干扰素的功能表达机理——2′-5′三腺苷酸对巨噬细胞的激活对甲胎蛋白的对抗作用

本试验结果表明:1.2′-5′三腺苷酸(2′-5′P_3A_3)有激活多种来源(包括人)巨噬细胞的吞噬作用,说明2′-5′P_3A_3对巨噬细胞的激活作用具有普遍意义。2.甲胎蛋白(AFP)能抑制巨噬细胞的吞噬功能,可能对肝癌的发生有一定的作用。本工作证实2′-5′P_3A_3能抵消AFP对巨噬细胞的抑制作用。3.关于2′-5′P_3A_3生物功能的研究,过去都要用CaCl_2等方法将它引入细胞,这对临床应用是不实际的。本文不使用CaC国_2等方法,2′-5′P_3A_3即能激活巨噬细胞。     

MECHANISM OF INTERFERON ACTION——ACTIVATION OF MACROPHAGES AND ANTAGONISM TO a-FETO-PROTEIN BY _(ppp)A_(2'p5')A_(2'p5')A

_(ppp)A_(2'p),'A_(2'p,)'A(2'-5'P_3A_3) activates macrophages and increases the phagocytosis of macrophages from different species including human beings. This indicates that the activation of macrophages may be a general action of 2'-5'P_3A_3. This discovery broadens the effect of 2'-5'P_3A_3 beyond the antiviral field.α-Feto-protein (AFP) inhibits the phagocytosis of macrophages and may be involved in the development of hepatoma. Data presented here show that 2'-5'P_3A_3 can antagonize this suppressive effect of AFP.Methods used so far for introducing 2'-5'P_3A_3 into the cells were made with the aid of CaCl_2, etc. under conditions which may not be the same as those used clinically. It was found that 2'-5'P_3A_3 can develop its biological effect without the aid of CaCl_2, etc.     

一种新颖的取样光纤光栅振幅版的研制

提出了一种新颖的用于制作取样光纤光栅的取样振幅版的设计方案,其特点是具有渐变的取样周期和不变的占空比,利用这种振幅版可以简单灵活地制作出反射峰波长间隔不同的取样光栅梳状滤波器,有利于提高取样光栅的制作灵活性并降低成本.对这种方法可能存在的不足也进行了分析.利用制作出的取样光栅,基于全光纤结构实现了具有游标尺式波长调谐机理的可选波长光纤激光器. 关键词： 取样光纤光栅 梳状滤波器 可选波长光纤激光器 振幅版     

相位修正的耦合模理论用于计算光纤Bragg光栅法布里-珀罗腔透射谱

基于光纤Bragg光栅(FBG)反射复振幅相移对FBG法布里-珀罗腔透射谱的影响,分析了传统耦合模理论计算均匀FBG反射复振幅相移产生误差的原因.引入折射率分布初始相位参数描述FBG折射率分布纵向的微小偏移,用真实的反透射系数代替简明形式的反透射系数,对传统耦合模理论进行了修正,增加了与折射率分布初始相位参数有关而与波长无关的相位因子.在此基础上进一步对计算非均匀FBG的传输矩阵法的相位进行了修正.修正后的快速计算结果用于FBG法布里-珀罗腔透射谱的计算,可反映折射率分布初始相位参数对透射峰波长位置的影响,与Rouard 算法及实验值均有较好的一致性. 关键词： 光纤Bragg 光栅 法布里-珀罗腔 耦合模理论     

农药丁吡吗啉与腐殖酸作用机理探讨

探讨农药丁吡吗啉与腐殖酸的作用机理, 可进一步了解农药在土壤中腐殖酸催化下降解的行为过程。将市售腐殖酸进行逐级分离,获得黄腐酸、棕腐酸和黑腐酸的固态或溶液状态,而后分别与农药丁吡吗啉进行作用,利用红外,荧光两种分析方法对其作用机理进行了解释。结果表明,三组分与丁吡吗啉之间广泛存在范德华力、次级键等弱作用力。黄腐酸与丁吡吗啉之间存在氢键和电荷转移吸附等作用力,棕腐酸与丁吡吗啉存在电荷转移吸附等作用力,黑腐酸与丁吡吗啉之间的作用力最弱,即依照黄腐酸、棕腐酸、黑腐酸三组分平均分子量依次递增的顺序,与农药丁吡吗啉之间的作用力依次降低。     

Temperature or strain induced adjustable-chirp characteristics of uniform fibre grating with tapered metal coating

Temperature and strain characteristics of uniform fibre grating with tapered metal coatings have been analysed theoretically, by which adjustable chirp characteristics of such gratings are shown. Electroplating is adopted to fabricate such gratings, and the tapered metal coating is obtained by gradually drawing the fibre grating out of the solution during the process of electroplating. The gradually changing cross-sectional area of the metal coating is calculated by a newly suggested numerical method. By combining the theoretical and numerical simulation analyses, the gratings' characteristics are given at various temperatures and strains. The results obtained using such a method are also testified by experiments.     

基于环形芯光纤的超低差分模式增益涡旋光纤放大器

提出了一种基于环形芯铒离子部分掺杂光纤的涡旋光纤放大器。针对该掺铒光纤的放大特性,研究了光纤长度、掺铒浓度与抽运功率对信号模式增益特性的影响。研究结果表明,该光纤放大器能够支持22个轨道角动量模式稳定传输,且C波段(1530~1565 nm)所有信号模式增益大于23 dB,信噪比高于27 dB,差分模式增益小于0.015 dB。所提出的基于环形芯光纤的涡旋光纤放大器具有支持轨道角动量模式数量多、差分模式增益低、信噪比高的优势,对于OAM复用长距离传输系统中的在线放大具有重要参考价值。     

一种新颖的取样光纤光栅振幅版的研制

提出了一种新颖的用于制作取样光纤光栅的取样振幅版的设计方案，其特点是具有渐变的取样周期和不变的占空比，利用这种振幅版可以简单灵活地制作出反射峰波长间隔不同的取样光栅梳状滤波器，有利于提高取样光栅的制作灵活性并降低成本.对这种方法可能存在的不足也进行了分析.利用制作出的取样光栅，基于全光纤结构实现了具有游标尺式波长调谐机理的可选波长光纤激光器.     

波长可调谐取样光纤光栅激光器的输出特性研究

建立了具有两个取样周期略有不同的取样光纤光栅反射镜的Vernier波长调谐机制的光纤分布布拉格反射式激光器的数值仿真模型,对激光器的输出特性进行了分析. 研究了激光器输出特性随着激光器前后光栅反射镜波长以及前后光栅反射镜反射率的变化关系. 提出了对两取样光栅反射率的优化配置方案,可以使输出激光的边模抑制比有所提高;同时对波长调节方式也进行了探讨;进行了实验研究. 关键词： 取样光纤光栅 光纤激光器 波长可调谐激光器     

Theoretical and experimental investigation of the mode-spacing of fiber Bragg grating Fabry-Perot cavity

The mode-spacing of the fiber Bragg grating Fabry-Perot （FBG F-P） cavity is calculated by using the effective cavity length which contains the effective length of the FBG. The expression of the effective length, defined by using the phase-time delay, is obtained and simplified as a function of the peak reflectivity at the Bragg wavelength, the band edges, and the first zero-reflectivity wavelength. The effective length is discussed from the energy penetration depth point of view. Three FBG F-P cavities are fabricated in order to validate the effective length approach. The experimental data fits well with the theoretical predictions. The limitation of this method is also pointed out and the improved approach is proposed.