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排序方式: 共有135条查询结果,搜索用时 15 毫秒
1.
In the reinforcement learning system, the agent obtains a positive reward, such as 1, when it achieves its goal. Positive
rewards are propagated around the goal area, and the agent gradually succeeds in reaching its goal. If you want to avoid certain
situations, such as dangerous places or poison, you might want to give a negative reward to the agent. However, in conventional
Q-learning, negative rewards are not propagated in more than one state. In this article, we propose a new way to propagate
negative rewards. This is a very simple and efficient technique for Q-learning. Finally, we show the results of computer simulations
and the effectiveness of the proposed method. 相似文献
2.
Tomohiro Fujii Jun Nishikawa Soichiro Fukuda Naoto Kubota Junzo Nojima Koichi Fujisawa Ryo Ogawa Atsushi Goto Koichi Hamabe Shinichi Hashimoto Aung Phyo Wai Hisashi Iizasa Hironori Yoshiyama Kohei Sakai Yutaka Suehiro Takahiro Yamasaki Taro Takami 《International journal of molecular sciences》2022,23(18)
DNA methylation of both viral and host DNA is one of the major mechanisms involved in the development of Epstein–Barr virus-associated gastric carcinoma (EBVaGC); thus, epigenetic treatment using demethylating agents would seem to be promising. We have verified the effect of , which was discovered by screening for demethylating agents. MC180295 inhibited cell growth of the EBVaGC cell lines YCCEL1 and SNU719 in a dose-dependent manner. In a cell cycle analysis, growth arrest and apoptosis were observed in both YCCEL1 and SNU719 cells treated with MC180295. MKN28 cells infected with EBV were sensitive to MC180295 and showed more significant inhibition of cell growth compared to controls without EBV infection. Serial analysis of gene expression analysis showed the expression of genes belonging to the role of BRCA1 in DNA damage response and cell cycle control chromosomal replication to be significantly reduced after MC180295 treatment. We confirmed with quantitative PCR that the expression levels of BRCA2, FANCM, RAD51, TOP2A, and CDC45 were significantly decreased by MC180295. LMP1 and BZLF1 are EBV genes with expression that is epigenetically regulated, and MC180295 could up-regulate their expression. In conclusion, MC180295 inhibited the growth of EBVaGC cells by suppressing DNA repair and the cell cycle. MC180295相似文献
3.
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Aishani Mazumder Chung Kim Nguyen Thiha Aung Mei Xian Low Md. Ataur Rahman Salvy P. Russo Sherif Abdulkader Tawfik Shifan Wang James Bullock Vaishnavi Krishnamurthi Nitu Syed Abhishek Ranjan Ali Zavabeti Irfan H. Abidi Xiangyang Guo Yongxiang Li Taimur Ahmed Torben Daeneke Akram Al-Hourani Sivacarendran Balendhran Sumeet Walia 《Advanced functional materials》2023,33(36):2303641
Miniaturization and energy consumption by computational systems remain major challenges to address. Optoelectronics based synaptic and light sensing provide an exciting platform for neuromorphic processing and vision applications offering several advantages. It is highly desirable to achieve single-element image sensors that allow reception of information and execution of in-memory computing processes while maintaining memory for much longer durations without the need for frequent electrical or optical rehearsals. In this work, ultra-thin (<3 nm) doped indium oxide (In2O3) layers are engineered to demonstrate a monolithic two-terminal ultraviolet (UV) sensing and processing system with long optical state retention operating at 50 mV. This endows features of several conductance states within the persistent photocurrent window that are harnessed to show learning capabilities and significantly reduce the number of rehearsals. The atomically thin sheets are implemented as a focal plane array (FPA) for UV spectrum based proof-of-concept vision system capable of pattern recognition and memorization required for imaging and detection applications. This integrated light sensing and memory system is deployed to illustrate capabilities for real-time, in-sensor memorization, and recognition tasks. This study provides an important template to engineer miniaturized and low operating voltage neuromorphic platforms across the light spectrum based on application demand. 相似文献
5.
Ko A.J. Myers B.A. Coblenz M.J. Aung H.H. 《IEEE transactions on pattern analysis and machine intelligence》2006,32(12):971-987
Much of software developers' time is spent understanding unfamiliar code. To better understand how developers gain this understanding and how software development environments might be involved, a study was performed in which developers were given an unfamiliar program and asked to work on two debugging tasks and three enhancement tasks for 70 minutes. The study found that developers interleaved three activities. They began by searching for relevant code both manually and using search tools; however, they based their searches on limited and misrepresentative cues in the code, environment, and executing program, often leading to failed searches. When developers found relevant code, they followed its incoming and outgoing dependencies, often returning to it and navigating its other dependencies; while doing so, however, Eclipse's navigational tools caused significant overhead. Developers collected code and other information that they believed would be necessary to edit, duplicate, or otherwise refer to later by encoding it in the interactive state of Eclipse's package explorer, file tabs, and scroll bars. However, developers lost track of relevant code as these interfaces were used for other tasks, and developers were forced to find it again. These issues caused developers to spend, on average, 35 percent of their time performing the mechanics of navigation within and between source files. These observations suggest a new model of program understanding grounded in theories of information foraging and suggest ideas for tools that help developers seek, relate, and collect information in a more effective and explicit manner 相似文献
6.
Jit Biswas Andrei Tolstikov Maniyeri Jayachandran Victor Foo Aung Aung Phyo Wai Clifton Phua Weimin Huang Louis Shue Kavitha Gopalakrishnan Jer-En Lee Philip Yap 《电信纪事》2010,65(9-10):505-521
Monitoring and timely intervention are extremely important in the continuous management of health and wellness among all segments of the population, but particularly among those with mild dementia. In relation to this, we prescribe three design principles for the construction of services and applications. These are ambient intelligence, service continuity, and micro-context. In this paper, we provide three exemplars from our research and development activities that illustrate the use of these design principles in the construction of services and applications. All the applications are drawn from the field of care for mild dementia patients in their living quarters. 相似文献
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8.
This study estimated the dietary intakes of 25 pairs of Japanese children and their parents to 12 toxic and essential trace elements using 7-day duplicate diet composites. The estimated intakes of lead (children = 5.34 microg day-1, adults = 6.74 microg day-1) and tin (162 and 152 microg day-1) were below tolerable limits, but large difference in aluminium intakes (7.32 and 12.1 mg day-1) among the subjects warranted further investigations. Intakes of cadmium in both children and adults (13.2 and 15.9 microg day-1) were high, but a low uranium (U) intake was observed (0.593 and 0.587 microg day-1). Intakes of copper (567 and 784 microg day-1), manganese (1.56 and 2.72 mg day-1), zinc (4.93 and 6.75 mg day-1), and molybdenum (103 and 131 microg day-1) were close to the recommended values. Concentrations of chromium, nickel and selenium were lower than the detection limits in most cases. 相似文献
9.
S Thein MM Aung TN Shwe M Aye A Zaw K Aye KM Aye J Aaskov 《Canadian Metallurgical Quarterly》1997,56(5):566-572
Despite a growing body of evidence predominantly, but not exclusively, from Thailand suggesting that the risk of developing dengue shock syndrome (DSS) is greatest following an anamnestic dengue infection, particularly if the most recent infection was with dengue 2 virus, there continues to be debate about the justification for these claims. This report describes a five-year, prospective study in two townships (suburbs) in Yangon (Rangoon) Myanmar (Burma) in which attempts were made to confirm the data from an earlier prospective study in Thailand and to address some of the criticism of earlier studies. This investigation found the incidence of anamnestic dengue infections in DSS patients to be significantly higher than in the community from which they were drawn and a significantly higher risk of developing DSS following an anamnestic infection (particularly with dengue 2 virus) than following a primary infection with any serotype. 相似文献
10.