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1.
Digant Gupta Christopher G Lis Sadie L Dahlk Jessica King Pankaj G Vashi James F Grutsch Carolyn A Lammersfeld 《Nutrition journal》2008,7(1):19
Background
Bioelectrical Impedance (BIA) derived phase angle is increasingly being used as an objective indicator of nutritional status in advanced cancer. Subjective Global Assessment (SGA) is a subjective method of nutritional status. The objective of this study was to investigate the association between BIA derived phase angle and SGA in advanced colorectal cancer. 相似文献2.
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Carl Bruch Stephanie Altman Mishkat Al-Moumin Jessica Troell Elana Roffman 《国际水资源开发杂志》2007,23(4):595-624
For millennia, countries in the Middle East and North Africa (MENA) region have developed laws, regulations and other rules to govern their scarce water. These laws have been updated in recent years. This review of the legal frameworks (including regulations, decrees and other rules) reveals both progress and gaps in managing water quality, water quantity and procedural aspects. Of note, while the general frameworks are usually in place, in many instances the necessary details are lacking to give effect to the goals. However, in some instances the legal frameworks governing water lack certain key principles or approaches. In order to effectively meet the growing demands on their water resources, MENA countries will need to further strengthen and develop their legal frameworks. 相似文献
4.
Snell-Johns Jessica; Mendez Julia L.; Smith Bradley H. 《Canadian Metallurgical Quarterly》2004,18(1):19
Various definitions exist for what constitutes family therapy. In this article, we consider family therapy to encompass any intervention that targets family interactions and conceptualizes problems as existing beyond individual clients. Numerous individual studies and several quantitative reviews have established family therapy as an effective treatment modality and the treatment of choice for many disorders. However, critiques of existing service provision highlight the unfortunate fact that numerous barriers to treatment exist at multiple levels of the broader ecology, preventing many families from benefiting from these services. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
Jessica A. Schroeder 《Journal of Materials Science》1988,23(9):3073-3082
The cohesive, mode I (tensile cleavage) fracture energy (or fracture toughness), G
Ic, of bulk tapered double cantilevered beam (TDCB) samples of a series of three epoxy thermoset networks was determined using a linear elastic fracture mechanics (LEFM) analysis. Networks of different crosslink density were obtained by mixing various amounts of an aromatic epoxy novolac and an aliphatic epoxy and crosslinking with an imidazole catalyst. Brittle, stick-slip fracture was observed for all formulations, with G
Ic increasing as the amount of aliphatic epoxy increased. However, fracture surface morphologies exhibited evidence of increasing plastic deformation as G
Ic increased. In the investigation of structure-property relationships for this series of thermoset networks, G
Ic was found to be inversely related to both network crosslink density and glass transition temperature (T
g). It was also found that the room temperature frequency of the glassy state transition (-transition) increased as fracture toughness increased. 相似文献
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Jessica M. Groenevelt Daniel J. Corey Prof. Charlie Fehl 《Chembiochem : a European journal of chemical biology》2021,22(11):1854-1870
All human cells use O-GlcNAc protein modifications (O-linked N-acetylglucosamine) to rapidly adapt to changing nutrient and stress conditions through signaling, epigenetic, and proteostasis mechanisms. A key challenge for biologists in defining precise roles for specific O-GlcNAc sites is synthetic access to homogenous isoforms of O-GlcNAc proteins, a result of the non-genetically templated, transient, and heterogeneous nature of O-GlcNAc modifications. Toward a solution, this review details the state of the art of two strategies for O-GlcNAc protein modification: advances in “bottom-up” O-GlcNAc peptide synthesis and direct “top-down” installation of O-GlcNAc on full proteins. We also describe key applications of synthetic O-GlcNAc peptide and protein tools as therapeutics, biophysical structure–function studies, biomarkers, and as disease mechanistic probes to advance translational O-GlcNAc biology. 相似文献
9.
Photoacoustic‐Guided Surgery with Indocyanine Green‐Coated Superparamagnetic Iron Oxide Nanoparticle Clusters 下载免费PDF全文
Jayesh P. Thawani Ahmad Amirshaghaghi Lesan Yan Joel M. Stein Jessica Liu Andrew Tsourkas 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(37)
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real‐time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable. This study has developed a novel contrast agent comprised solely of two Food and Drug Administration approved components, indocyanine green (ICG) and superparamagnetic iron oxide (SPIO) nanoparticles—with no additional amphiphiles or carrier materials, to enable preoperative detection by magnetic resonance (MR) imaging and intraoperative photoacoustic (PA) imaging. The encapsulation efficiency of both ICG and SPIO within the formulated clusters is ≈100%, and the total ICG payload is 20–30% of the total weight (ICG + SPIO). The ICG–SPIO clusters are stable in physiologic conditions; can be taken up within tumors by enhanced permeability and retention; and are detectable by MR. In a preclinical surgical resection model in mice, following injection of ICG–SPIO clusters, animals undergoing PA‐guided surgery demonstrate increased progression‐free survival compared to animals undergoing microscopic surgery. 相似文献
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