The structure and function of platelet-activating factor acetylhydrolases

Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique and biologically important family of phospholipase A2s. They are related to neither the well-characterized secretory nor cytosolic PLA2s, and unlike them do not require Ca2+ for catalytic activity. The distinguishing property of PAF-AHs is their unique substrate specificity: they act on the phospholipid platelet-activating factor (PAF), and in some cases on proinflammatory polar phospholipids, from which they remove a short acyl moiety--acetyl in the case of PAF--located at the sn-2 position. Because PAF is found both in the plasma and in the cytosol of many tissues, PAF-acetylhydrolases are equally widely distributed in an animal organism. Recent crystallographic studies shed new light on the complex structure-function relationships in PAF-AHs.     

Polarized light reflectometer

The modulated reflected and nonreflected light fluxes, measured as the azimuth of incident linearly polarized light is varied, yield the absolute reflectances R(p), and R(s), of a dielectric or semiconductor surface. Application to a reflective Si detector determines the refractive index and thickness of a SiO(2) film on the detector surface.     

New aspect-oriented constructs for security hardening concerns

In this paper, we present new pointcuts and primitives to Aspect-Oriented Programming (AOP) languages that are needed for systematic hardening of security concerns. The two proposed pointcuts allow to identify particular join points in a program's control-flow graph (CFG). The first one is the GAFlow, Closest Guaranteed Ancestor, which returns the closest ancestor join point to the pointcuts of interest that is on all their runtime paths. The second one is the GDFlow, Closest Guaranteed Descendant, which returns the closest child join point that can be reached by all paths starting from the pointcut of interest. The two proposed primitives are called ExportParameter and ImportParameter and are used to pass parameters between two pointcuts. They allow to analyze a program's call graph in order to determine how to change function signatures for passing the parameters associated with a given security hardening. We find these pointcuts and primitives to be necessary because they are needed to perform many security hardening practices and, to the best of our knowledge, none of the existing ones can provide their functionalities. Moreover, we show the viability and correctness of the proposed pointcuts and primitives by elaborating and implementing their algorithms and presenting the result of explanatory case studies.     

Dyslipidemias and autoimmune diseases

The paper summarizes the results of over 30-year studies dealt with dyslipidemias and autoimmune diseases. The teaching of the antiphospholipid syndrome (APS) has aroused interest in the problem. The experience gained shows changes in the blood cholesterol transport system. Patients with systemic lupus erythematosus (SLE) have higher levels of low density lipoprotein cholesterol and lower concentrations of high density lipoprotein (HDL) cholesterol, apolipoprotein A than the controls. The quantitative and qualitative changes in particles result in decreased acceptance of cholesterol from the membrane of a cell and tissues, which promotes the development of vascular diseases. Lipoprotein (a) may be an additional risk factor for thrombosis chiefly of coronary arteries, in patients with SLE and APS. Increased levels of oxidized low density proteins having atherogenic activity were found mainly in patients with SLE. The use of corticosteroids causes the changes in the spectrum of blood lipids, which together with other factors (thrombosis, vasculopathy, thrombocytopenia, etc.) create good conditions for the development of atherosclerosis, which determines the necessity of correcting the parameters of blood lipid transport not only to prevent vascular disorders but to improve the general life prognosis in SLE patients.