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1.
Continuous reverse k nearest neighbors queries in Euclidean space and in spatial networks 总被引:2,自引:0,他引:2
Muhammad Aamir Cheema Wenjie Zhang Xuemin Lin Ying Zhang Xuefei Li 《The VLDB Journal The International Journal on Very Large Data Bases》2012,21(1):69-95
In this paper, we study the problem of continuous monitoring of reverse k nearest neighbors queries in Euclidean space as well as in spatial networks. Existing techniques are sensitive toward objects
and queries movement. For example, the results of a query are to be recomputed whenever the query changes its location. We
present a framework for continuous reverse k nearest neighbor (RkNN) queries by assigning each object and query with a safe region such that the expensive recomputation is not required as long as the query and objects remain in their respective safe regions.
This significantly improves the computation cost. As a byproduct, our framework also reduces the communication cost in client–server
architectures because an object does not report its location to the server unless it leaves its safe region or the server
sends a location update request. We also conduct a rigid cost analysis for our Euclidean space RkNN algorithm. We show that our techniques can also be applied to answer bichromatic RkNN queries in Euclidean space as well as in spatial networks. Furthermore, we show that our techniques can be extended for
the spatial networks that are represented by directed graphs. The extensive experiments demonstrate that our techniques outperform
the existing techniques by an order of magnitude in terms of computation cost and communication cost. 相似文献
2.
3.
Equivalent conductances of Bu4NBPh4, Bu4NNO3, Bu4NI,KClO4, Kl, NaI, NaBPh4, Ph4PCl, LiCl, AgNO3 and CuClO4. 4AN have been measured at 25°C in binary mixtures of N,N-dimethylformamide (DMF) containing 1 mol % of 1, 1, 3, 3-tetramethylurea (TMU), dimethylsulphoxide (DMSO) and hexamethylphosphotriamide (HMPT). Such measurements for LiCl, NaI, KClO4 and CuClO4. 4AN have also been carried out in DMF and in binary mixtures of DMF containing 1 mol % pyridine (Py), α-picoline (α-Pic), β-picoline (β-Pic), γ-picoline (γ-Pic) and acetonitrile (AN). The conductance data in all the cases have been analyzed by the Shedlovsky equation. Limiting ion conductances have been obtained by the method of Fuoss et al. The actual solvated radii of ions, evaluated using limiting ion conductances show that Ag+ and Cu+ have strong preferential solvation by all solvents which have been used to prepare the binary mixtures with DMF and the preferential solvation for both Ag+ and Cu+ with HMPT, DMSO and TMU is relatively stronger than with AN and is practically of similar magnitude as with the organic bases. 相似文献
4.
The binding of orally dosed hydrophobic active pharmaceutical ingredients to casein micelles in milk
Casein proteins (αS1-, αS2-, β- and κ-casein) account for 80% of the total protein content in bovine milk and form casein micelles (average diameter = 130 nm, approximately 1015 micelles/mL). The affinity of native casein micelles with the 3 hydrophobic active pharmaceutical ingredients (API), meloxicam [351.4 g/mol; log P = 3.43; acid dissociation constant (pKa) = 4.08], flunixin (296.2 g/mol; log P = 4.1; pKa = 5.82), and thiabendazole (201.2 g/mol; log P = 2.92; pKa = 4.64), was evaluated in bovine milk collected from dosed Holstein cows. Native casein micelles were separated from raw bovine milk by mild techniques such as ultracentrifugation, diafiltration, isoelectric point precipitation (pH 4.6), and size exclusion chromatography. Acetonitrile extraction of hydrophobic API was then done, followed by quantification using HPLC-UV. For the API or metabolites meloxicam, 5-hyroxy flunixin and 5-hydroxy thiabendazole, 31 ± 3.90, 31 ± 1.3, and 28 ± 0.5% of the content in milk was associated with casein micelles, respectively. Less than ~5.0% of the recovered hydrophobic API were found in the milk fat fraction, and the remaining ~65% were associated with the whey/serum fraction. A separate in vitro study showed that 66 ± 6.4% of meloxicam, 29 ± 0.58% of flunixin, 34 ± 0.21% of the metabolite 5-hyroxy flunixin, 50 ± 4.5% of thiabendazole, and 33 ± 3.8% of metabolite 5-hydroxy thiabendazole was found partitioned into casein micelles. Our study supports the hypothesis that casein micelles are native carriers for hydrophobic compounds in bovine milk. 相似文献
5.
Tarik Ali Cheema Alexander Lichtner Christine Weichert Markus Böl Georg Garnweitner 《Journal of Materials Science》2012,47(6):2665-2674
Optically transparent nanocomposites with enhanced mechanical properties were fabricated using stable dispersions of sub 10 nm
ZrO2 nanoparticles. The ZrO2 dispersions were mixed with a commercially available bisphenol-A-based epoxy resin (RIMR 135i) and cured with a mixture of
two amine-based curing agents (RIMH 134 and RIMH 137) after complete solvent removal. The colloidal dispersions of ZrO2 nanoparticles, synthesized through a non-aqueous approach, were obtained through a chemical modification of the ZrO2 nanoparticle surface, employing different organic ligands through simple mixing at room temperature. Successful binding of
the ligands to the surface was studied utilizing ATR–FT-IR and thermogravimetric analysis. The homogeneous distribution of
the nanoparticles within the matrix was proven by SAXS and the observed high optical transmittance for ZrO2 contents of up to 8 wt%. Nanocomposites with a ZrO2 content of only 2 wt% showed a significant enhancement of the mechanical properties, e.g., an increase of the tensile strength
and Young’s modulus by up to 11.9 and 12.5%, respectively. Also the effect of different surface bound ligands on the mechanical
properties is discussed. 相似文献
6.
Meeta Lavania Jyotsana Dalal Simrita Cheema Chandra Shekhar Nautiyal Banwari Lal 《European Food Research and Technology》2011,232(4):703-711
This study represents a comprehensive analysis and scientific validation of our ancient knowledge about the ethnopharmacological
aspects of cow urine by measuring the lipid peroxidation, radical scavenging, and level of reduced glutathione and catalase
activity. Graded doses of cow urine were administered orally to experimentally treated rats. Results of liver and plasma from
experimentally treated rats indicated that cow urine reduced the levels of thiobarbituric acid reactive substance significantly
in all the treatments (P < 0.01). In vitro experiments with the liver of control and experimentally treated rats were also carried out against cumene
hydroperoxide-induced lipid peroxidation. On LCMS analysis, the antioxidant component of cow urine was identified as uric
acid (m/z 169.07). The results demonstrate that the cow urine-mediated induction of antioxidant level controls oxidative damage,
even after minimal processing, and thus is indicative of its potential as a viable substitute of synthetic antioxidants. 相似文献
7.
U. Cheema C.‐B. Chuo P. Sarathchandra S. N. Nazhat R. A. Brown 《Advanced functional materials》2007,17(14):2426-2431
Variation in collagen fibril diameter in nature is a major factor determining biological material properties. However, the mechanism resulting in this fibril diameter difference is not clear and generally assumed to be cell‐dependent. It is certainly not possible so far to engineer this into implantable scaffold materials. This gap in our knowledge is crucial for the fabrication of truly biomimetic tissue‐like materials. We have tested the idea that fibril diameter can be regulated directly without cell involvement, using cyclical mechanical loading to promote fibril fusion. Specific loading regimes increased collagen fibril diameter (> 2 fold) in direct relation to cycle number, whilst thin fibrils disappeared. Tensile properties increased, producing a 4.5 fold rise in break strength. This represents the first demonstration of direct cyclical load‐promoted fibril fusion and provides a direct relation with material properties. The ability to control material properties in this way makes it possible to fabricate truly biomimetic collagen materials without cells. 相似文献
8.
A new approach for the template image matching is being presented. The method first converts the image into edges, then, the
vital information of these edges has been presented as a set of vectors in a four dimensional hyper-space. A modified Radon
Transform has been proposed to facilitate this vectorization process. All the above processing is being done offline for the
main image of the area. The template image has also been vectorized in a same fashion in real time which is to be matched
with the main image. A vector matching algorithm has been proposed to deliver match location with a very low computational
cost. It works for a wide range of template scaling and noise conditions which were not there in the previous algorithms found
in the literature. 相似文献
9.
AR Padhani WW Scott M Cheema D Kearney YS Erozan 《Canadian Metallurgical Quarterly》1997,32(8):453-458
RATIONALE AND OBJECTIVES: The authors evaluate the role of immediate cytologic evaluation (ICE) with fine-needle aspiration biopsy (FNAB) for lung lesions at highest risk for pneumothorax. METHODS: A prospective randomized study was conducted of 80 patients with lung lesions surrounded by aerated parenchyma undergoing FNAB with and without ICE (47 and 33 patients, respectively). An analysis of needle passes, procedure time, complications, specimen adequacy, diagnostic yield, and accuracy of procedure was made. RESULTS: There was an increased number of needle passes with ICE (> or = three passes: 23% [11 biopsies] versus 3% [1 biopsy]; P = 0.01). Fluoroscopic procedures took longer with ICE (median time: 15 versus 9 minutes; P = 0.002) with no difference in complication rates. Specimen adequacy was similar (74% and 64%) and the procedure was diagnostic in 79% (37 biopsies) with ICE and in 70% (33 biopsies) without ICE. There were no significant differences in the sensitivity, specificity, or accuracy of the biopsy. CONCLUSIONS: Immediate cytologic evaluation improved results marginally with increased procedure time and needle passes. Immediate cytologic evaluation may be most useful for lesions at lowest risk of complications to assure that a second procedure is not required. 相似文献
10.
SH Murch PJ Winyard S Koletzko B Wehner HA Cheema RA Risdon AD Phillips N Meadows NJ Klein JA Walker-Smith 《Canadian Metallurgical Quarterly》1996,347(9011):1299-1301
BACKGROUND: The molecular basis of protein-losing enteropathy is unknown. However it has been shown that sulphated glycosaminoglycans may be important in regulating vascular and renal albumin loss. METHODS: We describe three baby boys who presented within the first weeks of life with massive enteric protein loss, secretory diarrhoea, and intolerance of enteral feeds. All required total parenteral nutrition and repeated albumin infusions. No cause could be found in any case despite extensive investigations, including small intestinal biopsy sampling, which were repeatedly normal. FINDINGS: By specific histochemistry, we detected gross abnormality in the distribution of small intestinal glycosaminoglycans in all three infants, with complete absence of enterocyte heparan sulphate. The distribution of vascular and lamina propria glycosaminoglycans was, however, normal. INTERPRETATION: The presentation of these infants suggests that enterocyte heparan sulphate is important in normal small intestinal function. 相似文献