全文获取类型
收费全文 | 7704篇 |
免费 | 715篇 |
国内免费 | 389篇 |
学科分类
医药卫生 | 8808篇 |
出版年
2024年 | 32篇 |
2023年 | 133篇 |
2022年 | 350篇 |
2021年 | 446篇 |
2020年 | 349篇 |
2019年 | 294篇 |
2018年 | 296篇 |
2017年 | 270篇 |
2016年 | 203篇 |
2015年 | 384篇 |
2014年 | 457篇 |
2013年 | 404篇 |
2012年 | 623篇 |
2011年 | 617篇 |
2010年 | 372篇 |
2009年 | 282篇 |
2008年 | 363篇 |
2007年 | 359篇 |
2006年 | 387篇 |
2005年 | 415篇 |
2004年 | 213篇 |
2003年 | 212篇 |
2002年 | 165篇 |
2001年 | 133篇 |
2000年 | 139篇 |
1999年 | 140篇 |
1998年 | 67篇 |
1997年 | 66篇 |
1996年 | 65篇 |
1995年 | 50篇 |
1994年 | 69篇 |
1993年 | 31篇 |
1992年 | 56篇 |
1991年 | 55篇 |
1990年 | 39篇 |
1989年 | 43篇 |
1988年 | 30篇 |
1987年 | 31篇 |
1986年 | 20篇 |
1985年 | 19篇 |
1984年 | 18篇 |
1983年 | 5篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1979年 | 10篇 |
1978年 | 16篇 |
1973年 | 10篇 |
1972年 | 6篇 |
1967年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有8808条查询结果,搜索用时 15 毫秒
1.
AbstractBackground: This study aims to compare the effectiveness of inhaled prostacyclin or its analoguesversus nitric oxide (NO) in treating pulmonary hypertension (PH) after cardiac or pulmonary surgery remains unclear.Methods: PubMed, Cochrane, and Embase databases were searched for literature published prior to December 2019 using the following keywords: inhaled, nitric oxide, prostacyclin, iloprost, treprostinil, epoprostenol, Tyvaso, flolan, and pulmonary hypertension. Randomized controlled trials and multiple-armed prospective studies that evaluated inhaled NO versus prostacyclin (or analogues) in patients for perioperative and/or postoperative PH after either cardiac or pulmonary surgery were included. Retrospective studies, reviews, letters, comments, editorials, and case reports were excluded.Results: Seven studies with a total of 195 patients were included. No difference in the improvement of mean pulmonary arterial pressure (pooled difference in mean change= ?0.10, 95% CI: ?3.98 to 3.78, p?=?.959) or pulmonary vascular resistance (pooled standardized difference in mean change= ?0.27, 95% CI: ?0.60 to 0.05, p?=?.099) were found between the two treatments. Similarly, no difference was found in other outcomes between the two treatments or subgroup analysis.Conclusions: Inhaled prostacyclin (or analogues) was comparable to inhaled NO in treating PH after cardiac or pulmonary surgery.
- Key messages
This study compared the efficacy of inhaled prostacyclin or its analogues versus inhaled NO to treat PH after surgery. The two types of agent exhibited similar efficacy in managing MPAP, PVR, heart rate, and cardiac output was observed.
Inhaled prostacyclin may serve as an alternative treatment option for PH after cardiac or pulmonary surgery.
2.
3.
Cardiotoxin, isolated from the venom of Naja naja atra, was found to cause rat hind-paw edema in a dose-dependent manner. This edematous response was significantly suppressed by pretreatment with diphenhydramine, methysergide or compound 48/80, which reduced the tissue histamine content. Polymorphonuclear (PMN) leukocyte infiltration appeared within 1 h and had accumulated markedly in the rat paw 3-6 h after subplantar injection of cardiotoxin. Methotrexate pretreatment significantly reduced not only the peripheral leukocyte count but also cardiotoxin-induced paw edema. Captopril, a kininase inhibitor, potentiated the edematous response caused by a low dose of cardiotoxin. The initial phase, occurring within 3 h, of paw edema induced by cardiotoxin was suppressed by trasylol, [Thi5,8,D-Phe7]bradykinin, or by cellulose sulfate pretreatment which greatly reduced plasma kininogen levels. Both mast cells and PMN leukocytes possess kinin-forming activities, but with different properties. The kinin-forming activity of mast cells but not of PMN leukocytes was inhibited by trasylol. In isolated mast cells, cardiotoxin caused a dose-dependent release of histamine, beta-glucuronidase, lactate dehydrogenase and kinin-forming activity. These observations suggest that mast cells and PMN leukocytes are involved in cardiotoxin-induced paw edema, and that inflammatory mediators such as histamine, serotonin and kinins were supplied directly or indirectly by mast cells, at least in the initial phase. 相似文献
4.
5.
逆行交锁髓内钉治疗股骨髁上骨折及关节僵硬 总被引:2,自引:0,他引:2
目的:探讨应用逆行交锁强内钉治疗陈旧性股骨碟上骨折钢板断裂不愈合并膝关节僵硬的临床意义。方法:对5例患采用断裂钢板拆除,手术松解粘连,矫正畸形,股骨碟逆行交锁铝内钉固定,术后早期应用CPM机锻炼。结果:5例随访8—12个月,肢体无畸形,骨折愈合时间6—9个月,平均7.5个月,膝关节功能按Kolmert评定标准,优4例,良1例。结论:应用逆行交锁铝内钉治疗股骨碟上陈旧性骨折钢板断裂骨不愈合并膝关节僵硬,操作简便,固定牢靠,可早期功能锻炼,效果良好。 相似文献
6.
7.
8.
9.
目的 探讨在泌尿生殖道有炎症表现的情况下沙眼衣原体 (CT)感染的状况。方法 采用C -C快速法。结果 CT在泌尿生殖道炎症时的阳性率显著高于无炎症表现者 (P <0 .0 5) ;男性在有无炎症表现情况下的CT阳性率差异有显著性 (P <0 .0 5) ,而女性差异无显著性 (P >0 .0 5) ;2 1~ 50岁为高发年龄段。结论 CT感染症状隐匿 ,临床无症状者也应注意CT的检测 ,尤其是女性和高危人群。 相似文献
10.
目的 观察祛瘀消斑胶囊治疗不稳定型心绞痛及对其血浆Fib和DD水平的影响。方法 对 4 0例不稳定型心绞痛患者随机分为常规西药加祛瘀消斑胶囊治疗组 (治疗组 )和常规西药治疗组 (对照组 ) ,治疗组与对照组各 2 0例。采用相应药物治疗 4周后 ,观察 2组患者的临床疗效、心电图改善及硝酸酯类药物的停减率 ,以及血浆Fib、DD水平变化 ,并进行比较分析。结果 治疗组可显著改善心绞痛症状 ,与对照组比较有显著性差异 (P <0 .0 5 ) ,2组患者心电图改善情况及硝酸酯类药物减停率无显著性差异 (P >0 .0 5 )。治疗组降低Fib、DD水平 ,与对照组比较有显著性差异 (P <0 .0 5 )。 2组均未出现明显不良反应。结论 祛瘀消斑胶囊可显著降低不稳定型心绞痛患者Fib、DD水平 ,联合西药治疗不稳定型心绞痛 ,疗效优于单用西药 ,且安全可靠。 相似文献