Study of a BGO calorimeter using electron and hadron beams from 1 to 50 GeV

A calorimeter of 25 bismuth germanate (BGO) crystals equipped with silicon photodiode readout has been tested at the CERN SPS in the energy range 1–50 GeV. The response for electrons has been shown to be linear in this energy range and the rms resolution obtained ( ) is approximately 1%, for E > 4 GeV. The electron/pion separation was found to be better than 1:500 in the energy range 1–20 GeV. Data on lateral and longitudinal shower development were compared with the results of a Monte Carlo simulation using the SLAC-EGS program and found to be in good agreement.     

The beneficial effects of storage on the quality of wastewater for irrigation: a case study in Sicily.

Although the main function of reservoirs in agriculture is to allow the storage and temporal shifting of large volumes of waters, further benefits emerge from their application in wastewater reuse systems. In fact, as observed in several other studies carried out on such complex natural systems, the storage period, under proper conditions, can lead to a significant improvement of the water quality for irrigation thanks to concurrent physical, chemical and biological processes. In order to investigate the reservoir dynamics, an experimental research was carried out in a farm reservoir (volume of 11,000 m3, maximum depth of 6.3 m and mean depth of about 5 m), receiving treated wastewater and subject to scheduled highly variable input to volume ratios, in order to observe the broadest range of behaviour responses. Specifically, over a monitoring period lasted 4 months, the reservoir was operated as a standard batch reactor in the first and third phases and as a continuous flow reactor in the second one. Based on correlation analysis between the chemical, physical and biological water parameters and operational ones, a new operative index is proposed which integrates the morphological characteristics of the tank and the management ones, and shows a significant correlation with the qualitative characteristics of the stored water.     

A new method of magnetic resonance image reconstruction with short acquisition time and truncation artifact reduction

A method for the reconstruction of magnetic resonance images that allows for a substantial reduction of the quantity of measured data and, therefore, of the acquisition time is described. The truncation artifact is also reduced, improving the image quality. The method is based on techniques for getting superresolution in spectral analysis such as autoregressive modeling and Prony's method. Moreover, some new ideas about the autoregressive order selection are introduced. The method is compared to the standard one for reconstructing simulated, phantom, and medical magnetic resonance images. The numerical stability and the computational cost issues of the resulting algorithm are also addressed     

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which promote the formation of pathological hallmarks. A high-fat diet (HFD) is known to foster metabolic dysregulation and insulin resistance in the brain and such effects have been associated with the reduction of cognitive performances. Remarkably, a significant role in HFD-related cognitive decline might be played by aberrant protein O-GlcNAcylation by triggering the development of AD signature and mitochondrial impairment. Our data support the impairment of total protein O-GlcNAcylation profile both in the brain of mice subjected to a 6-week high-fat-diet (HFD) and in our in vitro transposition on SH-SY5Y cells. The reduction of protein O-GlcNAcylation was associated with the development of insulin resistance, induced by overfeeding (i.e., defective insulin signaling and reduced mitochondrial activity), which promoted the dysregulation of the hexosamine biosynthetic pathway (HBP) flux, through the AMPK-driven reduction of GFAT1 activation. Further, we observed that a HFD induced the selective impairment of O-GlcNAcylated-tau and of O-GlcNAcylated-Complex I subunit NDUFB8, thus resulting in tau toxicity and reduced respiratory chain functionality respectively, highlighting the involvement of this posttranslational modification in the neurodegenerative process.     

A METHOD FOR GENERATING INDEPENDENT REALIZATIONS OF A MULTIVARIATE NORMAL STATIONARY AND INVERTIBLE ARMA(p, q) PROCESS

Abstract. A method for generating finite independent realizations of a normal multivariate stationary ARMA( p, q ) process is proposed. It is based on an AR (1) representation of an ARMA( p, q ) process allowing for an exact generation of the initial values of the simulation algorithm. Input facilities are supplied in order to assure stationarity and invertibility of the considered process.     

Enhancing thermal and dynamic-mechanical properties of epoxy reinforced by amino-functionalized microcrystalline cellulose

In this study, microcrystalline cellulose (MCC) was chemically modified with 3-(aminopropyl)triethoxysilane and added to epoxy to improve chemical, thermal and dynamic-mechanical characteristics of the composites. The composites were manufactured aided by sonication with 1.0%, 2.5%, or 5.0% wt/wt of untreated MCC or amino-functionalized MCC (MCC-Si). The epoxy/MCC-Si composites showed a decrease in the ─OH band by Fourier-transform infrared spectroscopy, and X-ray diffraction analysis indicated better dispersion. The incorporation of MCC-Si in epoxy resin decreased the heat of reaction, increased activation energy values (E_a) and pre-exponential factor (A), and did not affect thermal degradation. All conversion degree (α) versus temperature curves for the composites showed a sigmoidal shape. MCC-Si composites showed better dynamic-mechanical properties than the MCC counterparts, and the functionalization effect was evidenced in storage modulus (E') and loss modulus (E"). At 2.5% wt/wt of MCC-Si content an increase of 119% in E' at the glassy region, 127% in E' at the rubbery region and 173% in E" was observed compared to the neat resin, whereas the T_g barely changed among samples. Good adhesion between the amino-functionalized MCC and the epoxy matrix was observed at the fracture surface, evidencing that surface modification of MCC improves their chemical interaction.     

Real-time digital control of optical interferometers by the mechanical-modulation technique

We discuss the application of digital systems to the automatic control of dual-wave optical interferometers. We show that, if the mechanical-modulation technique is used for error-signal extraction, digital techniques can be used both for error-signal extraction and for control-signal generation. Therefore, apart from two front/end amplifiers that are necessary to match the dynamics of the detectors and actuators to the dynamics of the analog-to-digital converters and digital-to-analog converters, no other analog devices are required. In particular, the mechanical-modulation technique requires the synchronous demodulation of the photodiode output signal. Hence we need to implement a digital lock-in amplifier whose algorithm is described here. Finally, we describe one of the possible applications of this digital control procedure, such as the control of a classic Mach-Zehnder interferometer in air.     

Convertibility of Function Points into COSMIC Function Points: A study using Piecewise Linear Regression

Background

COSMIC Function Points and traditional Function Points (i.e., IFPUG Function Points and more recent variation of Function Points, such as NESMA and FISMA) are probably the best known and most widely used Functional Size Measurement methods. The relationship between the two kinds of Function Points still needs to be investigated. If traditional Function Points could be accurately converted into COSMIC Function Points and vice versa, then, by measuring one kind of Function Points, one would be able to obtain the other kind of Function Points, and one might measure one or the other kind interchangeably. Several studies have been performed to evaluate whether a correlation or a conversion function between the two measures exists. Specifically, it has been suggested that the relationship between traditional Function Points and COSMIC Function Points may not be linear, i.e., the value of COSMIC Function Points seems to increase more than proportionally to an increase of traditional Function Points.

Objective

This paper aims at verifying this hypothesis using available datasets that collect both FP and CFP size measures.

Method

Rigorous statistical analysis techniques are used, specifically Piecewise Linear Regression, whose applicability conditions are systematically checked. The Piecewise Linear Regression curve is a series of interconnected segments. In this paper, we focused on Piecewise Linear Regression curves composed of two segments. We also used Linear and Parabolic Regressions, to check if and to what extent Piecewise Linear Regression may provide an advantage over other regression techniques. We used two categories of regression techniques: Ordinary Least Squares regression is based on the usual minimization of the sum of squares of the residuals, or, equivalently, on the minimization of the average squared residual; Least Median of Squares regression is a robust regression technique that is based on the minimization of the median squared residual. Using a robust regression technique helps filter out the excessive influence of outliers.

Results

It appears that the analysis of the relationship between traditional Function Points and COSMIC Function Points based on the aforementioned data analysis techniques yields valid significant models. However, different results for the various available datasets are achieved. In practice, we obtained statistically valid linear, piecewise linear, and non-linear conversion formulas for several datasets. In general, none of these is better than the others in a statistically significant manner.

Conclusions

Practitioners interested in the conversion of FP measures into CFP (or vice versa) cannot just pick a conversion model and be sure that it will yield the best results. All the regression models we tested provide good results with some datasets. In practice, all the models described in the paper - in particular, both linear and non-linear ones - should be evaluated in order to identify the ones that are best suited for the specific dataset at hand.     

A comprehensive solution for application‐level adaptation

Driven by the emergence of mobile and pervasive computing there is a growing demand for context‐aware software systems that can dynamically adapt to their run‐time environment. We present the results of project MADAM that has delivered a comprehensive solution for the development and operation of context‐aware, self‐adaptive applications. The main contributions of MADAM are (a) a sophisticated middleware that supports the dynamic adaptation of component‐based applications, and (b) an innovative model‐driven development methodology that is based on abstract adaptation models and corresponding model‐to‐code transformations. MADAM has demonstrated the viability of a general, integrated approach to application‐level adaptation. We discuss our experiences with two real‐world case studies that were built using the MADAM approach. Copyright © 2008 John Wiley & Sons, Ltd.