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正垂体细胞瘤(pituicytoma,PC)是一种起源于神经垂体或漏斗部、由梭形双极细胞呈束状或席纹样排列的局限性实性低级别神经胶质瘤,与鞍区颗粒细胞瘤、梭形细胞嗜酸细胞瘤共同表达由NKX2-1基因编码的TTF-1,提示可能属于基底前脑相关肿瘤谱系成员。其成员间不仅需要相互厘清,而且要同一些形似者鉴别,更重要的是,必须排除肺或甲状腺癌颅内转移。大体上,PC多为实性,偶有囊性变,体积小,界线清,质韧、有弹性。镜下间质小血管丰富,而内皮细胞无增生,部分瘤细胞周围血 相似文献
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目的 通过研究明确苗药五藤膏外敷缓解胶原诱导性关节炎(CIA)大鼠关节局部炎症和骨破坏的机制,证实苗医外治就近驱邪的作用。方法 将70只Wistar大鼠随机分为空白组、模型组、苗药五藤膏高、中、低剂量组、扶他林组及IL-17阻断组,每组10只。除空白组外,其余6组均构建CIA模型,并给予相应的外敷治疗。观察大鼠一般情况,HE染色进行病理学分析,TRAP染色检测OC生成,ELISA检测各炎症因子的含量,RT-PCR和WB分别检测RANKL的基因及蛋白表达。结果 苗药五藤膏能改善CIA大鼠破骨细胞浸润及关节病理性结构,并降低RANKL蛋白、基因表达以及TNF-α、IL-1、IL-6、IL-17含量。结论 苗药五藤膏外敷剂对CIA大鼠的治疗机制可能与降低致炎因子的分泌,抑制RANKL及OC的表达相关。 相似文献
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本文对1例原发性肺脏淋巴瘤患者的临床资料及中医药诊治过程进行分析,并结合国内外相关文献进行总结。原发性肺淋巴瘤临床表现主要有:咳嗽、胸痛、喘气、呼吸困难等,影像学上无特异征象,确诊需病理诊断。本病早期可行根治性手术切除,晚期以化疗为主,根据病理分型选择不同化疗方案,根据辨证特点进行中药治疗,亦可取得一定疗效。原发性肺脏淋巴瘤罕见且无特异性表现,病理是其必要的诊断依据,根据病理及分期情况选择合适的治疗方案,老年患者可考虑中药或中西医结合治疗。由于本病罕见,故未检索到其他使用纯中药治疗本病案例,因此中药治疗本病的重复性尚需考证。 相似文献
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Objective: To observe the efficacy and the influence on quality of life (QOL) of syndrome differentiation treatment with Chinese medicine (CM) for opioid-induced constipation as well as the safety and influence on analgesic effect of opioids. Methods: Totally 406 cases enrolled from 53 collaborating medical centers were randomly assigned to a CM group and a control group. The CM group were treated with CM decoction based on syndrome differentiation, and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score (CCS), numedcal rating scale (NRS) of pain and Chinese version of European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire-C30 V3.0 (EORTC QLQ-C30 V3.0) were used to evaluate the efficacy, pain controlled and QOL status. Results: The comparisons of CCS score reduction and QOL between the two groups after treatment suggested that the improvements of constipation and QOL in the CM group were better than that in the control group (P〈0.05). The total efficiency of the CM group was better than the control group (93.5% vs. 86.4%, P〈0.05). There was no significant difference in NRS scores between before and after treatment in both groups. There was no serious drug-related adverse event during the course of study. Conclusion: CM decoction could effectively treat opioid-induced constipation and improve patients' QOL at the same time. It is safe and doesnt affect the analgesic effect of opioids when treating constipation. 相似文献
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陈昌明 《中药新药与临床药理》2016,27(4)
目的研究益气除痰方对BALB/c-nu裸小鼠A549肺癌肿瘤生长及转移的抑制作用并初步探讨其作用机制。方法构建裸鼠A549肺癌移植瘤模型,随机分为空白对照组和益气除痰方组(15.5 g·kg~(-1)·d~(-1)),连续灌胃给药21 d,期间每3天测体质量和瘤体体积;21 d后脱颈处死小鼠,剥取瘤体测瘤质量,计算抑瘤率;摘取肺组织,固定后观察肺表面转移灶个数,计算肺转移抑制率;采用免疫组化法检测瘤体组织上皮间质转化(EMT)标志物及相关信号蛋白表达。结果与空白对照组比较,益气除痰方组小鼠的瘤体体积和瘤质量明显下降(P0.05),抑瘤率为27.6%,提示益气除痰方对肿瘤的生长具有一定的抑制作用;益气除痰方组小鼠肺转移结节明显少于对照组(P0.05),其转移抑制率为39.6%,提示益气除痰方在体内可抑制肺癌的转移;益气除痰方组瘤体组织的上皮标志蛋白E-cadherin较对照组升高(P0.05),而EMT关键标志蛋白vimentin和fibronectin明显下降(P0.05),提示益气除痰方可抑制EMT的发生,从而降低肿瘤细胞的侵袭转移能力;益气除痰方组的GRP78、smad2/3、SRC、P38、ERK、JNK的表达及其磷酸化激活程度均较对照组下降(P0.05),提示益气除痰方抑制肿瘤生长及其抑制EMT的作用可能与其多靶点抑制GRP78、smad2/3、SRC、P38、ERK、JNK等信号蛋白有关。结论益气除痰方可抑制肺癌肿瘤细胞的生长并抑制肺癌的转移,其抑制肿瘤转移的机制与其抑制细胞EMT的发生有关。益气除痰方可能通过多靶点的抑制GRP78、smad2/3、SRC、MAPK(JNK、P38、ERK)等信号通路来实现对EMT的逆转作用。 相似文献