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目的 探讨可溶性白细胞分化抗原14(soluble cluster of differentiation antigen 14,sCD14)、血管生成素2(angiopoietin 2,Ang2)、C反应蛋白(C-reactive protein,CRP)与急诊创伤骨折伴多发伤患者病情转归的关系及意义。
方法 选取创伤骨折伴多发伤患者324例,根据患者出院时病情转归情况分为良好组(275例)、不良组(49例),比较2组一般资料、sCD14、Ang2、CRP水平,应用Pearson分析sCD14、Ang2、CRP与损伤严重程度评分(injury severity score,ISS)关系,采用Cox回归分析急诊创伤骨折伴多发伤患者病情转归的相关影响因素,采用受试者工作特征曲线(receiver operating characteristic,ROC)分析sCD14、Ang2、CRP对病情转归预测价值。
结果 不良组ISS评分高于良好组(P<0.05);不良组sCD14、Ang2、CRP高于良好组(P<0.05);sCD14(r=0.785)、Ang2(r=0.778)、CRP(r=0.842)与ISS评分呈正相关(P<0.05);sCD14、Ang2、CRP均是预后相关独立危险因素(P<0.05);sCD14、Ang2、CRP预测病情转归的ROC下面积(area under the curve,AUC)依次为0.813、0.757、0.749;挑选出预测敏感度最高(sCD14)、特异度最高(Ang2)的两个指标进行sCD14+Ang2的联合ROC分析显示,两者联合预测病情转归的AUC为0.935,大于任一单一指标(P<0.05)。
结论 sCD14、Ang2、CRP与急诊创伤骨折伴多发伤患者病情严重程度及病情转归有关,均可作为预测病情转归的标志物,但联合检测sCD14、Ang2能提高预测可靠性,为临床诊疗及护理提供更准确的参考信息。 相似文献
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MMP-26在子宫内膜瘤和子宫内膜癌中的表达的研究 总被引:1,自引:0,他引:1
基质金属蛋白酶家族在肿瘤细胞的浸润、发生和生长过程中起着非常重要的作用。本研究通过用免疫组化的方法对MMP-26在子宫内膜癌和子宫内膜肿瘤的整个月经周期中的分布与定位以及对MMP-26与子宫内膜瘤各亚型、分期和级别之间的关系进行了研究。研究发现,MMP-26在子宫内膜癌和子宫内膜瘤月经周期的不同阶段均有表达。而且,在绝经后,MMP-26在子宫内膜癌中的表达强于子宫内膜瘤中的表达,而不是在月经周期的分泌期。MMP一26在子宫内膜上皮细胞中的表达最强,其次是血管上皮细胞,子宫肌层的平滑肌细胞和子宫内膜基质细胞。并且随着肿瘤的浸润深度和根据FIGO划分的肿瘤级别的升高MMP-26的表达增强。所以,MMP-26在子宫内膜和子宫内膜癌中的分布与表达说明MMP-26在子宫内膜肿瘤的发生上起着非常重要的作用。 相似文献
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Objective To establish the reference range of venous blood cells of healthy aged people by means of investigation on the reference range of venous blood cells of healthy adults and the aged.Methods The parameters of 3302 venous blood samples from the healthy adults and the aged were analyzed by applying SymexKX-21N hematology analyzer,and the test results were statistically analyzed with SPSS10.0 software.Results The reference range of the healthy aged people(males and females):WBC(3.57-9.00)×109/L and(3.52-8.39)×109/L;RBC(3.78-5.42)×1012/L and (3.44-4.83)×1012/L;hemoglobin(Hb)121.40-168.10 and 107.90-147.90 g/L;hematocrit(HCT)36.62%-49.18% and 32.82%-44.03%;mean corpuscular volume(MCV)85.10-100.60 and 84.70-100.60 fL;mean corpuscular hemoglobin(MCH)28.54-34.48 and 28.20-34.10 pg;mean corpuscular hemoglobin concentration(MCHC)322.00-357.00 and 320.00-352.00 pg/L;coefficient of variation of red blood cell distribution width(RDW-CV)12.13%-15.10% and 10.20%-17.12%;platelet(PLT)(70.00-240.00)×109/L and(77.00-262.00)×109/L;mean platelet volume(MPV)9.77-15.37 and 9.51-15.55 fL;platelet distribution width(PDW)11.44%-27.77%;platelet hematocrit(PCT)1.10-2.73 and 1.13-2.99 mL/L;large platelet ratio(P-LCR)24.35%-70.14%.The differences of the parameters(WBC,RBC,Hb,HCT,MCHC,PLT and PCT)were statistically significant between senile males and senile females(P<0.01),while the other parameters weren't(P>0.05);the differences of parameters(WBC,MPV,PDW and P-LCR)were not significant between adults and the ageds(P>0.05),while the other parameters were(P<0.05).There were also significant differences(P<0.05)between the test results and the reported date about the blood cell parameters of adults and the ageds.Conclusion The reference range of the healthy ageds is different from that of adults;therefore it is necessary to establish the laboratory reference range of venous blood cells of the elderly in this region scientifically and rationally. 相似文献
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Objective To establish the reference range of venous blood cells of healthy aged people by means of investigation on the reference range of venous blood cells of healthy adults and the aged.Methods The parameters of 3302 venous blood samples from the healthy adults and the aged were analyzed by applying SymexKX-21N hematology analyzer,and the test results were statistically analyzed with SPSS10.0 software.Results The reference range of the healthy aged people(males and females):WBC(3.57-9.00)×109/L and(3.52-8.39)×109/L;RBC(3.78-5.42)×1012/L and (3.44-4.83)×1012/L;hemoglobin(Hb)121.40-168.10 and 107.90-147.90 g/L;hematocrit(HCT)36.62%-49.18% and 32.82%-44.03%;mean corpuscular volume(MCV)85.10-100.60 and 84.70-100.60 fL;mean corpuscular hemoglobin(MCH)28.54-34.48 and 28.20-34.10 pg;mean corpuscular hemoglobin concentration(MCHC)322.00-357.00 and 320.00-352.00 pg/L;coefficient of variation of red blood cell distribution width(RDW-CV)12.13%-15.10% and 10.20%-17.12%;platelet(PLT)(70.00-240.00)×109/L and(77.00-262.00)×109/L;mean platelet volume(MPV)9.77-15.37 and 9.51-15.55 fL;platelet distribution width(PDW)11.44%-27.77%;platelet hematocrit(PCT)1.10-2.73 and 1.13-2.99 mL/L;large platelet ratio(P-LCR)24.35%-70.14%.The differences of the parameters(WBC,RBC,Hb,HCT,MCHC,PLT and PCT)were statistically significant between senile males and senile females(P<0.01),while the other parameters weren't(P>0.05);the differences of parameters(WBC,MPV,PDW and P-LCR)were not significant between adults and the ageds(P>0.05),while the other parameters were(P<0.05).There were also significant differences(P<0.05)between the test results and the reported date about the blood cell parameters of adults and the ageds.Conclusion The reference range of the healthy ageds is different from that of adults;therefore it is necessary to establish the laboratory reference range of venous blood cells of the elderly in this region scientifically and rationally. 相似文献
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