全文获取类型
收费全文 | 876篇 |
免费 | 182篇 |
国内免费 | 2篇 |
学科分类
医药卫生 | 1060篇 |
出版年
2024年 | 4篇 |
2023年 | 54篇 |
2022年 | 5篇 |
2021年 | 22篇 |
2020年 | 44篇 |
2019年 | 19篇 |
2018年 | 66篇 |
2017年 | 55篇 |
2016年 | 52篇 |
2015年 | 47篇 |
2014年 | 83篇 |
2013年 | 86篇 |
2012年 | 56篇 |
2011年 | 53篇 |
2010年 | 64篇 |
2009年 | 85篇 |
2008年 | 46篇 |
2007年 | 35篇 |
2006年 | 45篇 |
2005年 | 21篇 |
2004年 | 25篇 |
2003年 | 13篇 |
2002年 | 21篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 9篇 |
1998年 | 7篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有1060条查询结果,搜索用时 0 毫秒
1.
2.
Osteochondral Fracture of the Fourth Metatarsal Head Treated by Open Reduction and Internal Fixation
Praveen K.R. Mereddy MBBS MSOrth DNB Orth MRCSEd Andrew Molloy MBchB MRCS FRCS Michael S. Hennessy BSc MBchB FRCSEd 《The Journal of foot and ankle surgery》2007,46(4):320-322
Fracture of the metatarsal head is uncommon, and reports of isolated osteochondral fracture of the metatarsal head are rare. Because of the distal location of the fracture, it is difficult to achieve and maintain reduction, and potential complications include avascular necrosis and subchondral fatigue fracture. The authors present a case of an osteochondral fracture in a 40-year-old man, which was treated by open reduction and internal fixation with a single twist-off screw, with good results 12 months postoperatively. 相似文献
3.
4.
Manisha Garella MS DNB B. Ghosh MD MNAMS Meenakshi Thakar MD Sonu Nigarn MD Rajeev Jain MBBS 《Annals of Ophthalmology》2004,36(1):59-62
A case of a child with bilateral fleshy limbal masses with a coloboma of the right upper lid is discussed. Systemic examination
revealed two patches of alopecia on the right frontoparietal and right occipital areas of the scalp. Punch biopsy and histopathological
examination led to the diagnosis of Linear Nevus Sebaceus Syndrome (LNSS) with bilateral complex limbal choristomas.
The authors have stated that they do not have a significant financial interest or other relatioship with any product manufacturer
or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes
unlabeled, unapproved, or investigative products or devices. 相似文献
5.
6.
7.
Mukesh Kalra MS Asif Mahmood MRCS Mohit Kumar Patralekh MS DNB 《Journal of Clinical Orthopaedics and Trauma》2011,2(1):46-50
Management of femoral diaphyseal fractures in the age group of 6-16 years is controversial. There has been a resurgence worldwide for operative fixation in general and TENS (titanium elastic nailing system) in particular.We performed a retrospective review of pediatric femoral fractures treated by TENS. The data was collected from cases operated between July 2007 and June 2010 at Sohar Hospital, Oman.We had treated 16 children (14 boys and 2 girls) with TENS for femoral shaft fractures. The mean age was 12.5 years (range 7-16 years) and mean hospital stay was 7.6 days (range 4-15 days). All fractures were radio-graphically united at a mean of 7.5 weeks (range 5-10 weeks). The nails were removed in 14 children after a mean of 22 weeks (range 6-38 weeks) postoperatively. At follow-up, we had found leg length discrepancy of 1 cm in one child and 10° of internal rotational deformity in another. No angular deformity had occurred.Titanium elastic nailing seems to be a safe and effective method for the treatment of femoral shaft fractures in children between 7 and 16 years of age. 相似文献
8.
9.
10.
Shrikant R Mulay Dana Thomasova Mi Ryu Onkar P Kulkarni Adriana Migliorini Hauke Bruns Regina Gröbmayr Elena Lazzeri Laura Lasagni Helen Liapis Paola Romagnani Hans‐Joachim Anders 《The Journal of pathology》2013,230(3):322-335
Podocyte apoptosis as a pathway of podocyte loss is often suspected but rarely detected. To study podocyte apoptosis versus inflammatory forms of podocyte death in vivo, we targeted murine double minute (MDM)‐2 for three reasons. First, MDM2 inhibits p53‐dependent apoptosis; second, MDM2 facilitates NF‐κB signalling; and third, podocytes show strong MDM2 expression. We hypothesized that blocking MDM2 during glomerular injury may trigger p53‐mediated podocyte apoptosis, proteinuria, and glomerulosclerosis. Unexpectedly, MDM2 blockade in early adriamycin nephropathy of Balb/c mice had the opposite effect and reduced intra‐renal cytokine and chemokine expression, glomerular macrophage and T‐cell counts, and plasma creatinine and blood urea nitrogen levels. In cultured podocytes exposed to adriamycin, MDM2 blockade did not trigger podocyte death but induced G2/M arrest to prevent aberrant nuclear divisions and detachment of dying aneuploid podocytes, a feature of mitotic catastrophe in vitro and in vivo. Consistent with these observations, 12 of 164 consecutive human renal biopsies revealed features of podocyte mitotic catastrophe but only in glomerular disorders with proteinuria. Furthermore, delayed MDM2 blockade reduced plasma creatinine levels, blood urea nitrogen, tubular atrophy, interstitial leukocyte numbers, and cytokine expression as well as interstitial fibrosis. Together, MDM2‐mediated mitotic catastrophe is a previously unrecognized variant of podocyte loss where MDM2 forces podocytes to complete the cell cycle, which in the absence of cytokinesis leads to podocyte aneuploidy, mitotic catastrophe, and loss by detachment. MDM2 blockade with nutlin‐3a could be a novel therapeutic strategy to prevent renal inflammation, podocyte loss, glomerulosclerosis, proteinuria, and progressive kidney disease. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献