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排序方式: 共有647条查询结果,搜索用时 15 毫秒
1.
Patrizia Tiberi-Vipraio 《Industry and innovation》1996,3(2):103-104
This paper reviews the scholarship concerning the rise to economic prominence of the Italian industrial districts, and the causes of some of the difficulties in which some districts have found themselves since the mid-1980s. The paper develops the main lines of the economic advantages that districts enjoyed during a period of rapid growth, resulting from the operation of a market in common which blends competition and cooperation. The effects of globalisation are changing this somewhat ‘idyllic’ picture, as the structure of linkages between firms comes under pressure. Prospects for the Italian districts in these new circumstances are discussed. 相似文献
2.
Damiana Chinese Antonella Meneghetti Gioacchino Nardin Patrizia Simeoni 《国际能源研究杂志》2007,31(9):829-848
A mixed integer linear programming model combined with a more traditional design by scenarios is proposed to optimize facilities size and operation mode of a municipal energy system involving significant civil centres and a hospital. Moving from the need of a new heat and power station for the local hospital due to the construction of new pavilions, the opportunity of involving other centres in the neighbourhood in a distributed cogeneration system is analysed, increasing system complexity step by step. Smaller cogeneration units tailored to hospital needs are rewarding ventures with relatively low risks but, in a country whose traditional power generation systems heavily rely on fossil fuels and where energy policy and market conditions can make it profitable to sell surplus power, district heating systems foster the installation of larger cogenerators and lead thereby to higher profits and to better performance as for primary energy savings and greenhouse gases emission reduction. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
3.
Amati Viviana; Werge Thomas M.; Cattaneo Antonino; Tramontane Anna 《Protein engineering, design & selection : PEDS》1995,8(4):403-408
Substance P G-protein coupled receptor and the antigen recognitionsite of a monoclonal antibody raised against substance P sharea stretch of five contiguous identical amino acids. This observationprompted us to build an atomic model of both the receptor andthe antibody and to analyse their common features. In particular,we report here that a pocket of similar size and compositionis present in both proteins, strongly suggesting a similarityin the mode of binding of both macromolecules to substance P.From the analysis of our models, the available data on the modeof binding of the antibody to substance P and recent data onsubstance P receptor mutants, we concluded that the pocket isvery likely to be involved in binding of the C-terminal 'messagesequence' of the tachykinin. This allowed us to suggest specificsite-directed mutants of the receptor which should shed somelight on the mechanism of peptide recognition by G-protein coupledreceptors. 相似文献
4.
Patrizia Marchese Maria Lombardi Maria Elena Mantione Domenico Baccellieri David Ferrara Roberto Chiesa Ottavio Alfieri Chiara Foglieni 《International journal of molecular sciences》2021,22(8)
Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular components, we and explored the anti-thrombogenic efficacy of blockade of the P2X purinoceptor 7 (P2X7). A confocal blood flow videomicroscopy system was performed on cryosections of internal mammary artery (IMA) or carotid plaque (CPL) determining/localizing platelets and fibrin. Blood from healthy donors elicited thrombi over arterial layers. Confocal microscopy associated thrombus with tissue presence of collagen type I, laminin, fibrin(ogen) and tissue factor (TF). The addition of antibodies blocking TF (aTF) or factor XI (aFXI) to blood significantly reduced fibrin deposition, variable platelet aggregation and aTF + aFXI almost abolished thrombus formation, showing synergy between coagulation pathways. A scarce effect of aTF over sub-endothelial regions, more abundant in tissue TF and bundles of laminin and collagen type I than deep intima, may suggest tissue thrombogenicity as molecular structure-related. Consistently with TF-related vascular function and expression of P2X7, the sections from CPL but not IMA tissue cultures pre-treated with the P2X7 antagonist A740003 demonstrated poor thrombogenesis in flow experiments. These data hint to local targeting studies on P2X7 modulation for atherothrombosis prevention/therapy. 相似文献
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6.
Ornella Rondinone Alessio Murgia Jole Costanza Silvia Tabano Margherita Camanni Luigi Corsaro Laura Fontana Patrizia Colapietro Luciano Calzari Silvia Motta Carlo Santaniello Tatjana Radaelli Enrico Ferrazzi Silvano Bosari Davide Gentilini Silvia Maria Sirchia Monica Miozzo 《International journal of molecular sciences》2022,23(10)
7.
Stella Vallejos Polona Umek Toni Stoycheva Fatima Annanouch Eduard Llobet Xavier Correig Patrizia De Marco Carla Bittencourt Chris Blackman 《Advanced functional materials》2013,23(10):1313-1322
Tungsten oxide nanostructures functionalized with gold or platinum NPs are synthesized and integrated, using a single‐step method via aerosol‐assisted chemical vapour deposition, onto micro‐electromechanical system (MEMS)‐based gas‐sensor platforms. This co‐deposition method is demonstrated to be an effective route to incorporate metal nanoparticles (NP) or combinations of metal NPs into nanostructured materials, resulting in an attractive way of tuning functionality in metal oxides (MOX). The results show variations in electronic and sensing properties of tungsten oxide according to the metal NPs introduced, which are used to discriminate effectively analytes (C2H5OH, H2, and CO) that are present in proton‐exchange fuel cells. Improved sensing characteristics, in particular to H2, are observed at 250 °C with Pt‐functionalized tungsten oxide films, whereas non‐functionalized tungsten oxide films show responses to low concentrations of CO at low temperatures. Differences in the sensing characteristics of these films are attributed to the different reactivities of metal NPs (Au and Pt), and to the degree of electronic interaction at the MOX/metal NP interface. The method presented in this work has advantages over other methods of integrating nanomaterials and devices, of having fewer processing steps, relatively low processing temperature, and no requirement for substrate pre‐treatment. 相似文献
8.
Gianluigi De Falco Mario Commodo Carmela Bonavolontà Giovanni Piero Pepe Patrizia Minutolo Andrea D’Anna 《Combustion and Flame》2014
Optical and electrical properties of carbonaceous particles produced in laboratory scale, premixed ethylene/air flames are obtained. Light absorption and Raman spectroscopy show that the change in particle nanostructure follows a graphitization trajectory as the flame richness increases. The optical band gap decreases and the size of the aromatic network in the particle increases, while the interlayer spacing between parallel layers decreases. The electrical conductivity of the materials increases by increasing flame richness in agreement to the graphitization trajectory. A non-ohmic behavior has been found and explained in terms of electron tunneling in a percolative network. Our results show that the electrical properties of flame formed carbon nanoparticles are strongly dependent on their nanostructure, and hence they have to be used carefully for the determination of particle concentration with conductometric sensors. Moreover, the dependence of the electrical properties of combustion formed particles might be useful for the development of cheap sensors for the selective detection of different classes of combustion aerosols. 相似文献
9.
Patrizia Restani Francesca Uberti Roberta Danzi Cinzia Ballabio Francesco Pavanello Chiara Tarantino 《Food chemistry》2012
The possible presence of allergenic residues in wines treated with one of the potassium caseinates used as fining agents has been investigated. 相似文献
10.