Variability in rheology of cemented paste backfill with hydration age,binder and superplasticizer dosages

The use of (CPB) material to ameliorate geotechnical stability of underground mine is in nascent stage in India. Rheological properties of CPB change with travelling time as it is transported to underground mine stope through pipeline reticulation. In this paper, rheological properties of CPB based on mill tailings of a carbonate rich mineral processing waste are evaluated for different dosages of polycarboxylate (PC) based (SP). Each CPB sample having 78?wt% solids is mixed separately with 4%, 6% or 8% of binder dosages (ratio of the weight of dry binder to the weight of dry tailings) and, 0%, 0.5%, or 1.0% of SP dosages as weight of dry binder. The paper presents a methodology for determining yield stress, plastic viscosity and thixotropic behaviour of CPB mixture as a function of hydration age, binder and SP dosages. Results from the experimental campaigns indicate that SP content has significant influence on rheological behaviour of CPB and can be suitably exploited to enhance the flow characteristics of the carbonate rich process tailings. The study also develops multivariate linear regression models of yield stress, plastic viscosity and thixotropy of CPB depending on the hydration age, binder and SP dosages.     

Experimental investigation on the effect of MgO and TiO2 nanoparticles in stepped solar still

This work aims at augmenting the amount of potable water using MgO and TiO₂ in stepped solar still. Experiments were carried out for the climatic conditions of Chennai, India, with two different concentrations of nanofluids inside a stepped basin under three different cases. Results show that there is an improvement in yield of fresh water from stepped solar still by 33.18% and 41.05% using 0.1% and 0.2% volume concentration of TiO₂ nanofluid, respectively, whereas the freshwater yield from stepped still with MgO nanofluids improved by 51.7% and 61.89%. Furthermore, the economic analysis revealed that the cost of potable water from the modified solar still reduced from 0.029 to 0.016 $/kg. Similarly, the useful annual energy, yearly cost per kilogram, and annual cost per kilowatt hour are significantly profitable with the use of MgO nanofluid in the stepped basin and found as 512.46 kWh, 0.025 $/kg, and 0.026 $/kWh, respectively. It is also found that the cost of potable water from the modified still significantly increases as the amount of fresh water produced is decreased with increased fabrication cost of the solar still.     

Validation of the Applied Biosystems Prism 377 automated sequencer for the forensic short tandem repeat analysis

The Applied Biosystems (ABI) Prism 377 DNA sequencer has been evaluated in an attempt to increase the throughput of samples for short tandem repeat (STR) analysis, in both forensic casework and the UK National Criminal Intelligence DNA Database. The gel system assessed consisted of 0.2 mm, 4% acrylamide 6 M urea gels, with a well-to-read distance of 36 cm. Gels were run at a constant voltage of 3 kV and constant temperature of 51 degrees C. The run time of our second generation multiplex (SGM) STR system was achieved in less than 2 h. Rigorous validation has been performed on the instrument hardware and software. Complete resolution of 1 base differences was obtained, up to and beyond 350 bases; sizing precision across gels was more than 2-fold higher than the 373A and the sensitivity was increased by one third.     

The Significance of multicomponent diffusional interactions in the process of condensation in the presence of a non condensable gas

Recent developments in the understanding of multicomponent heat and mass transfer have indicated that the so called “diffusional interaction effects” might be important in Engineering Design under certain conditions. It is shown that the significance of these multicomponent effects may be readily diagnosed in a given situation. By considering mixtures of various alkanes with nitrogen and hydrogen, it is shown that large “diffusional interaction ettects” are unlikely in condensation of two vapours in the presence of a non condcnsable gas.     

Unknown input observer design and analysis for networked control systems

The insertion of communication networks in the feedback loops of control systems is a defining feature of modern control systems. These systems are often subject to unknown inputs in a form of disturbances, perturbations, or attacks. The objective of this paper is to design and analyse an observer for networked dynamical systems with unknown inputs. The network effect can be viewed as either a perturbation or time-delay to the exchanged signals. In this paper, we (1) review an unknown input observer (UIO) design for a non-networked system, (2) derive the networked unknown input observer (N_etUIO) dynamics, (3) design a N_etUIO such that the effect of higher delay order terms are nullified and (4) establish stability-guaranteeing bounds on the networked-induced time-delay and perturbation. The formulation and results derived in this paper can be generalised to scenarios and applications where the signals are perturbed due to a different source of perturbation or delay.     

Fragment-Based Drug Discovery for RNA Targets

Rapid development within the fields of both fragment-based drug discovery (FBDD) and medicinal targeting of RNA provides possibilities for combining technologies and methods in novel ways. This review provides an overview of fragment-based screening (FBS) against RNA targets, including a discussion of the most recently used screening and hit validation methods such as NMR spectroscopy, X-ray crystallography, and virtual screening methods. A discussion of fragment library design based on research from small-molecule RNA binders provides an overview on both the currently limited guidelines within RNA-targeting fragment library design, and future possibilities. Finally, future perspectives are provided on screening and hit validation methods not yet used in combination with both fragment screening and RNA targets.     

Variable friction pendulum system for seismic isolation of liquid storage tanks

Earthquake response of liquid storage steel tanks isolated with variable friction pendulum system (VFPS) is investigated under normal component of six recorded near-fault ground motions. The continuous liquid mass of the tank is modeled as lumped masses known as sloshing mass, impulsive mass and rigid mass. The corresponding stiffness constants associated with these lumped masses are worked out depending upon the properties of the tank wall and liquid mass. The governing equations of motion of the tanks isolated with variable friction pendulum system are derived and solved by Newmark's step-by-step method assuming linear variation of acceleration over small time interval. In order to verify the effectiveness of the VFPS in tanks, the seismic response of tanks isolated with VFPS is compared with that of the same tanks isolated using the conventional friction pendulum system (FPS). Furthermore, a parametric study is also carried out to critically examine the behaviour of tanks isolated with VFPS. The various important parameters considered are the tank aspect ratio, the isolation period and initial time period of the VFPS. In addition, the seismic response of tanks isolated with VFPS under trigonometric cycloidal pulses is also investigated. From these investigations, it is concluded that with the installation of VFPS in tanks, the seismic response of tanks during near-fault ground motions can be controlled within a desirable range. Finally, it is also observed that the response of tanks isolated with VFPS under the near-fault ground motions and trigonometric cycloidal pulses matches well only when the isolation period reaches high values.     

Performance analysis of evacuated tubes coupled solar still with double basin solar still and solid fins

ABSTRACT

Experimental set up of double basin solar still with evacuated tubes has been fabricated by locally available materials and then carry out research work by use of solid fins. Here 2.5?cm constant depth of water maintained and 3?cm depth mild steel fins are used. Experimental results have been obtained during month of March and April 2018 during clear sky days. Month of March 2018 is chosen for experiments on double basin solar still with evacuated tubes only and April 2018 is chosen for experiments on double basin solar still with evacuated tubes and fins. After series of experiments, it has been found that, the fins increase 25% distillate output compared with alone double basin solar still with evacuated tubes. It also increases distillate output during sunshine hours as well as off-sunshine hours.