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Tanhaeian Abbas Jaafari Mahmoud Reza Ahmadi Farajollah Shahriari Vakili‐Ghartavol Roghayyeh Sekhavati Mohammad Hadi 《Probiotics and antimicrobial proteins》2019,11(3):1034-1041
Probiotics and Antimicrobial Proteins - Nowadays, cancer remains a major cause of death affecting millions of people. Currently, the antimicrobial peptides (AMPs) as potent anticancer therapeutic... 相似文献
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Vahideh Ahmadzadeh Safar Farajnia Roghayyeh Baghban Leila Rahbarnia Habib Zarredar 《Journal of cellular biochemistry》2019,120(10):16379-16392
Genome engineering technology is of great interest for biomedical research that enables scientists to make specific manipulation in the DNA sequence. Early methods for introducing double-stranded DNA breaks relies on protein-based systems. These platforms have enabled fascinating advances, but all are costly and time-consuming to engineer, preventing these from gaining high-throughput applications. The CRISPR-Cas9 system, co-opted from bacteria, has generated considerable excitement in gene targeting. In this review, we describe gene targeting techniques with an emphasis on recent strategies to improve the specificities of CRISPR-Cas systems for nuclease and non-nuclease applications. 相似文献
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Seyfi Roghayyeh Kahaki Fatemeh Abarghooi Ebrahimi Tahereh Montazersaheb Soheila Eyvazi Shirin Babaeipour Valiollah Tarhriz Vahideh 《International journal of peptide research and therapeutics》2020,26(3):1451-1463
International Journal of Peptide Research and Therapeutics - Antimicrobial peptides (AMPs) are a crucial part of innate immunity that exist in the most of living organisms. In fact, AMPs have... 相似文献
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Habib Zarredar Shadi Pashapour Khalil Ansarin Majid Khalili Roghayyeh Baghban Safar Farajnia 《Journal of cellular physiology》2019,234(2):1560-1566
Lung cancer is a leading cause of cancer-related deaths worldwide, with less than a 5-year survival rate for both men and women. Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma oncogene (KRAS) signaling pathways play a critical role in the proliferation and progression of various cancers, including lung cancer. Genetic studies have shown that amplification, over-expression, or mutation of EGFR is an early and major molecular event in many human tumors. KRAS mutation is a negative factor in various cancer, including non-small-cell lung cancer, and complicates therapeutic approaches with adjuvant chemotherapy and anti-EGFR directed therapies. This article is dedicated to evaluating the synergistic effect of a novel EGFR inhibitor AZD8931 and KRAS small interfering RNA (siRNA) on the proliferation and apoptosis of lung adenocarcinoma cancer cells. A549 lung cancer cells were treated with KRAS siRNA and the EGFR inhibitor alone or in combination. The cytotoxic effects of KRAS siRNA and te EGFR inhibitor were determined usingMTT assay, and induction of apoptosis was determined by FACS analysis. Suppression of KRAS, Her-2, and EGFR expression by treatments was measured by qRT-PCR and western blotting. KRAS siRNA and the EGFR inhibitor significantly reduced the proliferation of A549 cells as well as KRAS and EGFR mRNA levels 24 hr after treatment. The results also indicated that the silencing of KRAS and EGFR has synergistic effects on the induction of apoptosis on the A549 cells. These results indicated that KRAS and EGFR might play important roles in the progression of lung cancer and could be potential therapeutic targets for treatment of lung cancer. 相似文献
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Baghban Roghayyeh Ghasemali Samaneh Farajnia Safar Hoseinpoor Reyhaneh Andarzi Sahar Zakariazadeh Mostafa Zarredar Habib 《International journal of peptide research and therapeutics》2021,27(4):2245-2256
International Journal of Peptide Research and Therapeutics - The vascular endothelial growth factor (VEGF) signaling pathway has a crucial role in regulating tumor angiogenesis. VEGF-A shows... 相似文献
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