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Rapid industrialization and urbanization has led to increasing input of chemical contaminants into the aquatic environment of Malaysia. Despite the threat civilization poses to the biota, there are still very few relevant studies on ecotoxicological testing of river ecosystems. To overcome this knowledge gap, we examined lethal and genotoxic effects of sediments from different rivers of the northern Malaysia against Chironomus kiiensis, a group well represented in the aquatic fauna of this region. We exposed the larvae to sediments from Selama River (SR), Permatang Rawa River (PRR) and Kilang Ubi River (KUR) at various durations (0, 6, 12, 24 and 48 h). The larval mortality was monitored, whereas DNA damage in survivors' cells was determined using the comet assay. Pollution level indexed by the amounts of heavy metals and other organic contaminants in the sediment showed progressive increases from SR to PRR to KUR. Highly polluted sediments (PRR to KUR) were detrimental to C. kiiensis larvae, most of which did not survive following exposure for long periods. DNA analyses revealed greater damages in nuclei derived from larvae maintained on polluted sediments, in particular, those from KUR. The effects on the genomic material of C. kiiensis larvae occurred in a time‐dependent manner, with damage level increasing as exposure time progressed. Our results highlight the genotoxic properties of polluted sediments. More importantly, this study showed that C. kiiensis larvae could respond to different levels of pollution with respect to exposure time. It is concluded that C. kiiensis larvae is a potential candidate for river ecotoxicological monitoring. Copyright © 2012 John Wiley & Sons, Ltd.  相似文献   
3.
We present an approach for mining frequent conjunctive in arbitrary relational databases. Our pattern class is the simple, but appealing subclass of simple conjunctive queries. Our algorithm, called Conqueror $^+$ , is capable of detecting previously unknown functional and inclusion dependencies that hold on the database relations as well as on joins of relations. These newly detected dependencies are then used to prune redundant queries. We propose an efficient database-oriented implementation of our algorithm using SQL and provide several promising experimental results.  相似文献   
4.
Many carboxylic molecules, ranging from drugs to flavors and fragrances, contain chiral centers. As a consequence, research has been carried out in order to design and synthesize artificial receptors for carboxylic anions. Many problems have to be solved for binding anions. The results obtained in the binding of carboxylic anions by guanidine, secondary ammonium and metal-center have been selected. The last part of this review focuses on chiral recognition of carboxylic anions by organic and metal-based chiral receptors.  相似文献   
5.
In this article, a new database that relates structural information from proteins in protein data bank to closely related protein sequences in humans was developed. Because the match criteria are extremely stringent, the structure of proteins in other species to infer characteristics of the human proteins was used. As a demonstration of the approach, this database has been applied to the problem of identifying likely trypsin miscleavage sites, a significant problem in proteomics. However, the approach is very general, and can be used to answer many kinds of structural questions (including questions related to posttranslational modifications). The study found that both the surface area and the secondary structure of cleavage sites have highly statistically significant effects on trypsin cleavage. The results of this analysis do not, however, suggest that surface area or secondary structure properties of particular peptides can be used to predict miscleavage sites, at least at a global level. This analysis of cleavage sites demonstrates the general power of homology-based techniques, in which the characteristics of a single protein that has a structure that has been solved can be used to infer properties of other proteins. We expect that our database of related proteins, structures, and sequences and our ability to query experimentally determined sets of peptides against this database will allow us to answer many other questions relation to global protein expression and modification.  相似文献   
6.
One hundred ASA I orthopaedic surgical patients (four randomized groups) were anaesthetized using continuous propofol and intermittent fentanyl (TIVA), with controlled ventilation via a tracheal tube in groups 1 and 2, and a laryngeal mask airway (LMA) in groups 3 and 4. Neuromuscular blockers were used in groups 1 and 3 only. There were no significant differences between groups in total anaesthetic requirements, as assessed by cardiovascular variables and movement. Coughing interfered with surgery and made controlled ventilation difficult to manage. In contrast, movement not associated with coughing did not impair surgery or ventilation. Patients in group 2 (tracheal tube, no neuromuscular blocker) required more interventions for coughing than the other groups, while patients in group 4 (LMA, no neuromuscular blocker) needed more boluses for movement than groups 1 and 3. Groups 1 and 2 (tracheal tube) had significantly higher heart rates and mean arterial pressures than groups 3 and 4 for varying periods up to 5 min after insertion of the airway management device. There was no correlation between mean arterial pressure and plasma concentrations of catecholamines related to insertion of either the tracheal tube or LMA. The LMA was found to be a highly effective device for controlled ventilation in TIVA and easier to manage than the tracheal tube in the absence of neuromuscular blockers.  相似文献   
7.
We study, by means of numerical simulation, the impact of doping and traps on the performance of the “solar blind” ultraviolet Schottky detector based on AlGaN. We implemented physical models and AlGaN material properties taken from the literature, or from the interpolation between the binary materials (GaN and AlN) weighted by the mole fractions. We found that doping and traps highly impact the spectral response of the device, and in particular a compromise in the doping concentration must be reached in order to optimize the spectral response of the detector. These results give us a powerful tool to quantitatively understand the impact of elaboration and processing conditions on photodetector characteristics, and thus identify the key issues for the development of the technology.  相似文献   
8.
Given the accelerated growth in tablet devices, smartphones, and netbooks, designers are faced with serious challenges to meet the needs of mobility in terms of battery life and form factor. It is vital to investigate how to deliver the best mobile experience to users while ensuring adequate levels of performance. In this paper, we present a power management evaluation of multi-core processor systems by comparing thermal power, battery life, and performance when running different types of workloads under a limited number of cores. To show the potential gains from a system power management perspective, we have assessed a mobile platform featuring the Second Generation Intel Core i5 processor, and tested it on a wide selection of workloads and benchmarks. Experimental results show significant thermal power reduction (up to 40 %) in a variety of scenarios, while system performance was sustained in most cases but sacrificed in a few other uncommon situations.  相似文献   
9.
Background: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease that urgently needs effective therapy. Rosavin, a major constituent of the Rhodiola Rosea plant of the family Crassulaceae, is believed to exhibit multiple pharmacological effects on diverse diseases. However, its effect on non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, and the underlying mechanisms are not fully illustrated. Aim: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA-6881-5P and lnc-SPARCL1-1:2) in NASH rats. Results: High sucrose high fat (HSHF) diet-induced NASH rats were treated with different concentrations of rosavin (10, 20, and 30 mg/kg/day) for the last four weeks of dietary manipulation. The data revealed that rosavin had the ability to modulate the expression of the hepatic cell death-related RNA panel through the upregulation of both (HSPD1/TNF/MMP14/ITGB1) mRNAs and their epigenetic regulators (miRNA-6881-5P and lnc-SPARCL1-1:2). Moreover, rosavin ameliorated the deterioration in both liver functions and lipid profile, and thereby improved the hepatic inflammation, fibrosis, and apoptosis, as evidenced by the decreased protein levels of IL6, TNF-α, and caspase-3 in liver sections of treated animals compared to the untreated NASH rats. Conclusion: Rosavin has demonstrated a potential ability to attenuate disease progression and inhibit hepatic cell death in the NASH animal model. The produced effect was correlated with upregulation of the hepatic cell death-related (HSPD1, TNF, MMP14, and ITGB1) mRNAs—(miRNA-6881-5P—(lnc-SPARCL1-1:2) RNA panel.  相似文献   
10.
Hybrid organic–inorganic all thin film photovoltaic junctions PMeT(Y)/CdS(X) were investigated, where PMeT(Y) is the conducting polymer poly(3-methylthiophene) doped with various anions Y=CF3SO3, ClO4, BF4, PF6, and CdS(X) cadmium sulfide doped with various elements X=Cu, Ni, Al, As and Sb. CdS(X) films were spray deposited on conducting and transparent indium-tin oxide (ITO) glass, and PMeT(Y) films were electrodeposited onto the CdS(X) film to form the junction. The electrochemical investigation of the mechanism of electrodeposition and growth of the PMeT(Y) films by means of chronoamperometry, and of the charge transfer behavior of the PMeT(Y)/CdS(X) junctions by means of cyclic voltammetry revealed a strong effect of the nature of Y and X. The same strong effect of Y was also found with PMeT(Y)/ITO junctions, and may have some generality. It was showed that the best quality of contact between the organic and inorganic phases, from an electrochemical viewpoint and in solution, was obtained with the junction, pointing towards a similarly better photovoltaic performance in solid state. This was indeed the case, and it was found that higher short-circuit current, open-circuit photovoltage and energy conversion efficiency, approaching 4%, could be obtained with this junction.  相似文献   
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