Perspectives on Design and Innovation

A series of studies of top European and other firms has revealed patterns of design management associated with commercial success. Firms that invest resources and professional expertise in product and industrial design in traditional and new industries have been commercially more successful than firms that pay less attention to these aspects of design. As an industry matures there is a shift in emphasis from design associated with technological innovation, to designs supporting technical improvements, and then to supporting user needs, fashion and product variants. These issues are illustrated through the history of the evolution of the bicycle.     

Note: The intermodulation lockin analyzer

Nonlinear systems can be probed by driving them with two or more pure tones while measuring the intermodulation products of the drive tones in the response. We describe a digital lockin analyzer which is designed explicitly for this purpose. The analyzer is implemented on a field-programmable gate array, providing speed in analysis, real-time feedback, and stability in operation. The use of the analyzer is demonstrated for intermodulation atomic force microscopy. A generalization of the intermodulation spectral technique to arbitrary drive waveforms is discussed.     

Effects of environmental temperature and humidity on thermal flying height adjustment

Thermal actuated sliders are being widely used in today’s hard disk drive industry for its advantages of easier control of flying height (FH) and less risk of contacts with the disk. This article uses a coupled-field analysis method, which includes an air bearing model, a heat transfer model and a thermal-structural finite element model to investigate the FH changes of thermal actuated sliders at various environmental conditions. The mechanism of water vapour’s contribution to air bearing pressure loss is explained and a new humidity model is proposed to calculate this pressure loss. The temperature effects are also considered in the simulation models. It is observed that the environmental temperature and humidity have significant effects on slider’s FH changes, but their effects on the thermal protrusion height are limited. A humidity sensitivity study is also made and the results are discussed. It is found that the slider with thermal protrusion on its trailing pad will be more sensitive to the humidity. Besides air bearing stiffness, some other factors such as peak pressure, protrusion shape and air bearing surface (ABS) design will also contribute to the slider’s humidity sensitivity.     

Engineered Immature Testicular Tissue by Electrospun Mats for Prepubertal Fertility Preservation in a Bioluminescence Imaging Transgenic Mouse Model

Prepubertal boys with cancer may suffer from reduced fertility and maturity following gonadotoxic chemoradiotherapy. Thus, a viable method of immature testicular tissue (ITT) preservation is required in this cohort. In this study, we used poly-L-lactic acid electrospun scaffolds with two levels of fineness to support the development of ITT transplanted from transgenic donors to wild-type recipient mice. The purpose of this study was to evaluate the potential of ITT transplantation and spermatogenesis after using the two scaffolds, employing bioluminescence imaging for evaluation. The results suggest that ITT from 4-week-old mice possessed the most potential in spermatogenesis on the 70th day, together with the fine electrospun scaffolds. Moreover, bioluminescent imaging intensity was observed in recipient mice for up to 107 days, approximately six times more than the coarse electrospun scaffold and the control group. This occurs since the fine scaffold is more akin to the microenvironment of native testicular tissue as it reduces stiffness resulting from micronization and body fluid infiltration. The thermal analysis also exhibited recrystallization during the biodegradation process, which can lead to a more stable microenvironment. Overall, these findings present the prospect of fertility preservation in prepubertal males and could serve as a framework for future applications.     

Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation

Siponimod (Mayzent^®), a sphingosine 1-phosphate receptor (S1PR) modulator which prevents lymphocyte egress from lymphoid tissues, is approved for the treatment of relapsing-remitting and active secondary progressive multiple sclerosis. It can cross the blood–brain barrier (BBB) and selectively binds to S1PR1 and S1PR5 expressed by several cell populations of the central nervous system (CNS) including microglia. In multiple sclerosis, microglia are a key CNS cell population moving back and forth in a continuum of beneficial and deleterious states. On the one hand, they can contribute to neurorepair by clearing myelin debris, which is a prerequisite for remyelination and neuroprotection. On the other hand, they also participate in autoimmune inflammation and axonal degeneration by producing pro-inflammatory cytokines and molecules. In this study, we demonstrate that siponimod can modulate the microglial reaction to lipopolysaccharide-induced pro-inflammatory activation.     

设计和仿真无线局域网设备天线

对带有开关电路的2.4 GHz极化分集印刷天线进行电磁场及电磁场与电路协同仿真 通过采用极化分集技术,可以用低成本PCB基片制造具有良好接收机性能的无线局域网设备(WLAN)天线.本文将描述如何使用最新的三维电磁场(EM)仿真工具来设计和仿真一对2.4GHz正交极化的印刷偶极子天线,同时预测表面电流和相关的远场辐射图.     

An altruistic differentiated service protocol in dynamic cognitive radio networks against selfish behaviors

Cognitive Radio (CR), first proposed by Mitola, has the potential to improve spectrum utilization by allowing secondary transmission in licensed primary networks, as long as the secondary transmissions do not interfere with the operation of the primary users (PUs) in the primary network. Although it is fundamental to the viability of this burgeoning technology, security aspects of CR have so far received scant attention from researchers. Initial research on CR has largely focused on the issues of resource allocation, spectrum sensing and management while security considerations are often added as an afterthought. As a result, many proposed solutions for CR, have introduced significant security gaps, intensifying the effects of selfishness, inequity, unavailability, or even malicious behaviors. This has posed challenges to quality-of-service (QoS) provisioning in Cognitive Radio Network (CRN) in the face of various network attacks like node masquerading, packet mislabeling and deliberate packet dropping. Since existing routing protocols assume that nodes will forward packets in good faith, the presence of selfish nodes coupled with the dynamic behavior of PUs can lead to excessive packet losses, high delays or even the complete failure of routing protocols in secondary networks. In this paper, we propose a cross-layer Altruistic Differentiated Service Protocol (ADSP) for the dynamic CRNs to address the QoS provisioning issue in CRNs with selfish nodes coexistence. Simulation results demonstrate that the ADSP can achieve much better performance in terms of lower delay, higher throughput and better delivery ratio for the traffic originating from collaborative nodes compared to other cognitive routing protocols in the presence of selfish nodes.