Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro

Negatively charged fluorescent carbon dots (CDs, E_m=608 nm) were hydrothermally prepared from thiophene phenylpropionic acid polymers and then successfully loaded with the positively charged anticancer cargo coptisine, which suffers from poor bioavailability. The formed CD-coptisine complexes were thoroughly characterized by particle size, morphology, drug loading efficiency, drug release, cellular uptake and cellular toxicity in vitro and antitumor activities in vivo. In this nano-carrier system, red emissive CDs possess multiple advantages as follows: 1) high drug loading efficiency (>96 %); 2) sustained drug release; 3) enhanced drug efficacy towards cancer cells; 4) EPR effect; 5) drug release tracing with near-infrared imaging. These properties indicated that red emissive CDs prepared from polymers could be used as a novel drug delivery system with integrated therapeutic and imaging functions in cancer therapy, which are expected to have great potential in future clinical applications.     

蔬果磷稳定性研究

用非离子型表面活性剂和吡咯类化合物作稳定剂，加入由约含８０％蔬果磷原药配制的２５％乳油中，制剂被装入安瓿瓶内，在５４℃条件下，储存１４天。分析蔬果磷的含量，没有加稳定剂的，蔬果磷仅残留约５３．４４％，加入稳定剂的，蔬果磷含量至少存在９６．２９％。然而当蔬果磷２５％乳油用３５％左右的原药和稳定剂配制时，在上述储存条件下蔬果磷的分解率为４５％－７０％。     

可导通非电起爆系统研究

阐述采用非电导爆管组装成全封闭系统，以实现网路导通检查，并有效控制瓦斯引爆。     

考虑管冷的大体积混凝土水化热分析

目的研究管冷的设计方法和控制措施,从而减小混凝土内部温度梯度,控制混凝土温度裂缝.方法采用混凝土内部布置冷水管,研究管径、进水温度、水流量和通水时间等因素对大体积混凝土水化热现象的影响,以确定对应参数合理范围.结果分析得到在管冷直径为20 mm、进水温度15℃、水流量为1.5 m3/h时,承台的冷却效果较好并达到要求.结论通过合理的管冷设计,能够起到良好的降温效果并且减少资源浪费.在大体积混凝土温度控制中要尽量控制好各个影响因素的相互关系.     

EFFECT OF LASER SCANNING SPEED ON PHASE CONSTITUTION AND WEAR RESISTANCE OF LASER CLADDING HARD FACING ALLOY STELLITE 12

Effect of laser scanning speed on phase constitution,microstructure,microhardness and wearresistance of laser-cladding hard facing alloy Stellite 12 has been investigated by means of across-flow-type CO_2 laser of 1.5 kW.The laser-cladding layer on the alloy consists of ma-trix phase of suppersaturated solid solution γ(Co,Cr)and complex hexagonal carbideM_7C_3.Under certain condition,at higher laser scanning speed,the suppersaturated solubilityof elements increases in γ(Co,Cr),and the precipitation of the complex carbtde M_7C_3 de-creases,so the microhardness increases and the wear resistance decreases.But at slower laserscanning speed,more complex carbide M_7C_3 may precipitate,and the wear resistance may beimproved.Therefore,it is believed that the principal factor in improving wear resistance is theprecipitation of carbide M_7C_3,while increment of microhardness is the suppersaturated solu-bility of elements in matrix phase γ(Co,Cr).     

Data Fusion-based resilient control system under DoS attacks: A game theoretic approach

In this paper, the resilient control under the Denial-of-Service (DoS) attack is rebuilt within the framework of Joint Directors of Laboratories (JDL) data fusion model. The JDL data fusion process is characterized by the so-called Game-in-Game approach, where decisions are made at different layers. The interactions between different JDL levels are considered which take the form of Packet Delivery Rate of the communication channel. Some criterions to judge whether the cyber defense system is able to protect the underlying control system is provided. Finally, a numerical example is proposed to verify the validity of the proposed method.     

水库水中有机物特性对生成消毒副产物的影响

饮用水中消毒副产物( DBPs)对人体健康构成极大威胁,明确水源水中有机物的特性及对DBPs生成的影响,是实现DBPs有效源头控制的关键环节.研究探讨了上海某水库水源水中有机物不同组分与消毒副产物生成潜能之间的关系,为水处理工艺及饮用水安全保障技术研究提供基础性数据.结果表明,水样中亲水性有机物比例占到60％左右;各组分的相对分子质量分布情况以小于1 000的小分子为主;加强消毒前水处理工艺对亲水性和小分子有机物的去除,可以有效控制DBPs的生成.     

基于TMS320F2812的液晶显示模块接口设计

为适应工业应用现场以及智能化仪器仪表前端显示的需要,阐述了TMS320F2812DSP和QH2001液晶显示模块的原理及特性,提出了一种基于高速DSP处理器控制低速液晶显示模块的接口设计方案,并对该方案的硬件接口电路和软件驱动程序进行了设计,同时给出了软、硬件实现的相应电路图、程序流程图以及具体程序段;实验调试表明,设计方案结构简单、成本低、抗干扰能力强、显示性能稳定可靠,达到设计要求,能够有效解决高速DSP对低速LCD的驱动及显示问题,并取得了良好的显示效果,对其它便携式系统显示终端的设计也具有一定参考价值。     

基于积分宽度法测量发光二极管结温方法的研究

本文提出了一种基于光谱积分宽度法来测量发光二极管(light emitting diode, LED)结温的新方法,并进行了理论分析和实验研究。本方法主要分为光谱数据采集、定标函数的测定和结温测量三个过程。首先,为了测量成本的降低和精度的提高而采用在正常工作电流下采集LED光谱数据,并通过采用不同温度下的光谱积分宽度与选定的某一基准状态下的值逐差可得到线性度达0.99以上的定标函数,并通过此定标函数可实时测定任意状态下的结温。其次,为了比较本方法测量结温的精确性,分别对单色和白光LED采用本方法和业界主流的正向电压法,通过自行设计的基于积分宽度法结温测量系统和美国Mentor Graphics公司的T3Ster型仪器的测量结果进行比较,两种方法测出的结温最大偏差为2.1℃,在可接受的误差范围内。实验结果表明积分宽度法测结温具有高效便捷且低成本的的特点,具有一定的应用前景。