全文获取类型
收费全文 | 1904篇 |
免费 | 104篇 |
国内免费 | 14篇 |
学科分类
医药卫生 | 2022篇 |
出版年
2024年 | 3篇 |
2023年 | 11篇 |
2022年 | 27篇 |
2021年 | 39篇 |
2020年 | 20篇 |
2019年 | 36篇 |
2018年 | 43篇 |
2017年 | 24篇 |
2016年 | 51篇 |
2015年 | 36篇 |
2014年 | 59篇 |
2013年 | 59篇 |
2012年 | 123篇 |
2011年 | 144篇 |
2010年 | 88篇 |
2009年 | 52篇 |
2008年 | 100篇 |
2007年 | 133篇 |
2006年 | 123篇 |
2005年 | 126篇 |
2004年 | 128篇 |
2003年 | 108篇 |
2002年 | 140篇 |
2001年 | 24篇 |
2000年 | 20篇 |
1999年 | 34篇 |
1998年 | 27篇 |
1997年 | 27篇 |
1996年 | 21篇 |
1995年 | 18篇 |
1994年 | 17篇 |
1993年 | 12篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 16篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 6篇 |
1978年 | 9篇 |
1974年 | 8篇 |
1971年 | 3篇 |
1970年 | 2篇 |
排序方式: 共有2022条查询结果,搜索用时 15 毫秒
1.
Osamu Yokota Kuniaki Tsuchiya Yoshimasa Noguchi Hisamasa Akabane Hideki Ishizu Yukinobu Saito Haruhiko Akiyama 《Neuropathology》2007,27(6):539-550
We report a case of a 68‐year‐old right‐handed man with sporadic amyotrophic lateral sclerosis (ALS) and argyrophilic grain disease (AGD) having a 22‐month duration. His initial symptoms were dysarthria and swallowing difficulty at the age of 67. Subsequently bulbar palsy and pyramidal signs developed. His cognitive functions including face recognition, personality, and behavior were not changed compared with that of before the disease onset. However, magnetic resonance imaging disclosed severe right side‐predominant temporal atrophy. The neurological diagnosis was bulbar type ALS. Pathological examination disclosed histological evidence of ALS, including loss of Betz cells and lower motor neurons, corticospinal tract degeneration, and Bunina bodies. In addition, severe neuronal loss in the bilateral temporal cortex with an anterior gradient was found. Ubiquitin‐positive inclusions were encountered in the spinal anterior horn cells and hippocampal dentate gyrus, while few ubiquitin‐positive inclusions were noted in the affected temporal cortex. The amygdala, especially the basolateral nuclear group, was severely affected by neuronal loss with tissue rarefaction. Moderate neuronal loss was encountered in the parahippocampal gyrus, and to a lesser degree, in the ambient gyrus. Unexpectedly, many argyrophilic grains, coiled bodies, tau‐positive bush‐like astrocytes, pretangles, and ballooned neurons were found in the limbic system and temporal cortex. In the hippocampus, selective tau accumulation with minor neurofibrillary changes was observed in CA2 neurons. The present case suggests that (i) ALS and AGD do rarely coexist, and (ii) when ALS patients have severe temporal atrophy, not only ALS with dementia but also concurrent AGD should be considered in the differential diagnosis. 相似文献
2.
Hiroomi Murayama Masanobu Meda Ken Miyahara Yoshimasa Sakai Hajime Sakurai Hiroki Hasegawa Akemi Kawamura 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(3):91-97
Objective: We assessed the current role of preoperative and intraoperative autologous blood donation in pediatric open-heart surgery.
Methods: Group 1 consisted of 51 patients between 5 and 10 years old who underwent preoperative autologous blood donation. Group
2 consisted of 50 age-matched patients without preoperative donation as controls. Intraoperative donation was conducted in
both groups prior to cardiopulmonary bypass. We evaluated perioperative blood cell count, blood loss, and the need for homologous
blood products. Results: No serious complications occurred in preoperative or intraoperative donation. Total preoperative donation storage was 17.5±3.4
mL/kg. Intraoperative donation was 21.7 ±6.1 mL/kg in Group 1 and 12.8±4.0 mL/kg in Group 2 (p<0.001). On admission, serum
hemoglobin was lower in Group 1 (12.2±1.0 g/dL versus 13.6±1.6 g/dL, p<0.001) but returned postoperatively to the preoperative
value. It hovered at a depressed level in Group 2 (12.2±1.4 versus 10.2±1.1 g/dL, p<0.001). The homologous blood requirement
was significantly less in Group 1 than in Group 2 (0% versus 10%, p<0.05). Postoperative platelet counts showed similar curves,
and blood loss was not statistically significantly different between groups. Conclusion: Preoperative and intraoperative donations are safe and continue to contribute uniquely to blood conservation, providing
important options in comprehensive blood conservation programs in current pediatric open-heart surgery. 相似文献
3.
4.
Eichi Itadera Yoshimasa Miyake Yoichi Nakatsuka Hirofumi Akazawa Shigeru Mitani Kiyoshi Aoki 《Journal of orthopaedic science》1996,1(4):252-258
We report satisfactory results with a new operative treatment, conducted via an extensive anterolateral approach, involving
360 degree circumferential capsulotomy, for residual subluxation in congenital dislocation of the hip (CDH). Long-term radiographic
results of this procedure (group A) were compared retrospectively with the results of partial capsulotomy (group B), which
preserved the posteroinferior joint capsule. The mean center edge angle in group A (22.5°) was greater than that in group
B (16.0°). Satisfactory results were achieved in 11 of 15 hips (73%) (Severin class I or II) in group A, and in 5 of 12 hips
(42%) in group B. These results suggest that whole circumferential capsulotomy can remove obstacles to complete reduction,
and that acetabular development can be expected in hips reduced by the procedure, without the performance of innominate osteotomy.
We believe that our technique is a useful alternative for the treatment of residual subluxation in CDH. 相似文献
5.
Yoshimasa Mori Masakazu Takayasu Yoshio Suzuki Masato Shibuya Jun Yoshida Hiroyoshi Hidaka 《European journal of pharmacology》1997,320(2-3):183-186
The vasodilator effects of C-type natriuretic peptide (CNP) were investigated in isolated rat cerebral arterioles. CNP caused dose-dependent vasodilation, maximally by 10.0±2.2% at 10−6 M. The median effective concentration (EC50) was 5.2×10−10 M. In contrast, atrial natriuretic peptide and B-type natriuretic peptide, other members of the natriuretic peptide family, produced little or no vasodilation. Pretreatment with methylene blue (10−4 M) abolished CNP-induced vasodilation, whereas pretreatment with NG-monomethyl--arginine or indomethacin did not inhibit vasodilation. Thus, CNP is suggested to cause significant vasodilation in cerebral arterioles via a cyclic guanosine monophosphate-dependent mechanism. © 1997 Elsevier Science B.V. All rights reserved. 相似文献
6.
7.
Yoshimasa Matsuda Shinya Ono Yosuke Otake Shinya Handa Katsumi Kose Tomoyuki Haishi Shigeto Yamada Chikako Uwabe Kohei Shiota 《Magnetic resonance in medical sciences》2007,6(3):139-146
Using 4 and 8-channel super-parallel magnetic resonance (MR) microscopes with a horizontal bore 2.34T superconducting magnet developed for 3-dimensional MR microscopy of the large Kyoto Collection of Human Embryos, we acquired T(1)-weighted 3D images of 1204 embryos at a spatial resolution of (40 microm)(3) to (150 microm)(3) in about 2 years. Similarity of image contrast between the T(1)-weighted images and stained anatomical sections indicated that T(1)-weighted 3D images could be used for an anatomical 3D image database for human embryology. 相似文献
8.
单克隆抗体对溶组织内阿米巴吞噬红细胞的影响 总被引:1,自引:0,他引:1
用具有抗细胞膜活性和抗细胞核、胞浆活性的单克隆抗体3F7和4G6与致病性溶组织内阿米巴HM-1∶IMSS株滋养体37℃孵育,在孵育即刻、5min、10min加入红细胞,检测滋养体吞噬红细胞的能力,并以正常小鼠血清和抗克氏锥虫抗体TCE04作为对照。结果,经单克隆抗体3F7孵育即刻的HM-1∶IMSS虫株滋养体吞噬红细胞能力明显减弱(P<0.001),而4G6抑制滋养体吞噬红细胞的作用不如前者明显。提示,抗细胞膜单克隆抗体对抑制滋养体吞噬红细胞有显著作用,但随着时间的推移,抑制作用明显减弱。 相似文献
9.
Yoshihiro Katagiri Kazuhide Mabuchi Tadanori Itakura Kohji Naora Kikuo Iwamoto Yoshimasa Nozu Shun-ichi Hirai Nobumasa Ikeda Toshio Kawai 《Cancer chemotherapy and pharmacology》1989,24(4):238-242
Summary Physicochemical properties of two types of adriamycin preparation, suspensions and emulsions prepared for i.a. chemotherapy of hepatocellular cacinoma, were investigated. A suspension was prepared by dispersing adriamycin directly into the lipid contrast medium, Lipiodol, whereas an emulsion was obtained by emulsifying an aqueous solution of adriamycin into Lipiodol. The dispersibility of the drug in each preparation was examined microscopically. The chemical stability of and drug release from the preparation were determined by high-performance liquid chromatography and spectrophotometry, respectively. The suspension was then given to ten patients with primary hepatocellular carcinoma. The suspension maintained good dispersibility without coagulation of drug particles, whereas coalescence of aqueous droplets and the resultant phase separation occurred 4 h after preparation of the emulsion. Both preparations maintained the initial drug content for at least 1 week at room temperature. The release of adriamycin was more prolonged in the suspension than in the emulsion. After i.a. administration of the suspension, a selective accumulation of Lipiodol in the tumor and decrease in serum -fetoprotein (AFP) levels were found in most patients. A significant amount of adriamycin was still detected in hepatic speciments resected from two patients 1 and 2 months after treatment. These findings suggest that the adriamycin-Lipiodol suspension may be a useful preparation for targeting chemotherapy to hepatocellular carcinoma. 相似文献
10.