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排序方式: 共有86条查询结果,搜索用时 15 毫秒
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Metabolic Brain Disease - The most common form of the disease caused by Toxoplasma gondii (T. gondii) is latent toxoplasmosis due to the formation of tissue cysts in various organs, such... 相似文献
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H. Rajaian S. Nazifi K. Nayeri F. Saberi Afshar F. Ehteshami 《Comparative clinical pathology》2008,17(1):13-16
To examine the clinical pathology of halothane in ruminants, five healthy fat-tailed sheep aged 1 to 2 years weighing 35 to
55 kg and four healthy calves aged 2 to 4 months weighing 30 to 65 kg were used. Anesthesia was induced and maintained by
halothane using a closed-circuit anesthetic machine. The average induction time was found to be around 5 min in sheep and
calves. Hematological studies indicated that there was an increase in neutrophils, significantly different only in sheep at
2 h after anesthesia, and a moderate decrease in lymphocytes. Total white blood cell counts slightly increased during anesthesia.
Packed cell volume (PCV) was significantly higher 1 day and 1 week after anesthesia in sheep, but not in calves. The pre-anesthetic
serum cholesterol level was around three times greater in calves compared to its level in sheep. However, there was a significant
decline in the cholesterol concentration in sheep during 2 h anesthesia. Creatine phosphokinase (CPK) was moderately increased
after 2 h anesthesia in both sheep and calves. Moreover, ALT, AST, and ALP were slightly increased 1 day post-anesthesia.
Liver biopsies taken 2 weeks after anesthesia were not indicative of any specific pathologic change in sheep or calves. There
were no prominent alterations in other biochemical parameters during or after anesthesia. Therefore, it is generally concluded
that halothane can be used to induce and maintain general anesthesia in sheep and calves with the least adverse effects on
clinical laboratory parameters. 相似文献
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Ramin Bagheri Nejad Ramak Yahyaraeyat Ali Es‐haghi Bahar Nayeri Fasaei Taghi Zahraei Salehi 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2019,127(12):797-804
Brucellosis is a worldwide bacterial zoonosis caused by Brucella spp. No approved vaccine is available for human use against the disease. In this study, outer membrane vesicles (OMVs) from a Brucella melitensis biovar 1 human isolate obtained in Iran were used to immunize BALB/c mice (n = 12) by 2 intramuscular injections with a 2‐week interval. Another group of 12 mice was used as non‐vaccinated controls. Two weeks after the last vaccination, six mice of each group were sacrificed, and proliferation and interferon gamma (IFNγ) production responses of their splenocytes were evaluated following in vitro stimulation with killed Brucella cells. The other mice were challenged with the virulent B. melitensis isolate. Two weeks later, mice were killed and spleens were cultured to determine the number of the challenge strain. The results showed proliferative response and IFNγ production of splenocytes from vaccinated mice (stimulation index: 2.18 ± 0.57, and 1519.35 ± 10.70 pg/mL, respectively) were significantly higher than those of control mice (stimulation index: 1.02 ± 0.02, and 210.01 ± 17.58 pg/mL, respectively). Numbers of the challenge strain in spleens of vaccinated mice were also significantly less than those in the controls with 1.6 units of protection. Our study revealed vaccination with OMVs of the B. melitensis isolate could induce specific immune responses and protection against infection in the mouse model suggesting their potential application for active immunization against brucellosis. 相似文献
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Afsaneh Amouei Mahmood Moosazadeh Tooran Nayeri chegeni Shahabeddin Sarvi Azadeh Mizani Mehdi Pourasghar Saeed Hosseini Teshnizi Zahra Hosseininejad Samira Dodangeh Abdolsattar Pagheh Amir Hossein Pourmand Ahmad Daryani 《Transboundary and Emerging Diseases》2020,67(5):1847-1860
The World Health Organization has reported an annual global suicide rate of 14.5 per 100,000 people. On the other hand, it is estimated that approximately one‐third of the global population are infected with Toxoplasma gondii (T. gondii) parasite. It is widely assumed that microbial pathogens, such as T. gondii, are probably associated with affective and behavioural modulation. The present article aimed to assess the proposed role of toxoplasmosis in raising the risk of suicidal ideation (SI) and suicide attempts (SA) using the available epidemiological data. Seven major electronic databases and the Internet search engine Google were searched for all the studies published between the 1st of January 1950 and 31st of October 2019. The heterogeneity and the risk of bias within and across studies were assessed. Following data extraction, pooled odds ratios (ORs) with 95% confidence interval (CI) across studies were calculated using the random‐effects models. A total number of 9,696 articles were screened and 27 studies were regarded as eligible in our systematic review (SI with five papers and 22 papers on SA). A significant association was detected between antibodies against T. gondii with TA (ORs = 1.57; 95% confidence interval [CI] 1.23–2.00, p = .000). Exploration of the association between T. gondii and SA yielded a positive effect of seropositivity for IgG antibodies but not IgM. Despite the limited number of studies, a statistical association was detected between suicidal behaviours and infection with latent T. gondii. 相似文献
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Nancy Birkner Sara Nayeri Babak Pashaei Mohammad Mahdi Najafpour William H. Casey Alexandra Navrotsky 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(22):8801-8806
Previous measurements show that calcium manganese oxide nanoparticles are better water oxidation catalysts than binary manganese oxides (Mn3O4, Mn2O3, and MnO2). The probable reasons for such enhancement involve a combination of factors: The calcium manganese oxide materials have a layered structure with considerable thermodynamic stability and a high surface area, their low surface energy suggests relatively loose binding of H2O on the internal and external surfaces, and they possess mixed-valent manganese with internal oxidation enthalpy independent of the Mn3+/Mn4+ ratio and much smaller in magnitude than the Mn2O3-MnO2 couple. These factors enhance catalytic ability by providing easy access for solutes and water to active sites and facile electron transfer between manganese in different oxidation states. 相似文献
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Hepatocyte growth factor is a better indicator of therapeutic response than C-reactive protein within the first day of treatment in pneumonia 总被引:1,自引:0,他引:1
Acute bacterial infectious diseases are mostly treated empirically at admission before the culture results are available. According to the risk for serious complications in the case of therapeutic failure, it is important to evaluate the therapy results and change to a more appropriate antibiotic regime as soon as possible. In the present study, 40 patients with X-ray-verified community-acquired pneumonia were examined and blood specimens were collected before and within 24 h of treatment. Body temperature, C-reactive protein (CRP) and hepatocyte growth factor (HGF) were investigated. Thirty-two patients received an appropriate initial antibiotic therapy regarding clinical outcome, but in 8 patients the treatment was changed because of therapy failure. Changes of HGF levels after 18-24 h of treatment could predict the therapeutic results accurately in 38 of 40 cases (sensitivity 100%, specificity 94%, positive likelihood ratio 16.0). HGF was significantly better to predict therapy outcome than CRP (p < 0.0001). 相似文献
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