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1.
The time delay experiment proposed by I.I. Shapiro in 1964 and conducted in the seventies was the most precise experiment
of general relativity until that time. Further experimentation has improved the accuracy level of both the time delay and
the light deflection experiments. A simulation model is proposed that involves only a simple mass and time transformation
factor involving velocity of light. The light deflection and the time delay experiments are numerically simulated using this
model that does not use the general relativistic equations. The computed values presented in this paper compare well with
recent levels of accuracy of their respective experimental results. 相似文献
2.
We present two new variants of Schur complement domain decompositionpreconditioners suitable for 2D anisotropic problems. Thesevariants are based on adaptations of the probing idea, describedby Chan et al (1992 Fifth Int. Symp. on Domain DecompositionMethods for Partial Differential Equations, Philadelphia: SIAM,pp 236-249), used in conjunction with a coarse grid approximationas introduced by Bramble et al (1986 Math. Comput. 47, 103-134).The new methods are specifically designed for situations wherethe coupling between neighbouring interfaces is stronger thanthe coupling within an interface. Taking into account this strongcoupling, one variant uses a multicolour probing technique toavoid distortion in the probe approximations that appear whenusing the method proposed by Chan et al. The second techniqueuses additional probe matrices to approximate not only the couplingwithin the interfaces but also the coupling between interfacepoints across the subdomains. This latter procedure looks somewhatlike an alternating line relaxation method for anisotropic problems,see Brandt (1977 Math. Comput.. 31, 333-390). To assess therelevance of the new preconditioners, we compare their numericalbehaviour with well known robust preconditioners such as thebalanced Neumann-Neumann method proposed by Mandel (1993 Commun.Numer. Methods Eng.. 9, 233-241). 相似文献
3.
The ‘anomalous perihelion precession’ of Mercury, announced by Le Verrier in 1859, was a highly controversial topic for more
than half a century and invoked many alternative theories until 1916, when Einstein presented his theory of general relativity
as an alternative theory of gravitation and showed perihelion precession to be one of its potential manifestations. As perihelion
precession was a directly derived result of the full General Theory and not just the Equivalence Principle, Einstein viewed
it as the most critical test of his theory. This paper presents the computed value of the anomalous perihelion precession
of Mercury's orbit using a new relativistic simulation model that employs a simple transformation factor for mass and time,
proposed in an earlier paper. This computed value compares well with the prediction of general relativity and is, also, in
complete agreement with the observed value within its range of uncertainty. No general relativistic equations have been used
for computing the results presented in this paper. 相似文献
4.
5.
In this study, we developed a strategy to determine atto- and femtomolar amounts of metal ions in lysates and mineralizates of cells (human non-small-cell lung carcinoma (NSCLC, A549) and normal lung (MRC-5)) exposed to cytotoxic metallo-drugs: cisplatin and auranofin at concentrations close to the half-maximal inhibitory drug concentrations (IC50). The developed strategy combines data obtained using biological and chemical approaches. Cell density was determined using two independent cell staining assays using trypan blue, calcein AM/propidium iodide. Metal concentrations in lysed and mineralized cells were established employing a mass spectrometer with inductively coupled plasma (ICP-MS) and equipped with a cross-flow nebulizer working in aspiration mode. It allowed for detecting of less than 1 fg of metal per cell. To decrease the required amount of sample material (from 1.5 mL to ~100 µL) without loss of sensitivity, the sample was introduced as a narrow band into a constant stream of liquid (flow-injection analysis). It was noticed that the selectivity of cisplatin accumulation by cells depends on the incubation time. This complex is accumulated by cells at a lower efficiency than auranofin and is found primarily in the lysate representing the cytosol. In contrast, auranofin interacts with water-insoluble compounds. Despite their different mechanism of action, both metallo-drugs increased the accumulation of transition metal ions responsible for oxidative stress. 相似文献
6.
Satheeshmanikandan RS Thappali Kanthikiran VS Varanasi Sridhar Veeraraghavan Swaroop Kumar VS Vakkalanka Mukkanti K 《Journal of mass spectrometry : JMS》2012,47(12):1612-1619
A sensitive and reliable high‐performance liquid chromatography–mass spectrometry (LC–MS/MS) was developed and validated for simultaneous quantification IC87114, roflumilast (RFM), and its active metabolite roflumilast N‐oxide (RFN) using tolbutamide as an internal standard. The analytes were extracted by using liquid–liquid extraction and separated on a reverse phase C18 column (50 mm × 3 mm i.d., 4.6 µ) using methanol: 2 mM ammonium acetate buffer, pH 4.0 as mobile phase at a flow rate 1 mL/min in gradient mode. Selective reaction monitoring was performed using the transitions m/z 398.3 > 145.9, 403.1 >186.9, 419.1 > 187.0 and 271.1 > 155.0 to quantify quantification IC87114, RFM, RFN and tolbutamide, respectively. The method was validated over the concentration range of 0.1–60 ng.mL?1 for RFM and RFN and 6 to 2980 ng.mL?1 for IC87114. Intra‐ and inter‐day accuracy and precision of validated method were within the acceptable limits of <15% at all concentrations. Coefficients of correlation (r2) for the calibration curves were >0.99 for all analytes. The quantitation method was successfully applied for simultaneous estimation of IC87114, RFM and RFN in a pharmacokinetic drug–drug interaction study in Wistar rats. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
7.
Munshi G Mustafa Sudhir Raniwala T Awes B Rai RS Bhalerao JG Contreras RV Gavai SK Ghosh P Jaikumar GC Mishra AP Mishra H Mishra B Mohanty J Nayak J-Y Ollitrault SC Phatak L Ramello R Ray PK Sahu AM Srivastava DK Srivastava VK Tiwari 《Pramana》2006,67(5):961-981
This is the report of Heavy Ion Physics and Quark-Gluon Plasma at WHEPP-09 which was part of Working Group-4. Discussion and
work on some aspects of quark-gluon plasma believed to have created in heavy-ion collisions and in early Universe are reported. 相似文献
8.
K. Jakubczak T. Mocek B. Rus J. Polan J. Hrebicek M. Sawicka P. Sikocinski J. Sobota T. Fort L. Pina 《Opto-Electronics Review》2011,19(2):169-175
We present results on development and experimental implementation of a 1-kHz, coherent extreme ultraviolet (XUV) radia- tion
source based on high-order harmonic generation of the femtosecond, near-infrared laser pulses produced by the titanium-doped
sapphire laser system (35 fs, 1.2 mJ, 810 nm) at the Institute of Physics AS CR / PALS Centre. The source comprises a low-density
static gas cell filled with a conversion medium, typically argon. The comprehensive optimization of the XUV harmonic source
has been performed with respect to major parameters such as gas pressure in the cell, cell length, position of the focus of
the driving laser field with respect to the gas cell position, size of the driving near-infrared laser beam, chirp of the
femtosecond pulse, and the focal length of the lens deployed in the experimental setup. Harmonic spectra were recorded using
an XUV transmission grating spectrometer developed specifically for this purpose. Detailed characterization of the XUV source
has been performed including measurement of the XUV beam profile, M2 parameter of the beam, absolute energy, and spatial coherence. 相似文献
9.
Cieślak Katarzyna Gańczyk-Specjalska Katarzyna Drożdżewska-Szymańska Katarzyna Królikowska Marta Jakubczak Marcin 《Journal of Thermal Analysis and Calorimetry》2022,147(13):7421-7430
Journal of Thermal Analysis and Calorimetry - Examinations of two-component mixtures, namely: triphenylamine?+?centralite I (TPA?+?CI) and... 相似文献
10.
T. Mocek B. Rus M. Kozlová J. Polan P. Homer K. Jakubczak M. Stupka D. Snopek J. Nejdl M. H. Edwards D. S. Whittaker G. J. Tallents P. Mistry G. J. Pert N. Booth Z. Zhai M. Fajardo P. Zeitoun J. Chalupsky V. Hájková L. Juha 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2009,54(2):439-444
An overview of recent advances in applications of currently the most energetic X-ray laser at 21 nm is given. The unique parameters
of this half-cavity based X-ray laser such as record output energy of 10 mJ, highly symmetric beam, robustness and reproducibility,
have made it possible to carry out a number of multidisciplinary scientific projects featuring novel applications of intense
coherent X-ray radiation. Selected results obtained in these experiments are reviewed, including X-ray laser probing of dense
plasmas, measurements of transmission of focused soft X-ray radiation at intensities of up to 1012 W cm-2, measurements of infrared laser ablation rates of thin foils, and ablative microstructuring of solids. 相似文献