Depressive symptomatology in maritally discordant women and men: The role of individual and relationship variables.

Marital discord and depressive symptomatology have repeatedly been found to be associated, but little is known about variables that influence this relationship. Data were collected from 139 couples seeking marital therapy, and analyses were conducted separately by gender. For wives, lower problem-solving ability, physical aggression by the partner, and 1 relationship belief predicted depressive symptomatology after the variance due to marital discord was removed in regression analyses. In addition to these predictors, less spouse-specific assertiveness, unemployment, and 1 other relationship belief were associated with depressive symptomatology for women after the variance due to marital discord was removed in partial correlation analyses. For men, only lower problem-solving ability added to the prediction of depressive symptomatology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A log mining approach for process monitoring in SCADA

SCADA (supervisory control and data acquisition) systems are used for controlling and monitoring industrial processes. We propose a methodology to systematically identify potential process-related threats in SCADA. Process-related threats take place when an attacker gains user access rights and performs actions, which look legitimate, but which are intended to disrupt the SCADA process. To detect such threats, we propose a semi-automated approach of log processing. We conduct experiments on a real-life water treatment facility. A preliminary case study suggests that our approach is effective in detecting anomalous events that might alter the regular process workflow.     

Infants' sensitivity to optical flow for controlling posture.

Infants' sensitivity to optical flow for controlling sitting and standing was tested using a "moving room" in which all of the walls moved together, or only the side walls or front wall moved. Two questions motivated this research. (a) is the optical flow necessary for inducing postural compensations spatially distributed in the optic array? (b) Do visually induced compensations follow a developmental progression, or alternatively, emerge all at once? Experiment 1 was designed to test postural compensations by 14-month-old infants capable of standing in the moving room. Experiment 2 was designed to test postural compensations by 5- to 9-month-old infants who were passively supported while sitting in the moving room. The results revealed that partial flow is generally sufficient for inducing postural compensations, but that the amplitude and consistency of the response depend on the location of the flow in the optic array. In addition, there was evidence suggesting that compensatory responses become increasingly systematic during the second half of the first year. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples

Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.     

Isomerization Dynamics of Dicyanine A in n-Alcoholic Solution

The radiationless relaxation of dicyanine A molecules in n-alcohols methanol to butanol has been studied by picosecond fluorescence spectroscopy and time-resolved nonlinear spectroscopy. The fluorescence decay rates have been measured as a function of viscosity, temperature, and fluorescence wavelength. It is shown that the wavelength dependence can be explained by coexistence of two ground-state conformers. The intrinsic activation barrier for the nonradiative decay from the excited surface is very small, much less than 1 kcal/mol. In a particular solvent the time constants of the nonradiative relaxation show a linear dependence on the variation of viscosity. The experimental data are discussed in relation to the BFO theory (Bagchi, B.; Fleming, G.R.; Oxtoby, D.W. J. Chem. Phys. 1983, 78: 7375).     

Formalizing process-based risk with Value-Focused Process Engineering

Following calls to advance the integration of risk and business process modeling paradigms, this paper formalizes the process of incorporating risk into business process models through the principles of Value-Focused Process Engineering (VFPE). In doing so, the paper aims to extend the existing VFPE modeling notation to reflect a set of necessary constructs required to adequately represent risk in goal-oriented business-process models. The extended set of constructs is proposed to support a formal systems view of process-based risk. Process-based risk is formalized on the one hand, as a product of complex interactions between activity-based elements, and on the other hand, as a natural component of the value creation mechanism of an elementary function or a complex process. The proposed risk-aware VFPE formalism also formulates rules for decomposing risk in process models according to the organizational values, thereby enabling better risk visibility, reducing process complexity, and ensuring continuity of business processes.     

Comparative study of three training methods for enhancing process control performance: Emphasis shift training,situation awareness training,and drill and practice

Three training methods to improve attention management skills in process control were compared. Forty students from technical disciplines participated in a five-hour module of emphasis shift training (EST), EST combined with situation awareness training (EST/SA), and drill and practice (D&P) on a simulated process control task. Participants were then tested three times for 45 min each (immediately after training, two weeks after training, and six weeks after training) for system control performance and diagnostic performance on familiar and nonfamiliar fault states. D&P led to superior diagnostic performance on familiar system faults. EST/SA training supported the diagnosis of novel system faults. EST was less effective than expected for system control performance. Implications for training design in process control are discussed.     

Revealing the Changes in Saliva and Serum Proteins of Pigs with Meningitis Caused by Streptococcus Suis: A Proteomic Approach

Meningitis due to Streptococcus suis causes high mortality and morbidity on pig farms and has increasing zoonotic potential worldwide. Saliva proteome analysis would potentially be useful in elucidating pathophysiological changes and mining for new biomarkers to diagnose and monitor S. suis infection. The objective of this study was to investigate the changes in the salivary and serum proteome profile of piglets with meningitis. The LC-MS/MS TMT proteomic approach was used to analyze saliva and serum samples from 20 male piglets: 10 with meningitis and 10 healthy. In saliva, 11 proteins had higher and 10 had lower relative abundance in piglets with meningitis. The proteins with the highest relative abundance were metavinculin (VCL) and desmocollin-2 (DSC2). Adenosine deaminase (ADA) was selected for validation using a spectrophotometric assay and demonstrated excellent performance in the differentiation between healthy and pigs with meningitis due to S. suis. In serum, the most protruding changes occurred for one SERPIN and haptoglobin (HP). In saliva and serum, the highest number of proteins with altered abundance were linked, via the enrichment analysis, with platelet and neutrophil pathways. Overall, meningitis caused by S. suis resulted in specific proteome changes in saliva and serum, reflecting different pathophysiological mechanisms, and marking new potential biomarkers for this infection.     

Bacterial DNAemia in Alzheimer’s Disease and Mild Cognitive Impairment: Association with Cognitive Decline,Plasma BDNF Levels,and Inflammatory Response

Microbial dysbiosis (MD) provokes gut barrier alterations and bacterial translocation in the bloodstream. The increased blood bacterial DNA (BB-DNA) may promote peripheral- and neuro-inflammation, contributing to cognitive impairment. MD also influences brain-derived neurotrophic factor (BDNF) production, whose alterations contribute to the etiopathogenesis of Alzheimer’s disease (AD). The purpose of this study is to measure BB-DNA in healthy elderly controls (EC), and in patients with mild cognitive impairment (MCI) and AD to explore the effect on plasma BDNF levels (pBDNF), the inflammatory response, and the association with cognitive decline during a two-year follow-up. Baseline BB-DNA and pBDNF were significantly higher in MCI and AD than in EC. BB-DNA was positively correlated with pBDNF in AD, plasma Tumor necrosis factor-alpha (TNF-α), and Interleukin-10 (IL-10) levels in MCI. AD patients with BB-DNA values above the 50th percentile had lower baseline Mini-Mental State Examination (MMSE). After a two-year follow-up, AD patients with the highest BB-DNA tertile had a worse cognitive decline, while higher BB-DNA levels were associated with higher TNF-α and lower IL-10 in MCI. Our study demonstrates that, in early AD, the higher the BB-DNA levels, the higher the pBDNF levels, suggesting a defensive attempt; BB-DNA seems to play a role in the AD severity/progression; in MCI, higher BB-DNA may trigger an increased inflammatory response.     

Social desirability effects on computerized and paper-and-pencil questionnaires

The objectives of the present study were to determine the impact of computer administration of questionnaires on impression management (IM) and self-deceptive enhancement (SDE) and on the disclosure of sensitive information such as alcohol use and risky sex. College students (N = 301) completed several questionnaires in either a computer-administered or paper-and-pencil condition. Respondents who completed the survey on the computer scored significantly higher on SDE than those completing the survey on paper. No differences were found for IM. Respondents in the computer condition also reported a higher level of alcohol consumption and riskier sexual behaviors than those in the paper-and-pencil condition. It is possible that computer administration of surveys creates a social situation that produces a sense of disinhibition in respondents, and this sense of disinhibition may lead to greater reports of risky behaviors.