Consistency requirements in business process modeling: a thorough overview

Software and Systems Modeling - The field of business process modeling has been beset by inter-model consistency problems which are mainly due to the existence of multiple variants of the same...     

Water Management in the Mediterranean Region: Concepts and Policies

The Mediterranean Region exhibits significant contrasts in its demographic and hydrologic features that have shaped the water management policies of the Mediterranean countries. Although awareness is raising with respect to sustainable water management, the extent to which it is applied in practice is debatable. Use conflicts and non-renewable water extraction in water scarce part of the region like the Southern and Eastern rim countries are exposed as overriding management issues. Furthermore climatic variations are superimposed on natural hydro-stress and water dependency on external resources in most of the cases. Decision-making process needs measurable, comparable and reliable tools in order to be able to make trade-offs when facing conflicting issues. Indicators are valuable tools for understanding the trends and challenges encountered in water resources management. The Contracting Parties to the Barcelona Convention adopted, in November 2005, the Mediterranean Strategy for Sustainable Development (MSSD). Integrated water resources and demand management constitute the first priority among the range of actions of the adopted strategy. Increasing efficiency by reducing losses and wasteful use is expected to help stabilise water demand in the Southern and Eastern part of the Mediterranean countries. In this paper, an assessment of the existing water management concepts and policies in Mediterranean countries will be presented based on sustainable development indicators related to water management.     

Effects of radiologists' skill and experience on patient doses in interventional examinations

In this study, effects of radiologists' skill and experience on patient doses were investigated. Dose-area product and entrance surface doses of two groups of patients, one examined by a number of junior radiologists and another one by a senior radiologist, have been compared for the diagnostic interventional examinations of cerebral and lower limbs. Collimation of the X-ray beam and shortening the fluoroscopy times by the senior radiologist considerably reduced the patient doses for interventional cerebral examinations.     

Simulation of hypersonic flows on unstructured grids

The paper describes a solver for the compressible inviscid flow equations which is based on a flux vector splitting strategy able to deal with chemical reaction effects. The methodology here adopted is based on a modification of the Flux Vector Splitting technique due to van Leer.¹¹ The scheme operates on completely unstructured grids and has been coupled with an adaptive remeshing procedure to compute high speed flows. Solutions for two-dimensional problems for non-reactive and reactive air in thermodynamic equilibrium are presented.     

n-6 High Fat Diet Induces Gut Microbiome Dysbiosis and Colonic Inflammation

Background: Concerns are emerging that a high-fat diet rich in n-6 PUFA (n-6HFD) may alter gut microbiome and increase the risk of intestinal disorders. Research is needed to model the relationships between consumption of an n-6HFD starting at weaning and development of gut dysbiosis and colonic inflammation in adulthood. We used a C57BL/6J mouse model to compare the effects of exposure to a typical American Western diet (WD) providing 58.4%, 27.8%, and 13.7% energy (%E) from carbohydrates, fat, and protein, respectively, with those of an isocaloric and isoproteic soybean oil-rich n-6HFD providing 50%E and 35.9%E from total fat and carbohydrates, respectively on gut inflammation and microbiome profile. Methods: At weaning, male offspring were assigned to either the WD or n-6HFD through 10–16 weeks of age. The WD included fat exclusively from palm oil whereas the n-6HFD contained fat exclusively from soybean oil. We recorded changes in body weight, cyclooxygenase-2 (COX-2) expression, colon histopathology, and gut microbiome profile. Results: Compared to the WD, the n-6HFD increased plasma levels of n-6 fatty acids; colonic expression of COX-2; and the number of colonic inflammatory and hyperplastic lesions. At 16 weeks of age, the n-6HFD caused a marked reduction in the gut presence of Firmicutes, Clostridia, and Lachnospiraceae, and induced growth of Bacteroidetes and Deferribacteraceae. At the species level, the n-6HFD sustains the gut growth of proinflammatory Mucispirillum schaedleri and Lactobacillus murinus. Conclusions: An n-6HFD consumed from weaning to adulthood induces a shift in gut bacterial profile associated with colonic inflammation.     

Formulation study of a patch containing propranolol by design of experiments

Objective: To evaluate the feasibility of a transdermal patch containing propranolol (PR).

Method: Skin penetration enhancers (SPEs) able to improve the skin permeability of PR were selected and a quality by design approach was applied to the development of the patch by a 2⁴ full factorial design. The permeation profile of PR from the formulations was assessed in in vitro permeation studies performed by using Franz diffusion cells and human epidermis as membrane. Finally, skin irritation was evaluated by the Draize test.

Results: N-methyl pyrrolidone (NMP) resulted as the best SPE: in addition, the critical factors influencing the PR diffusion through the human epidermis when loaded in the patch resulted in the matrix thickness (X₁, p?=?0.0957) and PR content (X₃, p?=?0.0004) which improved the flux; conversely, NMP lacked its enhancement effect when loaded in the patch and the increase in its concentration (X₄, p?=?0.006) affected the drug permeation through human epidermis. The flux of optimal formulation was 12.7?μg/cm²/h. On the basis of the steady-state concentration and clearance of PR, the estimated patch surface was 100–120 cm², since the activity of PR is related to its Senantiomer and no in vivo bioconversion occurs.

Conclusion: A patch containing (S)-PR was prepared and the (S)-PR flux (13.3?μg/cm²/h) permitted to confirm the suitability of a transdermal administration of PR. In particular, the use of a 50?μm thick methacrylic matrix containing 8% (S)-PR and 15% NMP can allow to develop a patch non-irritating to the skin, in order to ensure a constant permeation flux of PR over 48?h.     

Special section of BPMDS’2020 business process management meets data

Software and Systems Modeling -