The performance of depressed-cladding single-mode fibers withdifferent b/a ratios

Depressed-cladding single-mode fibers with a first cladding-to-core ratio (b/a) ranging from seven to one and relative refractive-index differences of the core from 0.25 to 0.35% and of the cladding from 0 to -0.2% are investigated experimentally with respect to the LP₁₁ mode cutoff properties, the mode-field diameter, the dispersion, and the bending attenuation. Numerical calculations based on actual profile parameters of the bend loss and the mode-field diameter agree well with experiment. It is demonstrated that low attenuation and bend losses independent of b/a can be obtained if the cutoff wavelength is kept constant by adjusting the core radius, the core index or the index of the first cladding     

Metallurgical Studies of Austenitic Stainless Steel 304 under Warm Deep Drawing

Austenitic stainless steel 304 was deep drawn with different blank diameters under warm conditions using 20 t hydraulic press. A number of deep drawing experiments both at room temperature and at 150 ℃ were conducted to study the metallography. Also, tensile test experiments were conducted on a universal testing machine up to 700 ℃ and the broken specimens were used to study the fractography of the material using scanning electron microscopy in various regions. The microstructure changes were observed at limiting draw ratio （LDR） when the cup is drawn at different temperatures. In austenitic stainless steel, martensite formation takes place that is not only affected by temperature, hut also influenced by the rate at which the material is deformed. In austenitic stainless steel 304, dynamic strain regime appears above 300 ℃ and it decreases the formability of material due to brittle fracture as studied in its fractography. From the metallographic studies, the maximum LDR of the material is observed at 150 ℃ before dynamic strain regime. It is also observed that at 150 ℃, grains are coarse in the drawn cups at LDR.     

Effects of Particle Crushing in Stress Drop-Relaxation Experiments on Crushed Coral Sand

Stress relaxation and stress drop-relaxation tests have been performed to complement a test series performed to study strain rate, creep, and stress drop-creep effects on crushed coral sand. Drained experiments with constant effective confining pressure of 200 kPa were performed in which triaxial specimens of crushed coral sand were loaded to initial stress differences of 500, 700, and 900 kPa, followed by stress drops of 0, 100, 200, 300, and 400 kPa at which points the axial strains were kept constant while the axial stress relaxation and the volumetric strains were observed. The stress drops produced delays in initiation of stress relaxation that were proportional with the magnitudes of the stress drops. The experiments show that sands do not exhibit classic viscous effects, and their behavior is indicated as “nonisotach,” while the typical viscous behavior of clay is termed “isotach.” Thus, there are significant differences in the time-dependent behavior patterns of sands and clay. A mechanistic picture of time effects in sands is proposed.     

Shear Banding in True Triaxial Tests and Its Effect on Failure in Sand

The occurrence of failure, mechanisms that create failure, and soil behavior in the vicinity of failure have been investigated. One mechanism is smooth peak failure, in which the soil continues to behave as a continuum with uniform strains, and smooth peak failure is followed by strain softening. Another mechanism is shear banding, whose occurrence in the plastic hardening regime limits the strength of the soil. True triaxial tests have been performed on tall prismatic specimens of Santa Monica Beach sand at three relative densities in a modified version of a cubical triaxial apparatus to study the effect of shear banding on failure in the full range of the intermediate principal stress. The experiments show that the strength increases as b [=(σ2 ? σ3)/(σ1 ? σ3)] increases from 0 to about 0.18, remains almost constant until b reaches 0.85, and then decreases slightly at b = 1.0. Shear banding initiates in the hardening regime for b-values of 0.18–0.85. Thus, peak failure is caused by shear banding in this middle range of b-values, and a smooth, continuous 3D failure surface is therefore not generally obtained for soils.     

Time Effects Relate to Crushing in Sand

Based on previously obtained experimental results, a mechanistic picture of time effects in granular materials is presented. Accordingly, time effects are caused by grain crushing, which in turn is time dependent, as indicated by static fatigue of brittle materials. Triaxial compression tests have been performed on Virginia Beach sand at high pressures, where grain crushing is prevalent, to study effects of initial loading strain rates on subsequent amounts of creep and stress relaxation. Grain size distribution curves were determined after each test and the amount of crushing, as characterized by Hardin’s breakage factor, is related to the energy input to the triaxial specimens. A pattern emerges that indicates the importance of crushing for the axial and volumetric strains, while rearrangement and frictional sliding between intact grains play much smaller roles in the stress-strain and volume change behaviors of granular materials at high stresses and shear strains. Because particle crushing is a time-dependent phenomenon described as static fatigue or delayed fracture, the close relation between time effects and crushing in granular materials is established.     

Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8‐Hydroxyefavirenz Exhibit Divergence in Activation

Efavirenz (EFV), an antiretroviral that interacts clinically with co‐administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450. We tested whether its primary metabolite, 8‐hydroxyEFV (8‐OHEFV) can activate PXR and potentially contribute to PXR‐mediated drug–drug interactions attributed to EFV. Luciferase reporter assays revealed that despite only differing from EFV by an oxygen atom, 8‐OHEFV does not activate PXR. Corroborating this, treatment with EFV for 72 h elevated the mRNA abundance of the PXR target gene, Cyp3a11, by approximately 28‐fold in primary hepatocytes isolated from PXR‐humanized mice, whereas treatment with 8‐OHEFV did not result in a change in Cyp3A11 mRNA levels. FRET‐based competitive binding assays and isothermal calorimetry demonstrated that even with the lack of ability to activate PXR, 8‐OHEFV displays an affinity for PXR (IC₅₀ 12.1 μm ; K_D 7.9 μm ) nearly identical to that of EFV (IC₅₀ 18.7 μm ; K_D 12.5 μm ). The use of 16 EFV analogues suggest that other discreet changes to the EFV structure beyond the 8‐position are well tolerated. Molecular docking simulations implicate an 8‐OHEFV binding mode that may underlie its divergence in PXR activation from EFV.     

Turbulence structure and bank erosion process in a dredged channel

Riverbank erosion has significant geomorphological as well as anthropogenic consequences. The geomorphological impacts include form changes such as lateral channel migration, meanders, channel expansion, etc. The anthropogenic effects include the threat to floodplain human habitation, agricultural land, and stability of instream hydraulic structures and buried pipelines. Channel dredging for the extraction of sand and gravel has seen a multi-fold rise in the last few decades. Therefore, riverbank erosion response to channel mining gains importance in river basin management. Sandpits dredged in the riverbeds can significantly impact the downstream riverbank stability. In order to assess these impacts, we conducted a series of experiments at a laboratory scale in a recirculating water flume. Three riverbank slopes, 25° (gentle), 31° (equal to the angle of repose of the bank sediments), and 40° (steeper than the angle of repose), were tested along with a sandpit. Remarkable changes in the turbulence structure of riverbank flow were found due to the channel pit. Pit excavation directly impacts the fluvial erosion characteristics of the riverbank. Pit action increases the Reynolds shear stress fields in the near-bank flow, which causes progressive fluvial erosion of the berm at the bank toe. The erosivity of the main channel flow in the riverbank also leads to channel degradation, which increases the exposed height of the bank slope. Pit dredging leads to the generation of stronger ejection bursts which provide a mechanism for berm sediment mobility and erosion. The hydro morphological response of the riverbank due to sand mining was analysed, and process understandings are presented in the paper.     

Extraction of ursolic acid from Ocimum sanctum leaves: Kinetics and modeling

Ursolic acid (UA) is a triterpene compound which shows significant biological potential. This study deals with the optimization and kinetics of UA extraction from Ocimum sanctum (OS) leaves in a stirred batch extraction. The influence of various extraction parameters on the extraction yield has been studied. The optimum extraction conditions were extraction time 40 min, speed of agitation 1000 rpm, temperature 323 K, solute to solvent ratio of 1:120. This resulted in 11.21 mg of UA/g of dried leaf powder of OS. The extraction kinetics behavior of UA from OS revealed that the extraction of UA followed a first order kinetics. The kinetic expression developed by Spiro and Siddique was used and the model is in good agreement with the experimental results. The diffusion coefficient determined ranged from 2 × 10^?11 to 6.10 × 10^?11 m²/s for the all set of experiments. The activation energy for the extraction of UA was found to be E_a = 10.45 kJ/mol.