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1.
Repeated reference creates strong expectations in addressees that a speaker will continue to use the same expression for the same object. The authors investigate the root reason for these expectations by comparing a cooperativeness-based account (Grice, 1975) with a simpler consistency-based account. In two eye-tracking experiments, the authors investigated the expectations underlying the effect of precedents on comprehension. The authors show that listeners expect speakers to be consistent in their use of expressions even when these expectations cannot be motivated by the assumption of cooperativeness. The authors conclude that though this phenomenon seems to be motivated by cooperativeness, listeners' expectation that speakers be consistent in their use of expressions is governed by a general expectation of consistency. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Shlomzion Aumann Adir Shaulov Arnon Haran Noa Gross Even-Zohar Vladimir Vainstein Boaz Nachmias 《International journal of molecular sciences》2022,23(18)
Venetoclax, a B-cell lymphoma (BCL-2) inhibitor, in combination with hypomethylating agents has become the new standard of care in elderly and unfit patients with acute myeloid leukemia, with significantly improved overall survival and quality of life. Studies of venetoclax combined with high-dose chemotherapy are emerging with evidence of higher rates of molecular remission. Recently, a growing number of publications bring forth the use of venetoclax in patients with acute lymphoblastic leukemia (ALL). In the current review, we present the biological rationale of BCL-2 inhibition in ALL, how the interplay of BH3 proteins modulate the response and the current clinical experience with various combinations. 相似文献
4.
Itzik Cooper Katayun Cohen-Kashi Malina Yishai Levin Alexandra Gabashvili Boaz Mohar Alfredo Cagnotto Mario Salmona Vivian I. Teichberg 《International journal of molecular sciences》2022,23(20)
The mechanisms involved in the interaction of PrP 106-126, a peptide corresponding to the prion protein amyloidogenic region, with the blood–brain barrier (BBB) were studied. PrP 106-126 treatment that was previously shown to impair BBB function, reduced cAMP levels in cultured brain endothelial cells, increased nitric oxide (NO) levels, and changed the activation mode of the small GTPases Rac1 (inactivation) and RhoA (activation). The latter are well established regulators of endothelial barrier properties that act via cytoskeletal elements. Indeed, liquid chromatography-mass spectrometry (LC-MS)-based proteomic profiling study revealed extensive changes in expression of cytoskeleton-related proteins. These results shed light on the nature of the interaction between the prion peptide PrP 106-126 and the BBB and emphasize the importance of the cytoskeleton in endothelium response to prion- induced stress. 相似文献
5.
Sharona Khier Sandra Tolchinsky Gerardo Z. Lederkremer Boaz Shaanan 《Israel journal of chemistry》1994,34(2):177-184
A model for the carbohydrate recognition domain (CRD) and combining site of the human asialoglycoprotein (ASGP) receptor has been computed on the basis of the close sequence homology with the mannose-binding lectin (MBP), whose three-dimensional structure in complex with a ligand has been determined by crystallographic methods (Weis, W.I.; Drickamer, K.; Hendrickson, W.A. Nature 1992, 360: 127). Within the limitations of modeling methods, the model is compatible with data on ligand binding of the family C-type lectins, of which the MBP and the ASGP receptor are members. The model derived can serve as a guide for designing site-directed mutagenesis experiments in order to further elucidate the origins of specificity of the ASGP receptor toward galactose. In particular, the model focuses attention on the possible role of position 207 (MBP sequence numbering) in promoting galactose binding. 相似文献
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The paper focuses on mining clusters that are characterized by a lagged relationship between the data objects. We call such
clusters lagged co-clusters. A lagged co-cluster of a matrix is a submatrix determined by a subset of rows and their corresponding lag over a subset
of columns. Extracting such subsets may reveal an underlying governing regulatory mechanism. Such a regulatory mechanism is
quite common in real-life settings. It appears in a variety of fields: meteorology, seismic activity, stock market behavior,
neuronal brain activity, river flow, and navigation, but a limited list of examples. Mining such lagged co-clusters not only
helps in understanding the relationship between objects in the domain, but assists in forecasting their future behavior. For
most interesting variants of this problem, finding an optimal lagged co-cluster is NP-complete problem. We present a polynomial-time
Monte-Carlo algorithm for mining lagged co-clusters. We prove that, with fixed probability, the algorithm mines a lagged co-cluster
which encompasses the optimal lagged co-cluster by a maximum 2 ratio columns overhead and completely no rows overhead. Moreover,
the algorithm handles noise, anti-correlations, missing values, and overlapping patterns. The algorithm is extensively evaluated
using both artificial and real-world test environments. The first enable the evaluation of specific, isolated properties of
the algorithm. The latter (river flow and topographic data) enable the evaluation of the algorithm to efficiently mine relevant
and coherent lagged co-clusters in environments that are temporal, i.e., time reading data and non-temporal. 相似文献
8.
One of the most fascinating properties of materials in nature is the superhydrophobic and self‐cleaning capabilities of different plant surfaces. This is usually achieved by the hydrophobic cuticles that are made of cutin and contain wax crystals both within them and on their surfaces. Here, bioinspired n‐hexatriacontane wax films are deposited via thermal evaporation and it is shown that the surface evolves in time via self‐assembly. This leads to a dramatic change in the wetting properties with a transition from hydrophobic to superhydrophobic characteristics, which takes place within several days at room temperature. This phenomenon is investigated and strain‐induced recrystallization is proposed to be the mechanism for it. This work could become the basis for the inspiration and production of tuned, time‐dependant, temperature‐sensitive, variable‐wettability surfaces. 相似文献
9.
No school is an island; it is a part of a continuum or a pipeline of institutions which together form an educational pipeline through which groups of students pass. To turn a body of data into useful information for knowledge-based decision-making at any level, data must be collected, organised, analysed and reflected upon. The purpose of this paper is to discuss how schools and other educational institutions can not only collect better data but learn how to transform that data so that the information held within can be effectively shared among all stakeholders. This process will help to ensure that the school and the entire education system provide a more seamless and effective educational pipeline for students, and ultimately improve the quality of education delivered in the country as a whole. 相似文献
10.
Boaz Zion Pictiaw Chen Michael J McCarthy 《Journal of the science of food and agriculture》1995,67(4):423-429
The potential for utilizing nuclear magnetic resonance measurements for evaluating the quality of fresh prunes was investigated. In a 2 T magnetic flux density, the chemical shift between proton hydrogens of soluble solids and those of water is less than 100 Hz. The band width of the water resonance spectrum of fruits is relatively large and therefore it is difficult to resolve between the spectral peaks of water and soluble solids. Measurements with a 100 mm Birdcage coil failed to resolve between the resonance peaks of soluble solids and water. Good resolution was achieved with a 20 mm diameter Surface coil. Signals (free induction decay) of 30 sugar prunes were acquired, and the spectra were calculated. Tuning and matching the coil before each measurement were not necessary, and the results were better when the magnetic field was not shimmed. The ratio of the soluble solids peak height to the water peak height correlated well (r = 0.907) with the soluble solids content of the prunes, as estimated by a refractometer. 相似文献