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The influence of different levels of dietary fat on the incidence and growth of MNU-induced mammary carcinoma in rats 总被引:1,自引:0,他引:1
This study describes the influence of isocalorically fed diets (containing different amounts of fat) on tumor incidence and parameters of fat metabolism in female Sprague-Dawley rats. Comparisons are made between rats induced with methylnitrosourea (25 mg/kg body wt) and untreated controls (Group I). The animals received either control diets (3.9% fat by weight, Groups I and II) or fat-enriched diets (10.7%, Group III; 15.6%, Group IV; 21.4%, Group V) over a period of 180 days. At the termination of the experiment, intake of the diet containing 10.7% fat by weight (24% fat per total calories) was associated with the highest tumor incidence. Comparing the different diets, liver lipid concentrations in the individual groups increased with increasing dietary fat, whereas the total lipid in plasma decreased. During the feeding period, total lipid of the liver and plasma, and plasma cholesterol, increased in all groups, but triglycerides of plasma decreased. However, when plasma cholesterol and triglycerides were calculated as a relative amount of total lipid in plasma, cholesterol was found to be significantly decreased in Groups III and IV, and triglycerides were increased in Group III but decreased significantly in Groups I, II, and V at the end of the experiment. 相似文献
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Uur Koçer MD Nilgün Atakan MD Hasan Mete Aksoy MD Yigit Özer Tiftikcioglu MD Berna Aksoy MD Müzeyyen Astarci MD 《Dermatologic surgery》2003,29(3):291-293
BACKGROUND: Superficial lymphatic malformations are predominantly developmental malformations of infancy, but they may arise at any age. OBJECTIVE: To describe a patient with a late-onset superficial lymphatic malformation. METHODS: Case report and literature review. RESULTS: A 53-year-old woman was evaluated for a colored lesion that developed spontaneously on the anterior abdominal wall. The lesion was treated by surgical excision. Findings on histopathologic examination of the specimen were consistent with superficial lymphatic malformation. There was no recurrence of the lesion at 4 months after the operation. CONCLUSION: Superficial lymphatic malformations can develop in adults spontaneously without the presence of any predisposing condition. Because the majority of such late-onset malformations reported in the literature are localized lesions similar to the one in our patient, surgical removal with inclusion of subcutaneous tissue usually results in cure without recurrence. 相似文献
6.
Iatrogenic injuries to ureter, bladder and urethra during abdominal and pelvic operations 总被引:1,自引:0,他引:1
Ö Polat O. Gül Y. Aksoy I. Özbey A. Demirel Y. Bayraktar 《International urology and nephrology》1997,29(1):13-18
Abdominal and pelvic operations at Departments of Obstetrics and Gynaecology, and General Surgery play an important role in
ureteral, bladder and rarely urethral injuries.
Fifty-nine patients with iatrogenic ureteral, bladder and urethral injuries were treated at the Department of Urology, Atatürk
University Research Hospital, between 1985 and 1995. These injuries were urinary vaginal fistulas in 43 patients (vesicovaginal
33, ureterovaginal 7, urethrovaginal 2 and vesicovaginal plus urethrovaginal 1), ureteric ligation in 9, bladder laceration
in 7. These injuries were treated by different methods. All patients were followed up by intravenous urography (IVU) and urine
culture three months later.
It must be borne in mind that iatrogenic urinary tract injuries are not rare. Bladder and ureteral catheterization must be
performed to prevent these complications. 相似文献
7.
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection 总被引:6,自引:10,他引:6
Balaban B; Urman B; Sertac A; Alatas C; Aksoy S; Mercan R 《Human reproduction (Oxford, England)》1998,13(12):3431-3433
In this study, we compared the fertilization rate and embryo quality after
intracytoplasmic sperm injection (ICSI) as they relate to oocyte
morphology. A total of 654 ICSI cycles yielding 5903 metaphase II oocytes
were observed. The oocytes retrieved in these cycles were divided into (i)
normal oocytes, (ii) oocytes with extracytoplasmic abnormalities (dark zona
pellucida and large perivitelline space), (iii) oocytes with cytoplasmic
abnormalities (dark cytoplasm, granular cytoplasm, and refractile body),
(iv) oocytes with shape abnormalities, and (v) oocytes with more than one
abnormality (double and triple abnormalities). Intracytoplasmic vacuoles
and aggregates of smooth endoplasmic reticulum were not recorded
separately. The fertilization rate and quality of morphologically graded
embryos did not differ between the groups. There were 77 cycles where all
transferred embryos were derived from abnormal oocytes, and 164 cycles
where all embryos were derived from normal oocytes. These cycles were
studied further. The two groups were comparable regarding mean female age,
duration of infertility, duration of ovarian stimulation, number of
ampoules of gonadotrophin injected, and number of oocytes retrieved. Two
clinical pregnancy rates (44.4 versus 42.1%) and implantation rates per
embryo (10.3 versus 13.2%) were similar. In conclusion, in couples
undergoing ICSI, abnormal oocyte morphology is not associated with a
decreased fertilization rate or unfavourable embryo quality. Furthermore,
embryos derived from abnormal oocytes yield similar clinical pregnancy and
implantation rates when transferred compared with embryos derived from
normal oocytes.
相似文献
8.
Correlation of P-selectin and lipoprotein(a), and other lipid parameters in preeclampsia 总被引:1,自引:0,他引:1
Preeclampsia is a pregnancy specific disorder and is thought to be associated with generalized endothelial dysfunction. P-selectin,
an adhesion molecule, mediates the interaction of monocytes, platelets, and endothelial cells. Increased P-selectin levels
and altered lipid and lipoprotein metabolism were reported in preeclampsia and during pregnancy. In order to investigate
the relationship between serum P-selectin and lipoprotein(a), and other lipid parameters, 28 preeclampsia [13 severe (group
I) and 15 mild preeclampsia (group II), 15 healthy pregnant (group III) and 20 non-pregnant (group IV)] women were investigated.
Serum P-selectin, lipoprotein(a), total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured
and low-density lipoprotein cholesterol was derived. Serum P-selectin concentrations were consistently and significantly higher
in the severe preeclampsia group than in the mild preeclampsia, healthy pregnancy, and non-pregnant control groups (P<0.0001, for all). The mild preeclampsia group also had increased serum P-selectin concentrations compared with the healthy
pregnancy group and non-pregnant controls (P<0.05 and P<0.0001, respectively). Serum P-selectin and lipoprotein(a) levels revealed a significant and linear increase with the severity
of preeclampsia. There were also significant (in groups I and II) and borderline (in groups III and IV) correlations between
P-selectin and total cholesterol. The present study suggests that P-selectin may be an additional risk marker for preeclampsia,
and may be useful in distinguishing women with mild and severe preeclampsia and normal pregnancy.
Received: 9 November 2001 / Accepted: 6 February 2002 相似文献
9.
This study investigated the relationship between the antioxidant capacity of blood and the serum level of nitric oxide (NO) in patients with hepatic cirrhosis. The study included 20 patients with compensated cirrhosis (group I), 30 with decompensated cirrhosis (group II), and 30 healthy controls (group III). The serum levels of NO, albumin, bilirubin, and uric acid, and the erythrocyte activity of superoxide dismutase (SOD) were measured in all groups. The mean erythrocyte SOD activity (5.94 +/- 3.21 U/mg protein) and serum NO level (25.19 +/- 8.15 micromol/L) in group I were similar to those of controls (6.86 +/- 2.47 U/mg protein and 21.67 +/- 6.51 micromol/L, respectively). However, erythrocyte SOD activity in group II was significantly lower than in groups I and III and mean serum NO level was significantly higher in group II than in groups I and III. In regard to non-enzymatic antioxidants, the mean serum albumin level was lower and the mean serum total bilirubin level was higher in group II than in groups I and III. As expected, group I had higher mean serum total bilirubin level than the control group. Correlation analysis showed that erythrocyte SOD activity in cirrhotic patients was negatively correlated with their serum levels of NO. These results suggest that disturbances of antioxidative mechanisms may diminish hepatic resistance to oxidative stress, thereby contributing to the development of fibrogenesis. 相似文献
10.
Akman MA Erden HF Tosun SB Bayazit N Aksoy E Bahceci M 《Human reproduction (Oxford, England)》2001,16(5):868-870
The management of poor responders in IVF has always been a big problem. The ideal approach has yet to be formulated. In this study we aim to compare two alternative stimulation protocols. A total of 48 poor responder patients described from previous cycles were included and grouped into two: group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 microg s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3; group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration. While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance. The impact of these two regimens in ovarian stimulation of poor responders seem to be same and to establish these results further randomized studies with larger sample sizes are required. 相似文献