Mobile phones are rapidly becoming the most widespread and popular form of communication; thus, they are also the most important attack target of malware. The amount of malware in mobile phones is increasing exponentially and poses a serious security threat. Google’s Android is the most popular smart phone platforms in the world and the mechanisms of permission declaration access control cannot identify the malware. In this paper, we proposed an ensemble machine learning system for the detection of malware on Android devices. More specifically, four groups of features including permissions, monitoring system events, sensitive API and permission rate are extracted to characterize each Android application (app). Then an ensemble random forest classifier is learned to detect whether an app is potentially malicious or not. The performance of our proposed method is evaluated on the actual data set using tenfold cross-validation. The experimental results demonstrate that the proposed method can achieve a highly accuracy of 89.91%. For further assessing the performance of our method, we compared it with the state-of-the-art support vector machine classifier. Comparison results demonstrate that the proposed method is extremely promising and could provide a cost-effective alternative for Android malware detection.
Protein-protein interactions (PPIs) occur at almost all levels of cell functions and play crucial roles in various cellular processes. Thus, identification of PPIs is critical for deciphering the molecular mechanisms and further providing insight into biological processes. Although a variety of high-throughput experimental techniques have been developed to identify PPIs, existing PPI pairs by experimental approaches only cover a small fraction of the whole PPI networks, and further, those approaches hold inherent disadvantages, such as being time-consuming, expensive, and having high false positive rate. Therefore, it is urgent and imperative to develop automatic in silico approaches to predict PPIs efficiently and accurately. In this article, we propose a novel mixture of physicochemical and evolutionary-based feature extraction method for predicting PPIs using our newly developed discriminative vector machine (DVM) classifier. The improvements of the proposed method mainly consist in introducing an effective feature extraction method that can capture discriminative features from the evolutionary-based information and physicochemical characteristics, and then a powerful and robust DVM classifier is employed. To the best of our knowledge, it is the first time that DVM model is applied to the field of bioinformatics. When applying the proposed method to the Yeast and Helicobacter pylori (H. pylori) datasets, we obtain excellent prediction accuracies of 94.35% and 90.61%, respectively. The computational results indicate that our method is effective and robust for predicting PPIs, and can be taken as a useful supplementary tool to the traditional experimental methods for future proteomics research. 相似文献
This work investigates a simple and practical bio-immune optimization approach to solve a kind of chance-constrained programming problem without known noisy attributes, after probing into a lower bound estimate of sample size for any random variable. Such approach mainly consists of sample allocation, evaluation, proliferation and mutation. The former two, depending on a lower bound estimate acquired, not only decide the sample size of random variable and the importance level of each evolving B cell, but also ensure that such B cell is evaluated with low computational cost; the third makes diverse B cells participate in evolution and suppresses the influence of noise; the last, which associates with the information on population diversity and fitness inheritance, creates diverse and high-affinity B cells. Under such approach, three similar immune algorithms are derived after selecting different mutation rules. The experiments, by comparison against two valuable genetic algorithms, have illustrated that these immune algorithms are competitive optimizers capable of effectively executing noisy compensation and searching for the desired optimal reliable solution. 相似文献
Protein-Protein Interactions (PPIs) play essential roles in most cellular processes. Knowledge of PPIs is becoming increasingly more important, which has prompted the development of technologies that are capable of discovering large-scale PPIs. Although many high-throughput biological technologies have been proposed to detect PPIs, there are unavoidable shortcomings, including cost, time intensity, and inherently high false positive and false negative rates. For the sake of these reasons, in silico methods are attracting much attention due to their good performances in predicting PPIs. In this paper, we propose a novel computational method known as RVM-AB that combines the Relevance Vector Machine (RVM) model and Average Blocks (AB) to predict PPIs from protein sequences. The main improvements are the results of representing protein sequences using the AB feature representation on a Position Specific Scoring Matrix (PSSM), reducing the influence of noise using a Principal Component Analysis (PCA), and using a Relevance Vector Machine (RVM) based classifier. We performed five-fold cross-validation experiments on yeast and Helicobacter pylori datasets, and achieved very high accuracies of 92.98% and 95.58% respectively, which is significantly better than previous works. In addition, we also obtained good prediction accuracies of 88.31%, 89.46%, 91.08%, 91.55%, and 94.81% on other five independent datasets C. elegans, M. musculus, H. sapiens, H. pylori, and E. coli for cross-species prediction. To further evaluate the proposed method, we compare it with the state-of-the-art support vector machine (SVM) classifier on the yeast dataset. The experimental results demonstrate that our RVM-AB method is obviously better than the SVM-based method. The promising experimental results show the efficiency and simplicity of the proposed method, which can be an automatic decision support tool. To facilitate extensive studies for future proteomics research, we developed a freely available web server called RVMAB-PPI in Hypertext Preprocessor (PHP) for predicting PPIs. The web server including source code and the datasets are available at http://219.219.62.123:8888/ppi_ab/. 相似文献