younger group of children (2-5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6-41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P < 0.0001). The equation of correlation between the two methods was eNOTBm = 0.78eNOSVCm - 0.51. Within asthmatic patients, we found a significant increase in eNO with age (P < 0.0001), while there was no significant difference in AMP reactivity (P = 0.35). We conclude that eNO in asthmatic patients is age-dependent, with lower values in young children. 相似文献
5.
Purpose
The aim of the study was to evaluate the long-term results, early and late complication rates and overall satisfaction of patients with grade III hemorrhoids treated by stapled hemorrhoidopexy (SH) or doppler-guided hemorrhoidal artery ligation (DGHAL).Methods
Operative and follow-up patient data were prospectively collected for patients undergoing either SH or DGHAL by a single surgeon during a 2-year period. A retrospective comparison between patient outcomes after operations by one of the two methods was made based on these data. Clinical data on postoperative pain, analgesic requirements, time to first bowel movement and functional recovery were collected at five postoperative follow-up visits (1 and 6 weeks, 6, 12, and 18 months). Data on patient satisfaction, recurrence of hemorrhoidal symptoms and further treatment were obtained from a standardized questionnaire completed during the last visit 18 months postoperatively.Results
A total of 63 patients underwent SH (average age 52?±?3.2 years) and 51 patients underwent DGHAL (average age 50?±?7.3 years). The DGHAL patients experienced less postoperative pain as scored by pain during bowel movement (2.1?±?1.4 vs. 5.5?±?1.9 for SH), and required less postoperative analgesics. Hospital stay, time to first bowel movement and complete functional recovery were also significantly shorter for the DGHAL patients. A total of 9 DGHAL patients (18%) suffered from persistent bleeding or prolapse and required additional treatment compared with 2 (3%) patients in the SH group. The SH patients reported greater satisfaction compared with DGHAL patients at 1 year postoperatively.Conclusions
Both SH and DGHAL are safe procedures and have similar effectiveness for treating grade III hemorrhoid;s however DGHAL is less painful and provides earlier functional recovery but is associated with higher recurrence rates and lower satisfaction rates compared with SH. 相似文献6.
7.
8.
Yohann Avital Kayange Linda Purcell Laura N. Gallaher Jared Charles Anthony 《World journal of surgery》2022,46(3):504-511
World Journal of Surgery - Trauma is a leading cause of morbidity and mortality worldwide, and patients in low- and middle-income countries are disproportionately affected. Organized trauma... 相似文献
9.
Kent Ilan Geffen Noa Stein Assaf Rudnicki Yaron Friehmann Asaf Avital Shmuel 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(3):607-611
Graefe's Archive for Clinical and Experimental Ophthalmology - Colonoscopy is an endoscopic examination of the bowel. It requires insufflation of the large bowel lumen with gas which leads to... 相似文献
10.
Smith-Whitley K Zhao H Hodinka RL Kwiatkowski J Cecil R Cecil T Cnaan A Ohene-Frempong K 《Blood》2004,103(2):422-427
Human parvovirus (HPV) B19 causes significant morbidity and mortality in children with sickle cell disease (SCD), but little data are published about the epidemiology of HPV B19 infection and its associated complications in this patient population. In this study, prevalence and incidence rates of HPV B19 were determined in 633 patients with SCD followed at The Children's Hospital of Philadelphia between November 1996 and December 2001. Thirty percent (30%) were HPV B19 immunoglobulin G (IgG) positive at first testing, and the 70% without evidence of past HPV B19 infection were tested annually. One hundred ten patients developed evidence of HPV B19 infection for an incidence rate of 11.3 per 100 patient years. Sixty-eight episodes of HPV B19-induced transient red cell aplasia occurred with the following clinical events: fever (89.7%), pain (61.8%), acute splenic sequestration (19.1%), and acute chest syndrome (11.8%). Pain, fever, and acute splenic sequestration were more frequent events with acute HPV B19 infections compared with acute events in uninfected patients. The results of this epidemiologic study, the largest and most comprehensive to date, justify the development of HPV B19 prevention strategies to diminish the frequent and often severe complications associated with HPV B19 infections in patients with SCD. 相似文献