Challenges in the Application of Stochastic Modal Identification Methods to a Cable-Stayed Bridge

This paper presents an analysis of the data collected in the ambient vibration test of the International Guadiana cable-stayed Bridge, which links Portugal and Spain, based on different output-only identification techniques: peak-picking, frequency domain decomposition, covariance-driven stochastic subspace identification, and data-driven stochastic subspace identification. The purpose of the analysis is to compare the performance of the four techniques and evaluate their efficiency in dealing with specific challenges involved in the modal identification of the tested cable-stayed bridge, namely the existence of closely spaced modes, the perturbation produced by the local vibration of stay-cables, and the variation of modal damping coefficients with wind velocity. The identified natural frequencies and mode shapes are compared with the corresponding modal parameters provided by a previously developed numerical model. Additionally, the variability of some modal damping coefficients is related with the variation of the wind characteristics and associated with a component of aerodynamic damping.     

Assessing pre- and post-deformation in the southern Arava Valley segment of the Dead Sea Transform, Israel by differential interferometry

Differential radar interferometry, using archived ERS data over the region of the Dead Sea Transform, allows to detect ground movement (subsidence or uplift) in playas within the southern Arava Valley segment of the Dead Sea Rift. These measurements are consistent with a mean displacement rate of about 0.4 cm/month, in the direction of the radar beam, during the 8-month period preceding the Nuweiba earthquake of 22 November 1995. In the 3 years following the earthquake, the measured rate was smaller by a factor of 10. These movements are not related to salt diapirs or water pumping activities in the area. The exact location, along faults, suggests a possible correlation with pre-seismic and post-seismic fault deformation.A simple fault model consistent with the observed phenomena associates the observed subsidence/uplift to right and left stepping en-echelon fault patterns related to inter-seismic tensional accumulation along the faults. Further observations are necessary on this site and similar fault areas to corroborate the correlation between seismic activity and the observed phenomena. Monitoring of these sites should continue with differential Global positioning system (GPS) measurements and radar interferometric analysis using Envisat and Radarsat as well as archived data (including J-ERS).     

Fabry Disease and the Heart: A Comprehensive Review

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene that result in a deficiency of the enzymatic activity of α-galactosidase A and consequent accumulation of glycosphingolipids in body fluids and lysosomes of the cells throughout the body. GB3 accumulation occurs in virtually all cardiac cells (cardiomyocytes, conduction system cells, fibroblasts, and endothelial and smooth muscle vascular cells), ultimately leading to ventricular hypertrophy and fibrosis, heart failure, valve disease, angina, dysrhythmias, cardiac conduction abnormalities, and sudden death. Despite available therapies and supportive treatment, cardiac involvement carries a major prognostic impact, representing the main cause of death in FD. In the last years, knowledge has substantially evolved on the pathophysiological mechanisms leading to cardiac damage, the natural history of cardiac manifestations, the late-onset phenotypes with predominant cardiac involvement, the early markers of cardiac damage, the role of multimodality cardiac imaging on the diagnosis, management and follow-up of Fabry patients, and the cardiac efficacy of available therapies. Herein, we provide a comprehensive and integrated review on the cardiac involvement of FD, at the pathophysiological, anatomopathological, laboratory, imaging, and clinical levels, as well as on the diagnosis and management of cardiac manifestations, their supportive treatment, and the cardiac efficacy of specific therapies, such as enzyme replacement therapy and migalastat.     

A formal representation for context-aware business processes

A business process is a set of activities performed in a coordinated manner within an organizational and technical environment that is aimed toward a business goal. The flexibility of a process is related to an understanding of the unexpected events that occur when people, systems and resources interact and require adjustments. Thus, business processes must be designed to respond to information about different events and their specificity. This information defines what the literature calls “context”. To broaden the perception of context in the case of a business process, this work proposes an approach to characterize the context of a business process activity in a given domain through conceptual models structured in layers. A case study was conducted to evaluate the proposal, which provided evidence of the applicability of the model.     

The use of topology optimization in disposing carbon fiber reinforcement for concrete structures

A topology optimization procedure is presented as a tool for determining the distribution of external strengthening of concrete slabs, using Carbon Fiber Reinforced Polymer (CFRP). Although the procedure is applied to slabs in this work, the technique can be used in any concrete structure to be reinforced. Numerical simulations are performed using the Finite Element Method, in combination with the automated topology optimization procedure, to indicate the optimal region for placement of the reinforcement. The influence of some aspects of the slab’s structural behavior on the optimization results is presented: concrete cracking, boundary conditions and reinforcement rate. A brief discussion is given of the similarity between the topology optimization results obtained by the maximum stiffness and ultimate strength criteria. Gains are found in the stiffness and strength of reinforced parts. A comparison with conventional reinforcement techniques demonstrates that topology optimization can be a useful tool for defining the region of reinforcement, allowing for material cost savings.     

New insights into the morphology of Trypanosoma cruzi reservosome

Reservosomes are late endosomes present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and are defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. They have been extensively described in Trypanosoma cruzi epimastigote: are bounded by a membrane unit, present an electron-dense protein matrix with electron-lucent lipid inclusions, being devoid of inner membranes. Here we performed a detailed ultrastructural analysis of these organelles using a variety of electron microscopy techniques, including ultrathin sectioning, uranyl acetate stained preparations, and freeze fracture, either in intact epimastigotes or in isolated reservosomes. New informations were obtained. First, both isolated and in situ reservosomes presented small profiles of inner membranes that are morphologically similar to the membrane surrounding the organelle. In uranyl acetate stained preparations, internal membrane profiles turned out to be longer than they appeared in ultrathin section images and traversed the organelle diameter. Internal vesicles were also found. Second, endocytosed cargo are not associated with internal vesicles and reach reservosomes on board of vesicles that fuse with the boundary membrane, delivering cargo directly into reservosome lumen. Third, electron-lucent bodies with saturated lipid core surrounded by a membrane monolayer and with unusual rectangular shape were also observed. Fourth, it was possible to demonstrate the presence of intramembranous particles on the E face of both internal vesicles and the surrounding membrane. Collectively, these results indicate that reservosomes have a complex internal structure, which may correlate with their multiple functions.     

A nonlinear position and attitude observer on SE(3) using landmark measurements

This paper addresses the problem of position and attitude estimation, based on landmark readings and velocity measurements. A derivation of a nonlinear observer on SE(3) is presented, using a Lyapunov function conveniently expressed as a function of the difference between the estimated and the measured landmark coordinates. The resulting feedback laws are explicit functions of the landmark measurements and velocity readings, exploiting the sensor information directly in the observer. The proposed observer yields almost global asymptotic stabilization of the position and attitude errors and exponential convergence in any closed ball inside the region of attraction. Also, it is shown that the asymptotic convergence of the estimation error trajectories is shaped by the landmark geometry and observer design parameters. The problem of non-ideal velocity readings is also considered, and the observer is augmented to compensate for bias in the angular and linear velocity measurements. The resulting position, attitude, and bias estimation errors are shown to converge exponentially fast to the desired equilibrium points, for bounded initial estimation errors. Simulation results are presented to illustrate the stability and convergence properties of the observer.     

On the design of multi‐rate tracking controllers: Application to rotorcraft guidance and control

This paper presents a new methodology for the design and implementation of gain‐scheduled controllers for multi‐rate systems. The proposed methodology provides a natural way to address the integrated guidance and control problem for autonomous vehicles when the outputs are sampled at different instants of time. A controller structure is first proposed for the regulation of non‐square multi‐rate systems with more measured outputs than inputs. Based on this structure, an implementation for a gain‐scheduled controller is obtained that satisfies an important property known as the linearization property. The implementation resembles the velocity implementation for single‐rate systems. The method is then applied to the problem of steering an autonomous rotorcraft along a predefined trajectory defined in terms of space and time coordinates. By considering a convenient error vector to describe the vehicle's dynamics, the trajectory tracking problem is reduced to that of regulating the error variables to zero. Because of the periodic multi‐rate nature of the onboard sensor suite, the controller synthesis is dealt with under the scope of linear periodic systems theory. Simulation results obtained with a full non‐linear rotorcraft dynamic model are presented and discussed. Copyright © 2010 John Wiley & Sons, Ltd.