This paper investigates the effects of processing and equipment parameters of a ribbon blender (i.e. loading method of lubricant, fill level, blade speed and blade design) on magnesium stearate homogeneity. A core sampling technique is used to obtain at least one hundred samples per sampling event, which are extracted throughout the blender and yield a thorough characterization of the entire bed. The results presented here can be used as a guideline to develop appropriate blending processes and characterization protocols for ribbon blenders. 相似文献
The objective of this study was to investigate the ability of E. coli in river sediments to degrade estrogen conjugates. Biodegradation experiments on glucuronide estrogens (E1-GLU, E2-GLU and E3-GLU) using E. coli, non-E. coli bacteria as well as sediment crude extracts were carried out in batch mode. A pure identified E. coli strain (KCTC 2571) was used for comparison of enzyme activity. The results showed that the degradation rate of estrogen conjugates by KCTC 2571 and E. coli isolated from sediments followed a similar trend. Fecal bacteria showed a high ability to deconjugate glucuronided estrogens. Approximately 50% of glucuronide moieties were cleaved within 4 h of contact time in experiments using pure E. coli. The degradation rate was slower in experiments using crude extracts of sediments, and conjugated estrogens were not completely degraded even after 12 h of reaction. These results provide a clear understanding of the fate and behavior of estrogen by bacteria in the environment. 相似文献
Organizations are increasingly delegating customer inquiries to speech dialog systems (SDSs) to save personnel resources. However, customers often report frustration when interacting with SDSs due to poorly designed solutions. Despite these issues, design knowledge for SDSs in customer service remains elusive. To address this research gap, we employ the design science approach and devise a design theory for SDSs in customer service. The design theory, including 14 requirements and five design principles, draws on the principles of dialog theory and undergoes validation in three iterations using five hypotheses. A summative evaluation comprising a two-phase experiment with 205 participants yields positive results regarding the user experience of the artifact. This study contributes to design knowledge for SDSs in customer service and supports practitioners striving to implement similar systems in their organizations.
This paper is concerned with the robust control problem of linear fractional representation (LFT) uncertain systems depending on a time-varying parameter uncertainty. Our main result exploits a linear matrix inequality (LMI) characterization involving scalings and Lyapunov variables subject to an additional essentially nonconvex algebraic constraint. The nonconvexity enters the problem in the form of a rank deficiency condition or matrix inverse relation on the scalings only. It is shown that such problems, but also more generally rank inequalities and bilinear constraints, can be formulated as the minimization of a concave functional subject to LMI constraints. First of all, a local Frank and Wolfe (1956) feasible direction algorithm is introduced in this context to tackle this hard optimization problem. Exploiting the attractive concavity structure of the problem, several efficient global concave programming methods are then introduced and combined with the local feasible direction method to secure and certify global optimality of the solutions. Computational experiments indicate the viability of our algorithms, and in the worst case, they require the solution of a few LMI programs 相似文献
Lecontite, (NH4)Na(SO4).2H2O, was synthesised at room temperature in high purity compared to earlier work with a minor impurity of mascagnite, (NH4)2SO4. Rietveld refinement of the XRD results confirmed the crystal structure and unit cell dimensions as published earlier. Raman
and Infrared spectroscopy, in conjunction with factor group analysis, resulted in a complex pattern of overlapping sulphate,
NH and OH modes. The NH modes υ1 was observed around 2880 cm−1, υ2 around 1700 cm−1 overlapping with water OH-bending modes, υ3 around 3300 cm−1 overlapping with water OH-stretching modes around 3023, 3185 and 3422 cm−1, and υ4 around 1432, 1447 and 1462 cm−1. The sulphate group in the crystal structure displays a decrease in symmetry from Td as evidenced by the activation of the ν1 mode at 982 cm−1 and the ν2 mode around 452 cm−1 in the Infrared spectrum. The υ3 mode shows clear splitting in the infrared spectra with a strong band at 1064 cm−1 accompanied by two shoulders at 1107 and 1139 cm−1. The Raman spectra show three weak bands at 1068, 1109 and 1135 cm−1 with a shoulder at 1155 cm−1. Similar splitting was observed for the υ4 mode around 611 and 632 cm−1 in the Infrared and Raman spectra, respectively. 相似文献
TBI induces splenic B and T cell expansion that contributes to neuroinflammation and neurodegeneration. The vagus nerve, the longest of the cranial nerves, is the predominant parasympathetic pathway allowing the central nervous system (CNS) control over peripheral organs, including regulation of inflammatory responses. One way this is accomplished is by vagus innervation of the celiac ganglion, from which the splenic nerve innervates the spleen. This splenic innervation enables modulation of the splenic immune response, including splenocyte selection, activation, and downstream signaling. Considering that the left and right vagus nerves have distinct courses, it is possible that they differentially influence the splenic immune response following a CNS injury. To test this possibility, immune cell subsets were profiled and quantified following either a left or a right unilateral vagotomy. Both unilateral vagotomies caused similar effects with respect to the percentage of B cells and in the decreased percentage of macrophages and T cells following vagotomy. We next tested the hypothesis that a left unilateral vagotomy would modulate the splenic immune response to a traumatic brain injury (TBI). Mice received a left cervical vagotomy or a sham vagotomy 3 days prior to a fluid percussion injury (FPI), a well-characterized mouse model of TBI that consistently elicits an immune and neuroimmune response. Flow cytometric analysis showed that vagotomy prior to FPI resulted in fewer CLIP+ B cells, and CD4+, CD25+, and CD8+ T cells. Vagotomy followed by FPI also resulted in an altered distribution of CD11bhigh and CD11blow macrophages. Thus, transduction of immune signals from the CNS to the periphery via the vagus nerve can be targeted to modulate the immune response following TBI. 相似文献
Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this pharmacomodulation and obtained nanomolar active molecules (EC50) against this pathogen. This gain in activity prompted us to evaluate the antibacterial activity of this family of molecules against other pathogenic bacteria, such as Neisseria gonorrhoeae and bacteria from the ESKAPE group. The results show that the novel molecules have selectively improved activity against C. trachomatis and demonstrate how the antichlamydial effect of fluoroquinolones can be enhanced. 相似文献
The objective of this study was to examine the potential of stress wave velocity (SWV) as a rapid and non-destructive method to estimate the mechanical properties of Melia azedarach wood. The SWV, dynamic modulus of elasticity (MOEd), modulus of elasticity (MOE), modulus of rupture (MOR, bending strength) and density were determined on ninety 20 ? 20 ? 320 mm clear wood specimens, obtained from stems of three ten-year-old M. azedarach trees, and tested at environmental equilibrium in 20°C, 60?% relative humidity (a moisture content of approximately 12?%). There was a statistically significant (0.1?% level) but weak correlation (R2?=?0.23) between the SWV and MOE, but no statistically significant correlation was found between the SWV and MOR. Much better results for prediction of static properties of M. azedarach wood were obtained when SWV and wood density (WD) were used together through calculation of MOEd in the air-dry condition (MOE: R2?=?0.76, MOR: R2?=?0.47), although in the case of MOR a model based on WD alone is slightly better (R2?=?0.58), and WD is also almost as good as MOEd for predicting MOE. It is concluded that SWV coupled with WD can be employed as a predicting parameter to evaluate the mechanical properties of M. azedarach wood during the manufacturing process, although WD alone is also effective. The SWV alone would not be useful due to MOE being almost directly proportional to WD at this moisture content.