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Kevin L Taylor Rhonda K Oates Ron Grane Douglas W Leaman Ernest C Borden Daniel J Lindner 《Journal of interferon & cytokine research》2006,26(5):353-361
Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma. To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo. SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively. IFN-alpha1,8, which is active against murine and human cells, inhibited SVR and MS1-VEGF proliferation in vitro by 40% at 10(3) U/mL (p = 0.028). In vivo, IFN-alpha1,8 inhibited SVR tumor volume by 71% (p = 0.047) and MS1-VEGF volume by 79% (p = 0.003). Tumor-induced angiogenesis was decreased in SVR tumors by 52% (p = 0.005) and in MS1-VEGF tumors by 58% (p = 0.001). Sera from IFN-alpha1,8-treated mice bearing either SVR or MS1-VEGF tumors demonstrated a 5-fold increase in IP-10/CXCL10 (p = 0.001), an IFN-induced antiangiogenic protein. Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001). An IP-10 blocking antibody restored vessel formation to 80% of untreated controls (p = 0.001). Given the magnitude of the in vivo response, these data suggested that the antitumor effects of IFN-alpha1,8 were likely mediated through angiogenesis inhibition rather than solely by direct inhibition of tumor cell proliferation. 相似文献
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Salivary disease in childhood is uncommon. Clinical features are much the same as in adult disease, however, congenital, inflammation, and functional disease is more common. Management is governed by the same general principles in all age groups. Congenital abnormalities are rare. Inflammation, either bacterial or viral, is the most common disease. Chronic sialadenitis usually resolves at puberty. Neoplasia is rare, and the majority of tumors are benign and occur in the parotid gland. Malignancy is suggested by rapid growth, pain, skin fixation, and lymphadenopathy. Surgical treatment of sialorrhea should only be considered after careful assessment. Relocation of the submandibular ducts is the treatment of choice. 相似文献
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The cases of 46 children who had been abused sexually an average of 2.6 years previously, were reviewed and the non-offending parents were interviewed with emphasis on how they viewed the professional persons who had seen their children, and their opinions of the legal processes that were instituted. The parents found most professional groups helpful, with officers from the Department of Youth and Community Services being seen as the least helpful. Twenty-one of the cases went to court; in 12 cases this resulted in a conviction, and prison sentences were imposed on six of the offenders. Children found the court experience distressing and most parents expressed dissatisfaction with the outcome of the court hearing. Children were more likely to be required to give evidence in court if the offender had legal representation. Persisting behavioural problems and poor school performance were more likely to occur in those cases in which there had been court hearings. A review of Police Department records of children who had attended the hospital for the management of sexual assault, showed that 10 of the 107 children who are now aged over 14 years, have themselves been convicted of violent crimes since their episode of sexual assault. Long-term intervention is required to help many of these children, some legal reforms are necessary to reduce the stress that they experience when there is a court hearing, and all the professional groups that are likely to become involved with the problem of the sexual abuse of children need to be better informed about its seriousness and consequences. 相似文献
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Abstract: The baseline knowledge about skin cancer prevention of 983 children aged 8 to 12 years was assessed by a pretest questionnaire. After the pretest, half were given a formal presentation about skin cancer prevention. The other half participated in an informal, question–and–answer session, which covered all material from the formal presentation. Two weeks later, all students completed an identical post–test. The students had a high baseline level of knowledge about skin cancer prevention. Knowledge increased for most items in the post–test questionnaire. In all age groups there was no difference in results between the formal and interactive teaching sessions, except among eight–year–olds, for whom the formal presentation was more effective. As much solar skin damage occurs before adolescence, the younger age group is the important target for skin cancer prevention programs. (Aust N Z J Public Health 1997; 21: 602–5) 相似文献
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Does altered biomechanics cause marrow edema? 总被引:21,自引:0,他引:21
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Three hundred and forty-two health professionals who deal with children, including general practitioners, paediatric residents and paediatric nurses were asked questions about their knowledge of infant feeding, particularly how they would recommend mothers to reconstitute milk formulae. A proportion of errors was noted in all groups, with errors occurring more frequently in the medical groups. Mothers seeking feeding advice are most likely to obtain the correct answers from paediatrically trained nurses. 相似文献
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