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Environmental Impacts on Spiking Properties in Hodgkin-Huxley Neuron with Direct Current Stimulus 下载免费PDF全文
Based on the well accepted Hodgkin-Huxley neuron model, the neuronal intrinsic excitability is studied when the neuron is subject to varying environmental temperatures, the typical impact for its regulating ways. With computer simulation, it is found that altering environmental temperature can improve or inhibit the neuronal intrinsic excitability so as to influence the neuronal spiking properties. The impacts from environmental factors can be understood that,the neuronal spiking threshold is essentially influenced by the fluctuations in the environment. With the environmental temperature varying, burst spiking is realized for the neuronal membrane voltage because of the environment-dependent spiking threshold. This burst induced by changes in spiking threshold is different from that excited by input currents or other stimulus. 相似文献
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文章讨论了稳定涡旋电场中导体上的电压,并把该情况及似稳条件下导体上的电势电势差与静电场中的电势、电势差作了比较。结果表明:只存在静电场时,空间任一点有电势,两点间有电势差;存在涡旋电场时,在一定条件下(形成稳定电流和似稳电流时)在导体上任一点有电势,只在由导体连接着的两点间有电势差。当电场为只由静止电荷激发的静电场,此时一点的电势值与零点的选择有关,电势差与积分路径无关;当电场为全部电场中的保守场部分时,一点的电势值与零点的选择有关,电势差也与积分路径无关。两点间电势差是单位正电荷从一点经任意路径移到另一点时外力克服静电力做功而增加的能量,即静电势能的增量;两点间电势差是单位正电荷从导体上任一点经导体中的任意路径移到另一点时获得的(净)能量,是外力所做的功除去发热剩余的能量,数值上恰等于静电势能的增量。 相似文献
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The hydration structure properties of different alkali metal ions with eight water molecules and potassium ions with different numbers of water molecules are studied using the mixed density functional theory, B3LYP, with 6-3110 basis set. The hydration structures are obtained from structure optimization and the optimum numbers of water molecules in the innermost hydration shell for the alkali metal ions are found. Some useful information about the ion channel selectivity is presented. 相似文献
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We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^+ channels, determine the selectivity of the channel. 相似文献
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It is well known that the strong coupling can synchronize a network of nonlinear oscillators. Synchronization provides the basis of the remarkable computational performance of the brain. In this paper the FitzHugh-Nagumo neuron network is constructed. The dependence of the synchronization on the coupling strength, the noise intensity and the size of the neuron network has been discussed. The results indicate that the coupling among neurons works to improve the synchronization, and noise increases the neuron random dynamics and the local fluctuations; the larger the size of network, the worse the synchronization. The dependence of the synchronization on the strength of the electric synapse coupling and chemical synapse coupling has also been discussed, which proves that electric synapse coupling can enhance the synchronization of the neuron network largely. 相似文献
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It has been proved recently that the spike timing can play an important role in
information transmission, so in this paper we develop a network with N-unit
FitzHugh--Nagumo neurons coupled by gap junctions and discuss the dependence of the
spike timing precision on synaptic coupling strength, the noise intensity and the
size of the neuron ensemble. The calculated results show that the spike timing
precision decreases as the noise intensity increases; and the ensemble spike timing
precision increases with coupling strength increasing. The electric synapse coupling
has a more important effect on the spike timing precision than the chemical synapse
coupling. 相似文献
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结合钾离子通道的三维精细结构,从第一性原理出发,在充分考虑电子相互作用的基础上,采用密度泛函方法计算得到了钾通道的位能曲线;以此作为钾通道布朗动力学模型的力场参数,应用布朗动力学方法研究了钾离子通道的动力学特征,得到了一些有益的结果。In the paper, based on the first principle and the X-ray structure of the potassium ion channel, the potential curve is calculated by the density functional theory. And forced by the potential, the dynamical properties of K channels are also studied. 相似文献
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