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排序方式: 共有166条查询结果,搜索用时 0 毫秒
1.
MB Heyman JM LaBerge KA Somberg P Rosenthal C Mudge EJ Ring JD Snyder 《Canadian Metallurgical Quarterly》1997,131(6):914-919
The transjugular intrahepatic portosystemic shunt procedure is an accepted treatment for adults with complications of portal hypertension. We performed a retrospective review of all pediatric TIPS placements performed at the University of California, San Francisco between 1990 and 1996. Twelve procedures were attempted in nine children, with a mean age (+/- SD) of 9.4 +/- 3.9 years (range, 5 to 15 years) and a mean weight of 31 +/- 18 kg (range, 16 to 70 kg). The indications for TIPS placement were portal hypertension complicated by chronic variceal hemorrhage not controlled with sclerotherapy (n = 7) and hypersplenism with thrombocytopenia (n = 2). TIPS placement was successfully completed initially in seven of nine (78%) patients. Unfavorable vascular anatomy was the cause of failure in two cases. The seven patients who underwent successful TIPS placement were followed up for an average of 136 days (range, 1 to 800 days); two still have patent shunts, three underwent liver transplantation, one had a splenorenal shunt after stenosis, and one died of underlying liver disease. Variceal bleeding was controlled in four of five patients who successfully underwent TIPS placement. Shunt occlusion occurred in four patients; patency was restored by transjugular shunt revision in three, and a splenorenal shunt was performed in one. 相似文献
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Heyman JS 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》1989,36(6):581-586
The complexity of modern NDE (nondestructive evaluation) arises from four main factors: quantitative measurement, science, physical models for computational analysis, realistic interfacing with engineering decisions, and direct access to management priorities. Recent advances in the four factors of NDE are addressed. Physical models of acoustic propagation are presented that have led to the development of measurement technologies advancing the ability to assure that materials and structures will perform a design. In addition, a brief discussion is given of current research for future mission needs such as smart structures that sense their own health. Such advances permit projects to integrate design for inspection into their plans, bringing NDE into engineering and management priorities. The measurement focus is on ultrasonics with generous case examples. Problem solutions highlighted include critical stress in fasteners, residual stress in steel, NDE laminography, and solid rocket motor NDE. 相似文献
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Ira Michael Heyman 《Journal of the American Planning Association. American Planning Association》2013,79(3):247-254
Population projections for subcounty areas often are made by extrapolating past population trends. Although more sophisticated methods exist and population extrapolations long have been criticized for their weak theoretical foundations, they remain an extremely popular planning tool in part because constraints of data, time, funds, and expertise make the more sophisticated methods infeasible. The objective of this research was to document the level of accuracy of a number of commonly used extrapolative methods and, thereby, to offer suggestions for their use. For example, exponential extrapolation was found to be most accurate for rapidly growing or declining areas, whereas linear extrapolation was most accurate for moderately growing areas. More than thirty-five hundred simulated population projections for 1960 and 1970 were made for most of the methods being tested. Then the simulated projections were compared to the actual populations to measure percentage errors and tendencies to over- or underestimate. The results indicate that extrapolative methods may yield sufficiently accurate projections for many planning purposes. 相似文献
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P McLaughlin AJ Grillo-López BK Link R Levy MS Czuczman ME Williams MR Heyman I Bence-Bruckler CA White F Cabanillas V Jain AD Ho J Lister K Wey D Shen BK Dallaire 《Canadian Metallurgical Quarterly》1998,16(8):2825-2833
PURPOSE: The CD20 antigen is expressed on more than 90% of B-cell lymphomas. It is appealing for targeted therapy, because it does not shed or modulate. A chimeric monoclonal antibody more effectively mediates host effector functions and is itself less immunogenic than are murine antibodies. PATIENTS AND METHODS: This was a multiinstitutional trial of the chimeric anti-CD20 antibody, IDEC-C2B8. Patients with relapsed low grade or follicular lymphoma received an outpatient treatment course of IDEC-C2B8 375 mg/m2 intravenously weekly for four doses. RESULTS: From 31 centers, 166 patients were entered. Of this intent-to-treat group, 48% responded. With a median follow-up duration of 11.8 months, the projected median time to progression for responders is 13.0 months. Serum antibody levels were sustained longer after the fourth infusion than after the first, and were higher in responders and in patients with lower tumor burden. The majority of adverse events occurred during the first infusion and were grade 1 or 2; fever and chills were the most common events. Only 12% of patients had grade 3 and 3% grade 4 toxicities. A human antichimeric antibody was detected in only one patient. CONCLUSION: The response rate of 48% with IDEC-C2B8 is comparable to results with single-agent cytotoxic chemotherapy. Toxicity was mild. Attention needs to be paid to the rate of antibody infusion, with titration according to toxicity. Further investigation of this agent is warranted, including its use in conjunction with standard chemotherapy. 相似文献
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The present study investigates children's capacity to understand traits in a psychologically meaningful way. Participants included 18 individuals in each of 4 age groups: kindergarten (ages 5-6), 2nd grade (ages 7-8), 5th grade (ages 10-11), and adult. They heard a series of 6 short stories in which a main character performs an action based on a particular motive (positive, negative, or incidental) that results in either a positive or a negative emotional consequence for another character. Participants evaluated each main character and predicted the character's behavior and mental states in different social contexts. Participants in all age groups, even the 5- to 6-year-olds, made trait inferences that were influenced by motive information. These results provide evidence that young children are capable of more sophisticated reasoning about traits than has been suggested previously. 相似文献
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Griselda Deelstra Ahmed Ezzine Dries Heyman Michèle Vanmaele 《Computational Economics》2007,29(2):139-149
This paper studies a strategy that minimizes the Value-at-Risk (VaR) of a position in a zero-coupon bond by buying a percentage
of a put option, subject to a fixed budget available for hedging. We elaborate a formula for determining the optimal strike
price for this put option in case of a Vasicek stochastic interest rate model. We demonstrate the relevance of searching the
optimal strike price, since moving away from the optimum implies a loss, either due to an increased VaR or due to an increased
hedging expenditure. In this way, we extend the results of [Ahn, Boudoukh, Richardson, and Whitelaw (1999). Journal of Finance, 54, 359–375] who minimize VaR for a position in a share. In addition, we look at the alternative risk measure Tail Value-at-Risk. 相似文献
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Yael Abarbanel-Vinov Neta Aizenbud-Reshef Ilan Beer Cindy Eisner Daniel Geist Tamir Heyman Iris Reuveni Eran Rippel Irit Shitsevalov Yaron Wolfsthal Tali Yatzkar-Haham 《Formal Methods in System Design》2001,19(1):35-44
We examine IBM's exploitation of formal verification using RuleBase—a formal verification tool developed by the IBM Haifa Research Laboratory. The goal of the paper is methodological. We identify an integrated methodology for the deployment of formal verification which involves three complementary modes: architectural verification, block-level verification, and design exploration. 相似文献