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Ladan Mohajeri Farnaz Salehi Payman Mehrvarzfar Hamide Arfaee Behnam Bohluli Reza Hamedy 《Anesthesia progress》2015,62(1):14-19
Achieving adequate pulpal anesthesia in mandibular teeth is always a challenge. Supplementary injections and using drugs in combination are some methods implemented to overcome this hurdle. In this randomized clinical trial, use of meperidine in conjunction with lidocaine in intraligamentary injection did not exhibit significant improvement in anesthesia.Key Words: Periodontal ligament, Meperidine, Irreversible pulpitis, Dental anesthesiaThe failure rate of the inferior alveolar nerve block (IANB) in some experimental studies has been reported up to 75%.1–4 This lack of success has even increased to a maximum of 81% in some recent studies.5–7 To overcome this shortcoming, dental clinicians have actively sought measures to improve the patients'' anesthesia during different dental procedures. Apart from the anatomical variations mentioned in the applied anatomy of injections,8 several authors have attempted to modify the anesthetic technique,9–12 and others have compared different anesthetic agents13 or their concentrations14 to improve their efficacy.Activating the opioid receptors peripherally in inflammatory conditions has become a new trend in research to manage postoperative pain.15 Synergy between local anesthetics and opioids has become an interesting field of research recently.16 Opioids are frequently added to local anesthetics in a variety of surgical procedures, eg, intrathecal application for minor surgery.17 Meperidine or its derivatives, eg, pethidine (meperidine chloride) or norpethidine (Pethidine Intermediate B) are agonists of μ-opioid receptors, which block the pathway of pain signals to the trigeminal nucleus. They also activate peripheral opioid receptors and block sodium channels.17–22 Despite controversy regarding the use of meperidine as an anesthetic,22 recent studies have demonstrated its benefits over prilocaine in arthroscopy with local anesthesia,16 nasal packing removal,23 etc.However, only a few studies have investigated the dental anesthetic efficacy of such combinations.24,25 The effect of the addition of meperidine to lidocaine in IANB for pain management in normal teeth24 and also in teeth with irreversible pulpitis25 has been studied. The aim of our study was to compare the efficacy of local anesthetics with and without meperidine for intraligamentary supplemental injection for teeth with irreversible pulpitis. Our null hypothesis stated that the addition of meperidine to standard lidocaine with epinephrine does not improve the efficacy of supplemental intraligamentary anesthesia in teeth with symptomatic irreversible pulpitis. The specific objectives were to randomly allocate volunteers with complete soft tissue anesthesia following an IANB, yet having positive pulp response, into 2 groups, and then compare the efficacy of lidocaine with epinephrine plus meperidine with that of lidocaine with epinephrine plus an equal volume of sterile water for supplemental periodontal ligament anesthesia. 相似文献
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Musa Ibrahim Adamu Ladan Mu’azu Nura Idris Musa Uba Rabiu Binta Wudil Jibir Kabir Ibrahim Getso Mohammad Aminu Mohammad Femi Luqman Owolabi 《African Journal of Paediatric Surgery》2015,12(1):23-28
Background:
Childhood traumatic brain injury (TBI) has high rate of mortality and morbidity worldwide. There are dearths of reports from developing countries with large paediatric population on trauma; neurosurgery trauma of nonaccidental origin is not an exemption. This study analysed menace of non-accidental TBI in the paediatric population from our center.Materials and Methods:
This is a single unit, retrospective study of the epidemiology of non-accidental TBI in children starting from September, 2008 to March, 2014. The management outcomes of the epidemiology of the non-accidental TBI were analysed.Results:
Total of 109 children age range from 0 (intra-natal) to 16 years with a mean of 5.8 ± 4.6 years (median, 5 years) were enrolled into the study. 34 (31.2%) were domestic violence, 26 (23.9%) street assaults, 16 (14.7%) were due to animal assaults and mishaps, 17 (15.6%) fall from heights. Seven (6.4%) cases of collapsed buildings were also seen during the period. Four (3.7%) industrial accidents and two (1.8%) were self-inflicted injuries. There were also three (2.8%) cases of iatrogenic TBI out of which two infants (1.8%) sustained TBI from cesarean section procedure while one patient (0.9%) under general anaesthesia felt from the operation bed resulting to severe TBI.Conclusion:
Child abuse, unprotected child labour, parental/care-givers negligence are the main cause of nonaccidental TBI. Human right activists and government agents should be incorporated in curtailing the menace. 相似文献4.
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Sara Akhavanfard Sara O. Vargas Moonjoo Han Mai Nitta Clarice B. Chang Long P. Le Ladan Fazlollahi Quan Nguyen Yunqing Ma Arjola Cosper Dora Dias‐Santagata Jae Y. Han Kristin Bergethon Darrell R. Borger Leif W. Ellisen Scott L. Pomeroy Daniel A. Haber Miguel N. Rivera 《Genes, chromosomes & cancer》2014,53(1):67-77
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Ladan Kobari Frank Yates Noufissa Oudrhiri Alain Francina Laurent Kiger Christelle Mazurier Shaghayegh Rouzbeh Wassim El-Nemer Nicolas Hebert Marie-Catherine Giarratana Sabine Fran?ois Alain Chapel Hélène Lapillonne Dominique Luton Annelise Bennaceur-Griscelli Luc Douay 《Haematologica》2012,97(12):1795-1803
Background
Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells from normal and homozygous sickle cell disease donors.Design and Methods
We addressed the question as to whether these cells can reach complete erythroid terminal maturation notably with a complete switch from fetal to adult hemoglobin. Sickle cell disease induced pluripotent stem cells were differentiated in vitro into red blood cells and characterized for their terminal maturation in terms of hemoglobin content, oxygen transport capacity, deformability, sickling and adherence. Nucleated erythroblast populations generated from normal and pathological induced pluripotent stem cells were then injected into non-obese diabetic severe combined immunodeficiency mice to follow the in vivo hemoglobin maturation.Results
We observed that in vitro erythroid differentiation results in predominance of fetal hemoglobin which rescues the functionality of red blood cells in the pathological model of sickle cell disease. We observed, in vivo, the switch from fetal to adult hemoglobin after infusion of nucleated erythroid precursors derived from either normal or pathological induced pluripotent stem cells into mice.Conclusions
These results demonstrate that human induced pluripotent stem cells: i) can achieve complete terminal erythroid maturation, in vitro in terms of nucleus expulsion and in vivo in terms of hemoglobin maturation; and ii) open the way to generation of functionally corrected red blood cells from sickle cell disease induced pluripotent stem cells, without any genetic modification or drug treatment.Key words: human induced pluripotent stem cells, terminal maturation, erythropoietic differentiation 相似文献10.
Najmadini Atefeh Mohammadi Mohammad Mahdi Langroudi Ladan Meimand Hosseinali Ebrahimi Mahmoodi Merat Mirzaei Moghadameh 《Journal of neurovirology》2022,28(4-6):497-504
Journal of NeuroVirology - Multiple sclerosis (MS) is one of the common autoimmune diseases. The exact etiology of MS is still unclear, but recent studies have shown the possibility of infectious... 相似文献