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Molecular characteristic of acute leukemias with t(16;21)/<Emphasis Type="Italic">FUS-ERG</Emphasis>
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Marc Thioux Agnesa Pillon Dana Samson Marie-Pierre de Partz Marie-Pascale Noël Xavier Seron 《Neurocase》2013,19(4-5):371-389
Abstract In this study, we examine the case of a patient (NM) who could comprehend and produce numerals despite impairment on comprehension tasks and a high degree of anomia for other categories of words. It will be claimed that NM suffered from an impairment to the semantic system affecting all categories except numerals and the series of days and months. The case of a patient presenting with the exact reverse dissociation has been described a few years ago by Cipolotti et al. (Brain 1991; 114: 619–37). We conclude that NM's pattern of performance provides evidence that numerals constitute a relevant and perhaps a distinct category at the semantic level. 相似文献
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Agnesa Panferova Marina Gaskova Eugenyi Nikitin Pavel Baryshev Natalia Timofeeva Anna Kazakova Viktor Matveev Ekaterina Mikhailova Alexander Popov Irina Kalinina Lili Hachatrian Aleksey Maschan Michael Maschan Galina Novichkova Yulia Olshanskaya 《International journal of laboratory hematology》2021,43(4):713-723
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Spellberg BJ Collins M Avanesian V Gomez M Edwards JE Cogle C Applebaum D Fu Y Ibrahim AS 《Journal of leukocyte biology》2007,81(3):632-641
Although granulocyte transfusion is a logical, therapeutic option for neutropenic patients with refractory infections, significant technical barriers have prevented its widespread use. A novel phagocyte transfusion strategy has been developed based on activation of a human myeloid cell line HL-60. To further define the potential for HL-60 cells to recapitulate white cell transfusions, a shortened duration of activation was evaluated, facile quality control markers were defined, and the impact of low-dose irradiation on cell function was determined. Three days of activation resulted in increased cell viability and in vitro candidacidal capacity but with slightly higher cell replication compared with 7 days of activation. Cell viability and several flow cytometric measurements were accurate, quality control markers for HL-60 activation. In combination with activation, low-dose irradiation abrogated replication while sparing the candidacidal effects of the HL-60 cells. Infusion of irradiated, activated HL-60 cells improved survival of neutropenic, candidemic mice significantly. In summary, activated, irradiated HL-60 cells are microbicidal, have virtually no replicative capacity, and are safe and effective at protecting neutropenic mice against an otherwise 100% fatal candidal infection. With continued development, this strategy to recapitulate neutrophil functions has the potential to serve as an effective alternative to granulocyte transfusions. 相似文献
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In this paper, we report the case of RS, a brain-damaged patient presenting with a disproportionate conceptual impairment for fruit and vegetables in comparison to animals and artefacts. We argue that such a finer-grained category-specific deficit than the living/nonliving dichotomy provides a source of critical evidence for assessing current alternative theories of conceptual organisation in the brain. The case study was designed to evaluate distinct expectations derived from the categorical and the knowledge-specific accounts for category-specific semantic deficits. In particular, the integrity of object-colour knowledge has been assessed in order to determine whether the patient's deficit for fruit and vegetables was associated with a deficit for that kind of knowledge, which has been claimed to be highly diagnostic for fruit and vegetables. The results showed that the patient's pattern of performance is consistent with theories assuming a topographical category-like organisation of conceptual knowledge in the brain. 相似文献
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Levchenko EV Dvoretskiĭ SIu Kanaev SV Shcherbakov AM Barchuk AS Matsko DE Tiuraeva EI Radzhadova ZA Semenova AI Karelov AE Gorokhov LV Komarov IV Avanesian AA Khokhlova EA 《Voprosy onkologii》2012,58(2):260-264
The locally advanced cancer of thoracic esophagus was treated by induction chemo-irradiation therapy (IHRT) with intraluminal medium dose-rate brachytherapy (IMBT). From July 2009 to February 2012 twenty five patients (mean age 54.3 +/- 1.3 years) were included in the study. The length of the primary tumor was up to 6 cm in 10 pts and more than 6 cm in 15 pts. Induction therapy consisted of three IMBT sessions (7 Gy X 3; q7d) and two cycles of chemotherapy (PF; q28d), 26-31 days later the surgery was performed. Subtotal resection of the esophagus type of I Lewis was performed in 23 pts, transtracheal extirpation of the esophagus was performed in 2 pts.In all the cases 3F lymphodissection was performed. After IHRT in 15 of 25 pts. was obtained complete or partial response, in 10 of 25 pts was obtained disease stabilization. Perioperative complications occurred in 17 (68%) patients receiving conservative treatment, one patient (4%) died of treatment complications. In 6 cases (24%) morphology had shown the complete regression of primary tumor. Thus, the combination of intraluminal medium dose-rate brachytherapy and chemotherapy lead to reduction of primary tumor local spread and can be an efficient factor in improving the results of surgical treatment. 相似文献
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Agnesa Avanesian Behnood Khodayari Jeffery S. Felgner Mahtab Jafari 《Biogerontology》2010,11(1):45-52
The discovery of life extension in Caenorhabditis elegans treated with anticonvulsant medications has raised the question whether these drugs are prospective anti-aging candidate
compounds. The impact of these compounds on neural modulation suggests that they might influence the chronic diseases of aging
as well. Lamotrigine is a commonly used anticonvulsant with a relatively good adverse-effects profile. In this study, we evaluated
the interaction between the impacts of lamotrigine on mortality rate, lifespan, metabolic rate and locomotion. It has been
proposed in a wide range of animal models that there is an inverse relationship between longevity, metabolic rate, and locomotion.
We hypothesized that the survival benefits displayed by this compound would be associated with deleterious effects on health
span, such as depression of locomotion. Using Drosophila as our model system, we found that lamotrigine decreased mortality and increased lifespan in parallel with a reduction in
locomotor activity and a trend towards metabolic rate depression. Our findings underscore the view that assessing health span
is critical in the pursuit of useful anti-aging compounds. 相似文献
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This is an analysis of treatment results data for conservative (endosurgical and radiation therapy) treatment of patients with inoperable locally advanced esophageal cancer receiving therapy in 1990-2011. The original treatment tactics including recanalization of tumor-compressed esophageal lumen (argon plasma coagulation +/- high-frequency surgery or chemical tumor necrolysis) with consequent combined radiotherapy resulted in clinical response in 79,5% of cases, 89,3% of patients retained the possibility of enteral nutrition. One-year overall survival (OS) was 68,9% (58,8% in patients receiving combined radiotherapy), 2-year OS was 22,7% and 21,2% respectively. 相似文献