全文获取类型
收费全文 | 1726篇 |
免费 | 168篇 |
国内免费 | 27篇 |
学科分类
医药卫生 | 1921篇 |
出版年
2023年 | 5篇 |
2022年 | 9篇 |
2021年 | 40篇 |
2020年 | 32篇 |
2019年 | 35篇 |
2018年 | 47篇 |
2017年 | 38篇 |
2016年 | 38篇 |
2015年 | 68篇 |
2014年 | 68篇 |
2013年 | 102篇 |
2012年 | 109篇 |
2011年 | 127篇 |
2010年 | 64篇 |
2009年 | 57篇 |
2008年 | 96篇 |
2007年 | 119篇 |
2006年 | 94篇 |
2005年 | 70篇 |
2004年 | 77篇 |
2003年 | 90篇 |
2002年 | 62篇 |
2001年 | 44篇 |
2000年 | 39篇 |
1999年 | 49篇 |
1998年 | 25篇 |
1997年 | 16篇 |
1996年 | 25篇 |
1995年 | 24篇 |
1994年 | 17篇 |
1993年 | 28篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 20篇 |
1988年 | 15篇 |
1987年 | 8篇 |
1986年 | 14篇 |
1985年 | 15篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1976年 | 6篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1969年 | 5篇 |
排序方式: 共有1921条查询结果,搜索用时 0 毫秒
1.
Magdalena Cortes Alessandro Lambiase Marta Sacchetti Silvia Aronni Stefano Bonini 陈旭 《美国医学会眼科杂志(中文版)》2006,18(1):30-32
泪管-耳-牙-指(趾)(LADD)综合征是一种具有多种表现的常染色体显性遗传疾病。最初在1967年由Levy报道。1例双侧泪液系统缺失、杯状耳、干嘴,以及牙、手臂和指(趾)异常的单发病例。之后一些新发现的临床表现,如肾脏异常、唾液腺缺乏、先天性髋脱位、先天性裂孔疝和横膈疝、感觉性耳聋和传导性耳聋、牙发育不全、四肢异常、口腔干燥和眼干都被报道与此综合征有关。 相似文献
2.
3.
N. J. Cortes B. Afzali D. MacLean D. J. A. Goldsmith H. O'Sullivan J. Bingham D. A. Lewis E. MacMahon C. Y. W. Tong G. Koffman 《American journal of transplantation》2006,6(10):2497-2499
Two organ recipients developed serologic evidence of syphilis infection after renal transplantation from a common deceased donor with a history of treated syphilis. Testing of donor serum for syphilis, which occurred after transplantation, gave results interpreted as consistent with past infection. However, subsequent serologic results in the recipients suggested transmission of infection at transplantation due to active infection of the donor. This may be explained by recent donor re-infection in view of the current syphilis epidemic in the United Kingdom. An initial error in the treatment of recipients further served to highlight unfamiliarity in managing this resurgent infection in the context of organ transplantation. 相似文献
4.
5.
CA von Arnim R Spoelgen ID Peltan M Deng S Courchesne M Koker T Matsui H Kowa SF Lichtenthaler MC Irizarry BT Hyman 《The Journal of neuroscience》2006,26(39):9913-9922
The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD). GGA1, a member of the Golgi-localized gamma-ear-containing ARF-binding (GGA) protein family, interacts with BACE and influences its subcellular distribution. We now report that overexpression of GGA1 in cells increased the APP C-terminal fragment resulting from beta-cleavage but surprisingly reduced Abeta. GGA1 confined APP to the Golgi, in which fluorescence resonance energy transfer analyses suggest that the proteins come into close proximity. GGA1 blunted only APP but not notch intracellular domain release. These results suggest that GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. GGA1 may act as a specific spatial switch influencing APP trafficking and processing, so that APP-GGA1 interactions may have pathophysiological relevance in AD. 相似文献
6.
Summary The diversity of antibodies in patients with scleroderma, mixed connective tissue disease or primary Raynaud's phenomenon could be used as a laboratory aid in the clinical diagnosis. In serum samples of 75 patients we screened for antinuclear antibodies (HEp 2 cells), anti DNA, soluble nucleoprotein and extractable nuclear antigens (Sm, rRNP, Ul-nRNP, SSA/Ro, SSB/La and Scl-70). Distinctive antinuclear antibodies pattern was identified in each group of patients. This immunologic profile is valuable for clinical diagnosis and the preferential association of certain autoantibodies with some diseases and not with others, suggest an antigen-driven stimulus for its production. 相似文献
7.
应用放射配体结合法证实大鼠胸腺内存在降黑素特异结合部位,该结合位点可以满足特异结合部位的基本条件:1.低结合容量;2.高亲和力;3.可饱和性;4.可逆性;5.对降黑素高度特异性。此外,该特异结合位点具昼夜节律;亚细胞分布的研究表明以细胞核含量最高,线粒体次之,并具有年龄依赖性降低,以出生时最高。 相似文献
8.
A Daponte Codina P Gutiérrez-Cuadra R Oca?a Riola J L Gurucelain Raposo J A Maldonado Pérez R Garrido de la Sierra J Serrano Aguilar J M Mayoral Cortes 《Revista espa?ola de salud pública》1999,73(2):233-242
BACKGROUND: The objective of this study was to estimate the relationship between the levels of air pollution and the daily mortality in the city of Huelva for the 1993-1996 period using the EMECAM methodology. METHODS: The number of daily deaths for all causes except external ones, the death rate of those over age 69, due to diseases of the circulatory system and for respiratory diseases were used as rate indicators. Four pollutants--SO2, PM10, NO2 and CO--were analyzed, the daily levels of which were furnished by the air pollution monitoring network in Huelva. Autoregressive Poisson regression models were constructed controlling by tendency, seasonality, temperature, humidity, flue and events out of the ordinary. RESULTS: For the mortality rate for all causes, a significant association impact was found to exist for the NO2 for the entire period (RR10 microgram/m3: 1.0414; CI95%: 1.0047-1.0794) and for the particles (PM10) for the cold half of the year (RR10 microgram/m3: 1.0358; CI95%: 1.007-1.0722). For the mortality in people over age 69, a significant relationship was found to exist for SO2 throughout the entire period (RR10 microgram/m3: 1.0606; CI95%: 1.0020-1.1227). A significant relationship to the mortality from respiratory disease particles (PM10) was found to exist for the cold half of the year (RR10 microgram/m3: 1.1412; IC95%: 1.0300-1.2644). There was no association of contaminants with cardiovascular mortality; also there was no association between levels of CO and mortality indicators. CONCLUSIONS: In Huelva, significant relationships have been found to exist between the current levels of air pollution resulting from particles, SO2 and NO2 and the daily mortality. The impact of these pollutants on the mortality is coherent with scientific literature, although in the case of Huelva, the extremely small number of daily deaths due to its small population and other factors limit the consistency thereof. 相似文献
9.
P. Cortina Greus J. L. Alfonso Sanchez I. Frasquet Pons C. Saiz Sanchez C. Cortes Vizcaino J. I. Gonzalez Arraez A. Sabater Pons S. Ruiz 《European journal of epidemiology》1992,8(6):770-775
After describing the evolution of mortality from ischaemic cardiopathy (IC) in Spain from 1951 to 1986, which is tending to stabilize in some age groups, and from cerebrovascular accidents (CVA), which is clearly declining, an attempt is made to relate these developments to the prevalence of the main risk factors (hypertension, cholesterol, tobacco) associated with IC and CVA. Certain advances, though of a limited number, have been made in recent years in the control of arterial hypertension in Spain, although campaigns on a national scale as in other countries have not been carried out. Regarding alimentary factors, there is an obvious increase in the consumption of food rich in proteins and animal fats, abandoning to a great extent the traditional Mediterranean diet, with health care action being limited to the improvement of nutrition education of the public. Furthermore, the consumption of tobacco has been increasing in Spain during the study period in spite of health legislation in force in recent years.It is therefore deduced that there is no obvious relationship between mortality due to IC and CVA and the prevalence of the main risk factors associated with these diseases, especially when taking into account that preventive actions on a public health level have been very limited.Corresponding author. 相似文献
10.
Uría González-Tova J Escalera Almendros C Sánchez Macias J Areal Calama J Sanfeliú Cortes F Ibarz Servio L Saladie Roig JM 《Actas urologicas espa?olas》2000,24(9):757-760
Case report of a new case of malignant mesothelioma of the tunica vaginalis testis. A mediterranean male age 62, presented with enlargement and swelling of the scrotum, treated as orchiepydidymitis within the previous 3 months. Physical and ultrasonography examination showed a left scrotal mass with extension to the skin of the scrotum. After surgery (orchiectomy and partial hemiscrotectomy) and histopathology diagnosis of locally advanced malignant mesothelioma, CT showed metastasis in retroperitoneum, Lung and Liver. The patient undergoes chemotherapy and radiotheraphy with a poor prognose. We review the diagnosis, histopathology and therapeutical approach for this uncommon kind of paratesticular tumor (less than 80 cases reported in the last 30 years). 相似文献