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借助2007年儿科麻醉学大会成功举办的契机,先天性心脏病麻醉协会(The Congenital Cardiac Anesthesia Society,CCAS)在亚利桑那州菲尼克斯市成立,并召开了第一次会议。儿科心脏病重症监护协会(PICU)在此之前成功举办了两个关于儿科心脏病麻醉的会议,为CCAS的成立奠定了基础。今后,CCAS年会将分别与冬季儿科麻醉协会(Winter Socity for Pediatric Anesthesia)庄羡国儿科学会赞助的儿科麻醉协会和儿科心脏病重症监护协会轮流召开年会。 相似文献
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目的 观察不同人工胶体液行急性超容血液稀释(AHHD)对血流动力学的影响.方法 45例ASA Ⅰ~Ⅱ级腹部手术患者,随机分为3组:对照组(C组)、6%羟乙基淀粉组(H组)及4%琥珀酰明胶组(G组).在麻醉诱导后开始输液或扩容:C组输入林格液15 ml/kg,H、G组输入林格液15 ml/kg和胶体液20 ml/kg,均在40 min内完成.监测3组术前、麻醉诱导后、输液或扩容20 min、输液或扩容40 min时心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)、心脏指数(CI),外周血管阻力(SVR)的变化.监测H、G组患者扩容前后血细胞比容(Hct)的变化.结果 H、G组在扩容末,Hct下降,H组由术前0.385±0.043降至0.304±0.045,G组由术前0.395±0.035降至0.312±0.038.H、G组HR、MAP、CI、CVP、SVR术前值和麻醉诱导后值与C组的差异没有统计学意义(P>0.05).输液或扩容20 min、输液或扩容40 min时H、G组HR、CI、CVP、MAP高于C组,其差异有统计学意义(P<0.05);在扩容20 ml/kg后H组CVP增高达(13.13±3.51)cm H2O(1 cm H2O=0.098 kPa),G组增加达(14.88±1.33)cm H2O.结论 在40 min内静脉输入20 ml/kg的6%羟乙基淀粉、4%琥珀酰明胶,是一种有效的超容血液稀释方法.但会造成心脏负荷的显著增加,使用异氟醚和硝酸甘油能有效地减轻心脏前负倚. 相似文献
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目的观察缺血后处理对小肠缺血再灌注损伤的保护作用。方法30只大白兔随机分为3组,每组8只:A组,假手术组;B组,肠缺血再灌注损伤模型组;C组,肠缺血再灌注损伤模型肠缺血后处理组,实验结束后取小肠标本进行小肠上皮细胞形态和呼吸功能指标测定。结果A、C两组线粒体的数目、周长均大于B组,A、C两组问比较,A组较大(P〈0.05)。A、C两组线粒体的面积、最大直径、最小直径、等效直径均小于B组(P〈0.05),A、C两组间比较差异无统计学意义(P〉0.05)。B组线粒体的体积密度小于A组,面积密度、比表面和粒子数密度均小于其余两组(P〈0.05)。A、C两组间三维平面形态计量学各参数比较差异无统计学意义(P〉0.05);B、C组线粒体呼吸控制比率(RCR)低于A组差异有统计学意义(P〈0.05),与C组比较,B组下降更为明显(P〈0.05)。结论小肠缺血后处理对缺血再灌注损伤肠上皮细胞线粒体形态和功能均有保护作用。 相似文献
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Objective To evaluate the effects of ischemic preconditioning-postconditioning on the intestinal ischemia-reperfusion (IR) injury in rats. Methods Forty healthy male SD weighing 225-275 g were randomly assigned into 5 groups ( n = 8 each): group I sham operation (group S) ; group II intestinal IR (group IIR); group Ⅲ ischemic preconditioning (group Ipr); group IV ischemic postconditioning (group Ipo); group V Ipr+ Ipo. The rats were anesthetized with intraperitonel 20% urethane 5 ml/kg. Superior mesenteric artery (SMA) was occluded for 60 min followed by 60 min reperfusion. In group S, SMA was isolated but not occluded. In group Ipr, SMA was occluded for 10 min followed by 10 min reperfusion, and the rest procedures were performed using the method described in group IIR. In group Ipo, 60 min ischemia was followed by three 30 s episodes of ischemia at 30 s intervals for reperfusion. In group Ipr+ Ipo, Ipr was performed followed by Ipo and the procedures were performed using the methods described in group Ipr and Ipo. The animals were killed at 60 min of reperfusion. The intestinal tissues were immediately removed for determination of MDA content, SOD and MPO activities and the degree of damage to intestinal mucous membrane was scored according to Chiu score. Arterial blood samples were taken for determination of plasma concentrations of TNF-α and 1L-6. Results Compared with group S, Chiu score, MDA content, MPO activity, and plasma concentrations of TNF-α and IL-6 were significantly increased, whereas SOD activity decreased in the other 4 groups ( P < 0.05). Chiu score, MDA content, MPO activity, and plasma concentrations of TNF-α and IL-6 were significantly decreased, whereas SOD activity increased in group Ipr, Ipo and Ipr + Ipo as compared with group IIR ( P < 0.05). Chiu score and MDA content were significantly lower, whereas SOD activity higher in group Ipr + Ipo than in group Ipr and Ipo ( P < 0.05). No significant differences were detected in the indices between group Ipr and group Ipo ( P > 0.05). Conclusion Ischemic preconditioning-postconditioning can attenuate the intestinal IR injury in rats, and the efficacy is better than that of either Ipr or Ipo alone. 相似文献
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3、醛脱氢酶和醛糖还原酶,前3种酶与改善能量代谢相关,后3种酶与抗氧化应激、抑制凋亡相关.结论 建立了重复性较好的正常与II/R损伤后大鼠肠黏膜组织的双向凝胶电泳图谱.II/R的损伤机制可能与顺乌头酸酶、丙酮酸激酶、细胞色素C还原酶、蛋白二硫化物异构酶A3、醛脱氧酶和醛糖还原酶的下调有关. 相似文献
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【目的】 检测人β防御素-2(hBD-2)在正常子宫内膜65380;子宫内膜异位症(内异症)患者的在位和异位内膜组织中的表达,探讨hBD-2在内异症发病中的作用65377;【方法】 选择25例内异症患者的卵巢异位内膜组织(异位内膜组)和相应的在位子宫内膜(在位内膜组),以及25例非子宫内膜异位症的子宫肌瘤患者(对照组)的子宫内膜组织65377;采用实时荧光定量PCR(Real-Time PCR)和原位杂交技术检测各组内膜组织中hBD-2的基因表达,以及hBD-2在内异症不同临床分期的异位内膜和在位内膜组织中的表达差异65377;【结果】 异位内膜组内膜组织中hBD-2的基因表达水平显著高于在位内膜组和对照组(P < 0.05)65377;在位内膜组和对照组子宫内膜组织中hBD-2的基因表达水平,差异无统计学意义(P > 0.05)65377;异位内膜组中,hBD-2临床分期表达为Ⅰ期高于Ⅲ期和Ⅳ期65380;Ⅱ期高于Ⅲ期和Ⅳ期,差异有统计学意义(P < 0.05)65377; 【结论】 异位内膜组织中hBD-2的高表达可能参与了内异症的发病65377; 相似文献
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Objective To evaluate the effects of ischemic preconditioning-postconditioning on the intestinal ischemia-reperfusion (IR) injury in rats. Methods Forty healthy male SD weighing 225-275 g were randomly assigned into 5 groups ( n = 8 each): group I sham operation (group S) ; group II intestinal IR (group IIR); group Ⅲ ischemic preconditioning (group Ipr); group IV ischemic postconditioning (group Ipo); group V Ipr+ Ipo. The rats were anesthetized with intraperitonel 20% urethane 5 ml/kg. Superior mesenteric artery (SMA) was occluded for 60 min followed by 60 min reperfusion. In group S, SMA was isolated but not occluded. In group Ipr, SMA was occluded for 10 min followed by 10 min reperfusion, and the rest procedures were performed using the method described in group IIR. In group Ipo, 60 min ischemia was followed by three 30 s episodes of ischemia at 30 s intervals for reperfusion. In group Ipr+ Ipo, Ipr was performed followed by Ipo and the procedures were performed using the methods described in group Ipr and Ipo. The animals were killed at 60 min of reperfusion. The intestinal tissues were immediately removed for determination of MDA content, SOD and MPO activities and the degree of damage to intestinal mucous membrane was scored according to Chiu score. Arterial blood samples were taken for determination of plasma concentrations of TNF-α and 1L-6. Results Compared with group S, Chiu score, MDA content, MPO activity, and plasma concentrations of TNF-α and IL-6 were significantly increased, whereas SOD activity decreased in the other 4 groups ( P < 0.05). Chiu score, MDA content, MPO activity, and plasma concentrations of TNF-α and IL-6 were significantly decreased, whereas SOD activity increased in group Ipr, Ipo and Ipr + Ipo as compared with group IIR ( P < 0.05). Chiu score and MDA content were significantly lower, whereas SOD activity higher in group Ipr + Ipo than in group Ipr and Ipo ( P < 0.05). No significant differences were detected in the indices between group Ipr and group Ipo ( P > 0.05). Conclusion Ischemic preconditioning-postconditioning can attenuate the intestinal IR injury in rats, and the efficacy is better than that of either Ipr or Ipo alone. 相似文献