排序方式: 共有7条查询结果,搜索用时 15 毫秒
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Tian-luoLEI Xue-junLI 《Acta pharmacologica Sinica》2004,25(11):1550-1551
AIM: Lovastatin is commonly used in the clinic to treat hypercholesterolemia. The aim of the present studies was to investigate whether lovastatin had an antitumor activity on lewis lung carcinoma and evaluate whether lovastatin had a direct effect on hemorheology in tumor model. METHODS: The C57 mice which with lewis lung carcinoma were treated with lovastatin at concentrations of 10, 20, and 40 mg/kg ig for 21 d. We exam- 相似文献
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Yan-huaLIN LuTIE Ai-huaLIU Xue-junLI 《Acta pharmacologica Sinica》2004,25(11):1555
AIM: To study the effect of oxygen/glucose-deprived (OGD)culture on the expression of a novel protein, brain-pancreas relative protein (BPRP), and the possible regulating mechanism in vitro. BPRP was a key protein found in our previous study of cerebral ischemia. METHODS: PC12 cells was selected and exposed to the Eagle‘s solution containing 1 mmol/L Na2S2O4 for 相似文献
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NingLU YanPAN Yan-huaLIN Jun-weiGAO Tian-luoLEI He-mingYU Xue-junLI 《Acta pharmacologica Sinica》2004,25(11):1550
Recently, many reports have linked aquaporin 1 (AQPI)protein overexpression with tumorigenesis, tumor growth and progression, but the underlying mechanisms on regulating of AQP1 protein expression are still not clear. We hypothesized that hypoxia might play an important role in AQP1 induction during tumorigenesis as well as at the late stages of tumor development. To prove this hypothesis, we studied the AQP1 相似文献
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YanPAN Jun-huaWANG He-mingYU Xue-junLI 《Acta pharmacologica Sinica》2004,25(11):1529
AIM: The endothelium is involved in the generation and the regulation of multiple physiological and pathological processes of blood vessels. Previously we confirmed low molecular weight heparin (LMWH) could inhibit tumor metastasis by protecting human umbilical vein endothelial cells (HUVEC). To understand the effects of LMWH on the protein expression of HUVEC, we performed a comprehensive proteomics to survey global changes in proteins after LMWH treatment in HUVEC cells. METHODS: 相似文献
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Curcumin (diferuloylmethane), a yellow colouring agent contained in the rhizome of Curcuma Longa (turmeric), has a wide array of pharmacological and biological activities, such as antioxidant, anti-inflammatory, immunomodulating and anticarcinogenic effects. In this study, curcumin was examined for the antidepressant and anti-stress effects in forced swimming, 相似文献
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Jun-weiGAO He-mingYU Qian-liuSONG Shu-xinLI Xue-junLI 《Acta pharmacologica Sinica》2004,25(11):1566-1567
AIM: To develop an osmotic water permeability assay.METHODS: We subcloned the rat AQP1 cDNA into pEGFPC3 vector. HEK293 cells were transfected with pEGFP-C3/AQP 1 or pEGFP-C3 and selected by G418. The expression of AQP1was detected by RT-PCR and Western blot. Confocal laser fluorescence microscopy was used to record the change of fluorescent density corresponding to the volume change of the cells 相似文献
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Xue-junLI YangXIANG Hui-kaiTIAN BingMA Xiao-haoYAO Hong-meiZHANG He-mingYU 《Acta pharmacologica Sinica》2004,25(11):1567-1568
Proteomics is a bridge that crosses genome to drug discovery. Proteomic studies will provide possible targets for therapeutic usage and moreover increase the efficiency of the downstream of drug discovery process. By using the 2-D electrophoresis combining with MS technology, which is most preva-lent techniques of proteome, we have identified more than 20 相似文献
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