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Hamari Lotta Konttila Jenni Merikukka Marko Tuomikoski Anna-Maria Kouvonen Petra Kurki Marjo 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(2):506-525
Journal of Immigrant and Minority Health - Parental support is of paramount importance in the promotion of positive parenting, strengthening parenthood and protecting children from disadvantages... 相似文献
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Protocol for digital intervention for effective health promotion of small children—A cluster randomized trial 下载免费PDF全文
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Beáta Tóth Zsuzsanna Hamari Lajos Ferenczy János Varga F. Kevei 《Current genetics》1998,33(3):199-205
Previous mitochondrial transmission experiments between oligomycin-resistant and oligomycin-sensitive incompatible strains
of the A. niger aggregate bearing various mtDNA RFLP profiles resulted in a great variety of mitochondrial recombinants under selection pressure.
Apart from the recombinant mtDNAs, resistant clones harbouring unchanged RFLP profiles of resistant donor mtDNAs with the
recipient nuclear backgrounds were rarely isolated. These strains were anastomosed with nuclearly isogenic oligomycin-sensitive
recipient partners and the mitochondria of the resulting progeny were examined under non-selective conditions. These experiments
provide insights into events which are possibly similar to those occurring in nature. The heterokaryons obtained formed both
oligomycin-resistant and -sensitive sectors, most of which were found to be homoplasmons. Progenies harbouring oligomycin-resistant
and -sensitive mtDNAs may originate either from individual recombination events or be due to parental segregation. MtDNA recombination
might take place in the heterokaryons without selection by oligomycin. The most frequent recombinant types of mtDNA RFLP profiles
were indistinguishable from those recombinant mtDNAs which were frequently obtained under selection pressure from directed
transfer experiments between incompatible strains. We present evidence that mixed mitochondrial populations may influence
the compatibility reactions in the presence of an isogenic nuclear background, that recombination may take place without selection
pressure, and that the process does not require specific nuclear sequences of both parental strains.
Received: 20 October 1997 / 13 January 1998 相似文献
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Association of Self‐Perceived Physical Competence and Leisure‐Time Physical Activity in Childhood—A Follow‐Up Study 下载免费PDF全文
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S. Hamari T. Kirveskoski V. Glumoff P. Kulmala O. Simell M. Knip R. Veijola 《Scandinavian journal of immunology》2016,83(4):279-287
Our aim was to study whether the aberrant amount or function of regulatory T cells is related to the development of type 1 diabetes (T1D) in children. We also set out to investigate the balance of different T cell subtype markers during the T1D autoimmune process. Treg cells were quantified with flow cytometric assay, and the suppression capacity was analysed with a carboxyfluorescein succinimidyl ester (CFSE)‐based T cell suppression assay in children in various phases of T1D disease process and in healthy autoantibody‐negative control children. The mRNA expression of different T cell subpopulation markers was analysed with real‐time qPCR method. The proportion and suppression capacity of regulatory T cells were similar in seroconverted children at an early stage of beta cell autoimmunity and also in children with T1D when compared to healthy and autoantibody‐negative children. Significant differences were observed in the mRNA expression of different T cell subpopulation markers in prediabetic children with multiple (≥2) autoantibodies and in children with newly diagnosed T1D when compared to the control children. In conclusion, there were no quantitative or functional differences in regulatory T cells between the case and control groups in any phase of the autoimmune process. Decreased mRNA expression levels of T cell subtype markers were observed in children with multiple islet autoantibodies and in those with newly diagnosed T1D, probably reflecting an exhaustion of the immune system after the strong immune activation during the autoimmune process or a generally aberrant immune response related to the progression of the disease. 相似文献
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Kucsera J Yarita K Takeo K Yoshida S Gácser A Hamari Z Avasi Z Kevei F 《Journal of basic microbiology》2002,42(2):111-119
A method was devised for easy detection of intra-strain variability of the human pathogenic yeast Cryptococcus neoformans. Cultivation of strains on a medium containing Phloxin B resulted in different coloured colonies. Generally, colonies were either pink or red; however there were also several colony-colour segregant in which both colours could be observed. A number of these segregants were isolated and analysed. Virulence factors such as the cell and capsule sizes were measured; further temperature sensitivity, growth rates, mating-types and melanin production were also studied. Segregants were examined by random amplified polymorphic DNA (RAPD) fingerprinting and electrophoretic karyotyping by pulsed-field gel electrophoresis (CHEF). They showed both phenotypic and genotypic differences. The main differences appeared in phenotypic characters and RAPD patterns; while the chromosomal patterns remained unchanged. Reversion frequency analysis revealed that the reason for this segregation could be due to phenotypic switching. The physiological reason for the colour changes was also investigated and was attributed to the differential ability of the cells to accumulate Phloxin B either into their capsules or into their cells. The method described here is potentially applicable for the detection of strain heterogeneity in both basic and clinical microbiology laboratories. 相似文献
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Amanda Wurz Emma McLaughlin Carolina Chamorro Via Sarah L. Grimshaw Lotta Hamari Miriam Gtte Sabine Kesting Francesca Rossi Patrick van der Torre Gregory M. T. Guilcher Krista McIntyre S. Nicole Culos-Reed 《Current oncology (Toronto, Ont.)》2021,28(1):619
The field of pediatric exercise oncology explores the relationships between physical activity (PA), including exercise, and a range of outcomes among children and adolescents affected by cancer. Although PA is safe and beneficial for this population, several important gaps in knowledge and practice remain. In this article, we describe research and innovation needs that were developed with a team of international experts and relevant literature, a series of online surveys, and an in-person meeting. Addressing these needs will contribute valuable knowledge and practice outputs to advance this field, ultimately enabling a greater number of children and adolescents affected by cancer to realize the benefits of moving more. 相似文献