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1.
D Brown S Kogan E Lagasse I Weissman M Alcalay PG Pelicci S Atwater JM Bishop 《Canadian Metallurgical Quarterly》1997,94(6):2551-2556
The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (PML) with the retinoic acid receptor alpha gene (RAR alpha). To test the hypothesis that the chimera PMLRAR alpha plays a role in leukemogenesis, we expressed a PMLRAR alpha cDNA in myeloid cells of transgenic mice. PMLRAR alpha transgenic mice exhibited impaired neutrophil maturation early in life, which progressed at a low frequency over the course of several months to overt APL. Both the preleukemic state and the leukemia could be transplanted to nontransgenic mice, and the transplanted preleukemia could progress to APL. The APL recapitulated features of the human disease, including a response to retinoic acid. Retinoic acid caused the leukemic cells to differentiate in vitro and in vivo, eliciting remissions of both the preleukemic state and APL in mice. Our results demonstrate that PMLRAR alpha impairs neutrophil differentiation and initiates the development of APL. The transgenic mice described here provide an apparently accurate model for human APL that includes clear evidence of tumor progression. The model should be useful for exploring the molecular pathogenesis of APL and the mechanisms of the therapeutic response to retinoic acid, as well as for preclinical studies of therapeutic regimens. 相似文献
2.
This article presents and evaluates the performance of a location sensing algorithm developed and demonstrated at Carnegie Mellon University. We compare our model with various others based on different architectures and software paradigms. We show comparative results in accuracy, the complexity of training, total power consumption, and suitability to users. Our method reduces training complexity by a factor of eight over previous algorithms, and yields noticeably better accuracy. The algorithm uses less power than previous models, and offers a more secure privacy model. 相似文献
3.
Rudolf Felix 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2008,12(2):129-135
Real world applications of a decision model of relationships between goals based on fuzzy relations are presented. In contrast
to other approaches the relationships between decision goals or criteria for each decision situation are represented and calculated
explicitly. The application fields are decision making for financial services and optimization of production sequences in
car manufacturing. 相似文献
4.
Necessary and sufficient conditions for robust stability of a family of polynomials with complex coefficients are provided. This work generalizes a frequency-domain criteria for robust stability of continuous linear systems reported on by Y.Z. Tsypkin and B.T. Polyak (1991) 相似文献
5.
An optimal control approach to continuous-time aggregate production planning problems is presented. The proposed approach describes the production and capacity evolution (expansion, sell and deterioration) processes in the form of differential equations with regular production, subcontracting and capacity change rates controllable on one hierarchical level. In this way, the traditional disadvantages of the two-level problem consideration (one level for strategic capacity planning and the other for production smoothing) are avoided. Analytical properties for optimal production and capacity control regimes and conditions for their changeover are derived by the maximum principle. Based on these results, an insight into the optimal behaviour of the production system is gained and a fast numerical method is developed to identify and sequence the optimal regimes for arbitrary demand profiles. A computational example illustrates the effectiveness of the approach. 相似文献
6.
7.
AIM: The quality of segmentation and three-dimensional reconstruction of anatomical structures in tomographic slices is often impaired by disturbances due to partial volume effects (PVE). The potential for artefact reduction by use of the morphological image processing operators (MO) erosion and dilation is investigated. DESIGN: The CT examinations of 31 patients with pathological alterations in lung or brain were segmented using automatic region growing and the MO were applied in a different number of iterations. The processed regions were 3D-reconstructed (shaded surface display, MIP, volume rendering) and the occurrence of PVE-related artefacts using the signal-to-background ratio (SBR) prior to and after MO application was compared. RESULTS: For all patients under review, the artefacts caused by PVE were significantly reduced by erosion (lung: mean SBRpre = 1.67, SBRpost = 4.83; brain: SBRpre = 1.06, SBRpost = 1.29) even with only a small number of iterations. Region dilation was applied to integrate further structures (e.g. at tumor borders) into a configurable neighbourhood for segmentation and quantitative analysis. CONCLUSIONS: The MO represent an efficient approach for the reduction of PVE artefacts in 3D-CT reconstructions and allow optimized visualization of individual objects. 相似文献
8.
Journal of Mathematical Imaging and Vision - A correction to this paper has been published: https://doi.org/10.1007/s10851-021-01028-0 相似文献
9.
Lasserre S Hernando J Hill S Schümann F Anasagasti Pde M Jaoudé GA Markram H 《IEEE transactions on visualization and computer graphics》2012,18(2):214-227
We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. Starting from manually sampled morphological points (3D points and diameters) from neurons in a brain slice preparation, we construct a polygonal mesh representation that realistically represents the continuous membrane surface, closely matching the original experimental data. A mapping between the original morphological points and the newly generated mesh enables simulations of electrophysiolgical activity to be visualized on this new membrane representation. We compare the new mesh representation with the state of the art and present a series of use cases and applications of this technique to visualize simulations of single neurons and networks of multiple neurons. 相似文献
10.
Yu. M. Lakhtin Ya. D. Kogan D. P. Shashkov L. G. Petrova 《Metal Science and Heat Treatment》1989,31(6):417-421
1. | During nitriding of nickel alloys which contain Ti in the temperature interval from 1000–1200°C for 5–15 h, the conditions are created for the formation of only internal nitriding and the formation of a nitride zone does not occur. These are prerequisites for increased heat resistance. |
2. | In nickel alloys containing a higher concentration of chromium, a zone of internal nitriding of large thickness occurs during the nitriding process. At the most intense levels of nitriding (t=1200°C and =15h) a through saturation of a 1.5-mm-thick sample of high chrome alloy 2 occurs. |
3. | As a result of nitriding nickel alloys which contain additions of titanium, there is an increase in strength due to the formation of dispersed particles of titanium nitride within the matrix. These particles inhibit the high temperature plastic flow. Another factor which increases the heat resistance of these alloys is the solubility of nitrogen in the matrix which increases the recrystallization temperature, and consequently, the high temperature strength. |
4. | In the alloy which contained the greater concentration of Cr, there is a more intense growth of the diffusion layer. On the other hand, the high concentration of Cr, the lower concentration of Ti, and the absence of Co are the reasons there is a lower increase in the heat resistance as a result of nitriding. |