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1.
MA Nowak AL Lloyd GM Vasquez TA Wiltrout LM Wahl N Bischofberger J Williams A Kinter AS Fauci VM Hirsch JD Lifson 《Canadian Metallurgical Quarterly》1997,71(10):7518-7525
Mathematical modeling of viral replication dynamics, based on sequential measurements of levels of virion-associated RNA in plasma during antiretroviral treatment, has led to fundamental new insights into human immunodeficiency virus type 1 pathogenesis. We took advantage of the simian immunodeficiency virus (SIV)-infected macaque model to perform detailed measurements and mathematical modeling during primary infection and during treatment of established infection with the antiretroviral drug (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA). The calculated clearance half-life for productively infected cells during resolution of the peak viremia of primary infection was on the order of 1 day, with slightly shorter clearance half-lives calculated during PMPA treatment. Viral reproduction rates upon discontinuation of PMPA treatment after 2 weeks were approximately twofold greater than those obtained just prior to initiation of treatment in the same animals, likely reflecting accumulation of susceptible target cells during treatment. The basic reproductive ratio (R0) for the spread of SIV infection in vivo, which represents the number of productively infected cells derived from each productively infected cell at the beginning of infection, was also estimated. This parameter quantifies the extent to which antiviral therapy or vaccination must limit the initial spread of virus to prevent establishment of chronic disseminated infection. The results thus provide an important guide for efforts to develop vaccines against SIV and, by extension, human immunodeficiency virus. 相似文献
2.
Nicolas Clauvelin Basile Audoly Sébastien Neukirch 《Scientific Modeling and Simulation》2007,14(1):95-101
The DNA molecule is modeled as an elastic rod with bending and twisting rigidities, subjected to external tension and twist applied at one end, the other end being clamped. We study the plectonemic equilibrium of such a rod, taking into account the impenetrability constraint. Numerical solutions of this boundary value problem have previously shown that purely elastic models can reproduce the supercoiling response of the DNA molecule. Using a variational approach, we derive analytical formulae for the elastic response of the filament, and extend former numerical results. 相似文献
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Location and calculation-free node-scheduling schemes in large wireless sensor networks 总被引:1,自引:0,他引:1
In wireless sensor networks that consist of a large number of low-power, short-lived, unreliable sensors, one of the main design challenges is to obtain long system lifetime without sacrificing system original performance (sensing coverage and sensing reliability). To solve this problem, one of the potential approaches is to identify redundant nodes at the sensing interface and then assign them an off-duty operation mode that has lower energy consumption than the normal on-duty mode. In our previous work [J. Wireless Commun. Mobile Comput. 3 (2003) 271; Processing of ACM Wireless Sensor Network and Application Workshop 2002, September 2002], we proposed a node-scheduling scheme, which can provide a 100% sensing coverage preservation capability. This, however, requires each node to be aware of its own and its neighbors’ location information. Also, in that scheme, each node has to do accurate geometrical calculation to determine whether to take an off-duty status. In this paper, we propose and study several alternative node-scheduling schemes, which cannot completely preserve the original system coverage, but are nonetheless light-weighted and flexible compared with the previous one. Our simulation results compare these schemes with the previous one and demonstrate their effectiveness. 相似文献
5.
This article is based on experiences with data and text mining to gain information for strategic business decisions, using host-based analysis and visualisation (A/V), primarily in the field of patents. The potential advantages of host-based A/V are pointed out and the features of the first such A/V software, STN®AnaVist™, are described in detail. Areas covered include the user interfaces, initial set of documents for A/V, data mining, text mining, reporting, and suggestions for further development. 相似文献
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C sar Ovalles Carlos Vallejos Tito Vasquez Iraima Rojas Ursula Ehrman Jose Luis Benitez Ronald Martinez 《Petroleum Science and Technology》2003,21(1):255-274
An extra-heavy crude oil underground upgrading process is described which involves the downhole addition of a hydrogen donor additive under steam injection conditions (280-315°C and residence times of at least 24-h). Laboratory experiments showed a 4° increase in the API gravity (from 9 to 12°) of the upgraded product, a two-fold reduction in the viscosity and, an approximately 8% decrease in the asphaltene content with respect to the original crude. Further increases on the temperature led to products with improved properties reaching 15°API at 315°C. It was found that the presence of the natural formation (catalysts) and methane (natural gas) is necessary to enhance the properties of the upgraded crude oil. From GC and GC-MS results a reaction pathway is proposed that involves hydrogen transfers from tetralin to the extra-heavy crude oil resulting in the formation of 1,2-dihydronaphthalene. This compound is then transformed into naphthalene, further upgrading of crude oil through hydrogen donation. The results of the experiments carried out in the presence and absence of the mineral formation and with an inert solid (SiC) strongly indicate that the former acts as a catalyst and not as a heat transfer matrix. Isotopic labeling studies (CD4 and 13CH4) give evidences that, most probably, methane is involved in the upgrading reactions. 相似文献
8.
Peridynamic modeling of concrete structures 总被引:3,自引:0,他引:3
Walter Gerstle Nicolas Sau Stewart Silling 《Nuclear Engineering and Design》2007,237(12-13):1250-1258
The peridynamic model described in Silling (Silling, S.A., 1998. Reformation of Elasticity Theory for Discontinuous and Long-Range Forces, SAND98-2176. Sandia National Laboratories, Albuquerque, NM), being a central-force model, is limited to modeling materials with a Poisson's ratio of 1/4. In this paper, the peridynamic model is generalized by adding pairwise peridynamic moments to simulate linear elastic materials with varying Poisson's ratios. The new model is called the “micropolar peridynamic model”. The micropolar peridynamic model is placed within a finite element context to enable efficacious application of boundary conditions and efficient computational solutions using an implicit, rather than an explicit solution algorithm. The implicit solution algorithm is suitable for quasistatic simulation of damage and cracking in concrete structures. With this new model, very simple tensile damage mechanisms at the micro structural (peridynamic) level are sufficient to explain a great deal of the microcracking (damage) and fracture mechanics observed in concrete structures. The new implementation appears to be computationally efficient. 相似文献
9.
Guimond Serge; Dambrun Micha?l; Michinov Nicolas; Duarte Sandra 《Canadian Metallurgical Quarterly》2003,84(4):697
Social dominance orientation (SDO) has been proposed as an important variable in the explanation of prejudice. We distinguish between three conceptualizations of SDO: SDO as a personality trait (personality model), SDO as a moderator of the effects of situational variables (Person X Situation model), and SDO as a mediator of the effect of social position on prejudice (group socialization model [GSM]). Four studies (N = 1,657) looking at the relations between social positions, SDO, and prejudice in a natural setting and in a laboratory setting provide strong support for the GSM. In contrast to previous correlational findings, there is evidence of a cause (dominant social position), an effect (prejudice increases), and a mediator (SDO). These results suggest new perspectives on the integration of individual and contextual determinants of prejudice. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
This paper analyses the technical efficiency in the hydroelectric generating plants of a main Portuguese electricity enterprise EDP (Electricity of Portugal) between 1994 and 2004, investigating the role played by increase in competition and regulation. A random cost frontier method is adopted. A translog frontier model is used and the maximum likelihood estimation technique is employed to estimate the empirical model. We estimate the efficiency scores and decompose the exogenous variables into homogeneous and heterogeneous. It is concluded that production and capacity are heterogeneous, signifying that the hydroelectric generating plants are very distinct and therefore any energy policy should take into account this heterogeneity. It is also concluded that competition, rather than regulation, plays the key role in increasing hydroelectric plant efficiency. 相似文献