Size Effects in Thin Face-Centered Cubic Metals for Different Complex Forming Loadings

Influence of the size effects on the mechanical behavior of face-centered cubic metals was studied for complex loadings close to microforming ones. The effect of a reduction in thickness (t) over grain size (d) ratio on the mechanical behavior for high-purity nickel and copper is investigated for three different loadings by tensile and Nakazima tests (plane strain conditions and balanced biaxial expansion). Experimental results highlight a strong degradation of the mechanical properties of Cu and Ni when the t/d ratio is reduced below a critical value, independently of the strain path. However, this effect occurs if the equivalent plastic strain is larger than a critical level which is strain path dependent and related to the stress triaxiality. The current study reveals that plastic anisotropy is also affected by size effects. An excellent correlation is obtained between the t/d ratio and the thickness reduction, through the mean normal plastic anisotropy parameter which is widely used to estimate sheet formability. A size effect map based on forming limit diagrams is proposed to depict the optimal conditions of microforming.     

EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation,and Induces NPM1c Degradation in NPM1 Mutant AML

Nucleophosmin-1 (NPM1) is a pleiotropic protein involved in numerous cellular processes. NPM1 shuttles between the nucleus and the cytoplasm, but exhibits a predominant nucleolar localization, where its fate and functions are exquisitely controlled by dynamic post-translational modifications (PTM). Sentrin/SUMO Specific Peptidase 3 (SENP3) and ARF are two nucleolar proteins involved in NPM1 PTMs. SENP3 antagonizes ARF-mediated NPM1 SUMOylation, to promote ribosomal biogenesis. In Acute Myeloid Leukemia (AML), NPM1 is frequently mutated, and exhibits an aberrant cytoplasmic localization (NPM1c). NPM1c mutations define a separate AML entity with good prognosis in some AML patients, rendering NPM1c as a potential therapeutic target. SENP3-mediated NPM1 de-SUMOylation induces resistance to therapy in NPM1c AML. Here, we demonstrate that the imidazoquinoxaline EAPB0503 prolongs the survival and results in selective reduction in the leukemia burden of NPM1c AML xenograft mice. Indeed, EAPB0503 selectively downregulates HDM2 expression and activates the p53 pathway in NPM1c expressing cells, resulting in apoptosis. Importantly, we unraveled that NPM1c expressing cells exhibit low basal levels of SUMOylation paralleled with high SENP3 and low ARF basal levels. EAPB0503 reverted these molecular players by inducing NPM1c SUMOylation and ubiquitylation, leading to its proteasomal degradation. EAPB0503-induced NPM1c SUMOylation is concurrent with SENP3 downregulation and ARF upregulation in NPM1c expressing cells. Collectively, these results provide a strong rationale for testing therapies modulating NPM1c post-translational modifications in the management of NPM1c AML.     

Experimental comparison of classical PID and model-free control: Position control of a shape memory alloy active spring

Shape memory alloys (SMA) are being more frequently integrated into engineering applications. These materials with their shape memory effect enable the simplification of mechanisms and the reduction in size of actuators. SMA parts can easily be activated by Joule effect but their modeling and consequently their control remains difficult. It is principally due to their non-linear hysteretic thermomechanical behavior. Most of successful control strategies applied to SMA actuators are not often suitable for industrial applications: they are particularly heavy and use the Preisach model or neural networks to model the hysteretic behavior of these materials; this kind of model is difficult to identify and to use in real time. This paper deals with an application of the new framework of model-free control (MFC) of an SMA-spring based actuator. This control strategy relies on new results for fast derivative estimation of noisy signals. Their main advantages are: its simplicity and its robustness. Experimental results and comparisons with PI control are presented that demonstrate the efficiency of this new control strategy.     

Solid state transformations of Au-Cu-Pt alloys studied by in-situ X-ray synchrotron radiation and DSC

Seven alloys of the ternary Au-Cu-Pt system, containing 75 or 76.5 wt.% Au with 0–15 wt.% Pt and heat-treated to a fully ordered condition, are examined using in-situ synchrotron radiation to determine transformation temperatures and phases formed, and to investigate mechanisms of ordering and disordering. These experiments are complemented by differential scanning calorimetry. Diffraction data show that the alloys can be separated into three groups according to their stable low-temperature ordered phase(s), namely L1₀, L1₂, or the two combined. Platinum increases transformation temperatures in comparison with binary AuCu, two-phase ordered alloys showing the highest transformation temperatures. Details of the evolution of the X-ray diffraction peak structures upon heating and cooling point to significant differences between mechanisms of disordering and ordering: whereas ordering visibly proceeds at significant undercooling by nucleation and growth, disordering appears, from the visible shifts in peak position, to progress in more homogeneous fashion within the alloy.     

Use of green roofs to solve storm water issues at the basin scale – Study in the Hauts-de-Seine County (France)

At the building scale, green roof has demonstrated a positive impact on urban runoff (decrease in the peak discharge and runoff volume). This work aims to study if similar impacts can be observed at a basin scale. It is particularly focused on the possibility to solve some operational issues caused by storm water.

For this purpose, a methodology has been proposed. It combines: a method to estimate the maximum roof area that can be covered by green roof, called green roofing potential, and an urban rainfall-runoff model able to simulate the hydrological behaviour of green roof.

This methodology was applied to two urban catchments, one affected by flooding and the other one by combined sewage overflow. The results show that green roof can reduce the frequency and the magnitude of such problems depending on the covered roof surface. Combined with other infrastructures, they represent an interesting solution for urban water management.     

Response of a metastable superconducting detector to55Fe irradiation below 400 mK

We report a preliminary analysis of the irradiation of a suspension of superheated superconducting grains by⁵⁵Fe at temperatures below 400 mK. The suspension comprised both Sn (20–25 micron) and Al (20 micron) grains in equal filling factors of 20%. The differential magnetic field sweep spectra exhibit a peak structure, which we discuss in terms of the absorption of the 6 keV Xray of the⁵⁵Fe decay and secondary excitations.     

Composition of Services with Mobile Code

Mobile code is slowly gaining acceptance but it is still not clear where it is really useful. If not used judiciously it may incur greater complexity of programming and degradation of performances. The goal of this paper is to show that mobile code is particularly well suited as a glue for the composition of immobile services, where flexibility and extensibility are necessary. To support our claim we describe two services and one application that have been programmed with mobile code in the context of active networking. We study the impact on the flexibility, complexity and performance of the resulting systems. We observe positive effects on flexibility and complexity and acceptable performance penalties.     

Self-assembly of amphiphilic liquid crystal block copolymers containing a cholesteryl mesogen: Effects of block ratio and solvent

We report on the self-assembly, in water and in bulk, of amphiphilic liquid crystal block copolymers consisting of a cholesterol-based smectic LC polymer block (PAChol) and poly(ethylene glycol) (PEG) block. Two series of block copolymers, PEG₄₅-b-PAChol and PEG₁₁₄-b-PAChol (45 and 114 are the degree of polymerization of PEG blocks) with different hydrophilic/hydrophobic weight ratios were synthesized and characterized in detail. Depending on the diblock composition, smectic polymer vesicles and/or nanofibers were formed by adding water into a dilute solution of copolymers in dioxane. If THF is used instead of dioxane as solvent, solid spherical aggregates were obtained upon water addition for PEG₄₅-b-PAChol series, while macroscopic precipitation occurred for PEG₁₁₄-b-PAChol series. The mesomorphic and microphase segregation structures of the block copolymers in bulk were studied by X-ray scattering, DSC and POM. The interdigital smectic A (SmA_d) phase with a lamellar period of 4.25 nm was detected in all block copolymers. For PEG₁₁₄-b-PAChol₅ (PEG/PAChol weight ratio = 66/34) and PEG₁₁₄-b-PAChol₁₂ (45/55), lamellar type of microphase segregation was observed.     

Microstructure,Hardness, and Residual Stress Distributions in T-Joint Weld of HSLA S500MC Steel

This paper investigates the characterization of the microstructure, hardness, and residual stress distributions of MIG-welded high-strength low-alloy S500MC steel. The T-joint weld for 10-mm-thick plates was joined using a two passes MIG welding technology. The contour method was performed to measure longitudinal welding residual stress. The obtained results highlighted a good correlation between the metallurgical phase constituents and hardness distribution within the weld zones. In fact, the presence of bainite and smaller ferrite grain size in the weld-fusion zone might be the reason for the highest hardness measured in this region. A similar trend of the residual stress and hardness distributions was also obtained.